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FBXW11 F-box and WD repeat domain containing 11 [ Homo sapiens (human) ]

Gene ID: 23291, updated on 20-Dec-2019

Summary

Official Symbol
FBXW11provided by HGNC
Official Full Name
F-box and WD repeat domain containing 11provided by HGNC
Primary source
HGNC:HGNC:13607
See related
Ensembl:ENSG00000072803 MIM:605651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See FBXW11 in Genome Data Viewer
Location:
5q35.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (171861549..172009604, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (171288553..171433877, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377725 Neighboring gene uncharacterized LOC107986476 Neighboring gene Sharpr-MPRA regulatory region 1765 Neighboring gene serine/threonine kinase 10 Neighboring gene uncharacterized LOC107986477 Neighboring gene EF-hand calcium binding domain 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2011-12-07)

ClinGen Genome Curation Page
Triplosensitivity

Little evidence for dosage pathogenicity (Last evaluated (2011-12-07)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of F-box and WD repeat domain containing 11 (FBXW11) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with F-box and WD-40 domain protein 11 (FBXW11; FBW1B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
vpu Co-expression of HIV-1 Vpu with beta-TrCP2 induces degradation of total cellular CD4 content; Vpu-mediated CD4 down-modulation is inhibited by double silencing of beta-TrCP1 and beta-TrCP2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box and WD repeats protein beta-TrCP2
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 1B
F-box protein Fbw1b
F-box/WD repeat-containing protein 1B
beta-transducin repeat-containing protein 2
homologous to Slimb protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009275.2 RefSeqGene

    Range
    5001..150322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012300.2NP_036432.2  F-box/WD repeat-containing protein 11 isoform C

    See identical proteins and their annotated locations for NP_036432.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (C).
    Source sequence(s)
    AB014596, AF176022, BC026213
    Consensus CDS
    CCDS34289.1
    UniProtKB/Swiss-Prot
    Q9UKB1
    Related
    ENSP00000265094.5, ENST00000265094.9
    Conserved Domains (4) summary
    cd00200
    Location:240518
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:243278
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:78116
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:120167
    F-box-like
  2. NM_033644.2NP_387448.2  F-box/WD repeat-containing protein 11 isoform B

    See identical proteins and their annotated locations for NP_387448.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. This variant encodes a shorter isoform (B), compared to isoform C.
    Source sequence(s)
    AB014596, BC026213
    Consensus CDS
    CCDS47341.1
    UniProtKB/Swiss-Prot
    Q9UKB1
    Related
    ENSP00000296933.6, ENST00000296933.10
    Conserved Domains (4) summary
    cd00200
    Location:227505
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230265
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:65103
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:107154
    F-box-like
  3. NM_033645.2NP_387449.2  F-box/WD repeat-containing protein 11 isoform A

    See identical proteins and their annotated locations for NP_387449.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the 5' coding region, compared to variant 3, and encodes a shorter isoform (A), compared to isoform C.
    Source sequence(s)
    AB014596, BC026213
    Consensus CDS
    CCDS47340.1
    UniProtKB/Swiss-Prot
    Q9UKB1
    Related
    ENSP00000377391.2, ENST00000393802.6
    Conserved Domains (4) summary
    cd00200
    Location:206484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:209244
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4482
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:86133
    F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    171861549..172009604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265855.5XP_005265912.1  F-box/WD repeat-containing protein 11 isoform X1

    See identical proteins and their annotated locations for XP_005265912.1

    Conserved Domains (4) summary
    cd00200
    Location:261539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:264299
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:99137
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:141188
    F-box-like
  2. XM_005265858.3XP_005265915.1  F-box/WD repeat-containing protein 11 isoform X5

    See identical proteins and their annotated locations for XP_005265915.1

    UniProtKB/TrEMBL
    B4DH70
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  3. XM_005265856.2XP_005265913.1  F-box/WD repeat-containing protein 11 isoform X3

    See identical proteins and their annotated locations for XP_005265913.1

    Conserved Domains (4) summary
    cd00200
    Location:229507
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232267
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:67105
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:109156
    F-box-like
  4. XM_017009281.2XP_016864770.1  F-box/WD repeat-containing protein 11 isoform X6

    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like; F-box-like
  5. XM_017009280.2XP_016864769.1  F-box/WD repeat-containing protein 11 isoform X5

    UniProtKB/TrEMBL
    B4DH70
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  6. XM_017009279.1XP_016864768.1  F-box/WD repeat-containing protein 11 isoform X2

  7. XM_005265857.2XP_005265914.1  F-box/WD repeat-containing protein 11 isoform X4

    See identical proteins and their annotated locations for XP_005265914.1

    Conserved Domains (4) summary
    cd00200
    Location:213491
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:216251
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:5189
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:93140
    F-box-like; F-box-like
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