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FBXW11 F-box and WD repeat domain containing 11 [ Homo sapiens (human) ]

Gene ID: 23291, updated on 6-May-2021

Summary

Official Symbol
FBXW11provided by HGNC
Official Full Name
F-box and WD repeat domain containing 11provided by HGNC
Primary source
HGNC:HGNC:13607
See related
Ensembl:ENSG00000072803 MIM:605651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

See FBXW11 in Genome Data Viewer
Location:
5q35.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (171861549..172006638, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (171288553..171433642, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377725 Neighboring gene uncharacterized LOC107986476 Neighboring gene Sharpr-MPRA regulatory region 1765 Neighboring gene serine/threonine kinase 10 Neighboring gene uncharacterized LOC107986477 Neighboring gene EF-hand calcium binding domain 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available
Neurodevelopmental, jaw, eye, and digital syndrome
MedGen: C5394477 OMIM: 618914 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2011-12-07)

ClinGen Genome Curation Page
Triplosensitivity

Little evidence for dosage pathogenicity (Last evaluated 2011-12-07)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of F-box and WD repeat domain containing 11 (FBXW11) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with F-box and WD-40 domain protein 11 (FBXW11; FBW1B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
vpu Co-expression of HIV-1 Vpu with beta-TrCP2 induces degradation of total cellular CD4 content; Vpu-mediated CD4 down-modulation is inhibited by double silencing of beta-TrCP1 and beta-TrCP2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
involved_in NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in post-translational protein modification TAS
Traceable Author Statement
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination TAS
Traceable Author Statement
more info
 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box and WD repeats protein beta-TrCP2
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 1B
F-box protein Fbw1b
F-box/WD repeat-containing protein 1B
beta-transducin repeat-containing protein 2
homologous to Slimb protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009275.2 RefSeqGene

    Range
    5001..150322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001378974.1NP_001365903.1  F-box/WD repeat-containing protein 11 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Related
    ENSP00000428753.2, ENST00000517395.6
    Conserved Domains (4) summary
    cd00200
    Location:261539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:264299
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:99137
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:141188
    F-box-like
  2. NM_001378975.1NP_001365904.1  F-box/WD repeat-containing protein 11 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Conserved Domains (4) summary
    cd00200
    Location:238516
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:241276
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:78116
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:120165
    F-box-like
  3. NM_001378976.1NP_001365905.1  F-box/WD repeat-containing protein 11 isoform F

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Conserved Domains (4) summary
    cd00200
    Location:229507
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232267
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:67105
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:109156
    F-box-like
  4. NM_001378977.1NP_001365906.1  F-box/WD repeat-containing protein 11 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  5. NM_001378978.1NP_001365907.1  F-box/WD repeat-containing protein 11 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  6. NM_001378979.1NP_001365908.1  F-box/WD repeat-containing protein 11 isoform H

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  7. NM_001378980.1NP_001365909.1  F-box/WD repeat-containing protein 11 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Conserved Domains (4) summary
    cd00200
    Location:206484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:209244
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4482
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:86133
    F-box-like
  8. NM_012300.3NP_036432.2  F-box/WD repeat-containing protein 11 isoform C

    See identical proteins and their annotated locations for NP_036432.2

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Consensus CDS
    CCDS34289.1
    UniProtKB/Swiss-Prot
    Q9UKB1
    Related
    ENSP00000265094.5, ENST00000265094.9
    Conserved Domains (4) summary
    cd00200
    Location:240518
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:243278
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:78116
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:120167
    F-box-like
  9. NM_033644.3NP_387448.2  F-box/WD repeat-containing protein 11 isoform B

    See identical proteins and their annotated locations for NP_387448.2

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Consensus CDS
    CCDS47341.1
    UniProtKB/Swiss-Prot
    Q9UKB1
    Related
    ENSP00000296933.6, ENST00000296933.10
    Conserved Domains (4) summary
    cd00200
    Location:227505
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230265
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:65103
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:107154
    F-box-like
  10. NM_033645.3NP_387449.2  F-box/WD repeat-containing protein 11 isoform A

    See identical proteins and their annotated locations for NP_387449.2

    Status: REVIEWED

    Source sequence(s)
    AC011387, AC011410, AC113342
    Consensus CDS
    CCDS47340.1
    UniProtKB/Swiss-Prot
    Q9UKB1
    Related
    ENSP00000377391.2, ENST00000393802.6
    Conserved Domains (4) summary
    cd00200
    Location:206484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:209244
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4482
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:86133
    F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    171861549..172006638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009279.1XP_016864768.1  F-box/WD repeat-containing protein 11 isoform X2

  2. XM_005265857.2XP_005265914.1  F-box/WD repeat-containing protein 11 isoform X4

    See identical proteins and their annotated locations for XP_005265914.1

    Conserved Domains (4) summary
    cd00200
    Location:213491
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:216251
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:5189
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:93140
    F-box-like
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