Format

Send to:

Choose Destination

Fbxw11 F-box and WD-40 domain protein 11 [ Mus musculus (house mouse) ]

Gene ID: 103583, updated on 27-Aug-2019

Summary

Official Symbol
Fbxw11provided by MGI
Official Full Name
F-box and WD-40 domain protein 11provided by MGI
Primary source
MGI:MGI:2144023
See related
Ensembl:ENSMUSG00000020271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOS; BTRC2; BTRCP2; Fbxw1b; AA536858; 2310065A07Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 24.5), whole brain E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs

Genomic context

See Fbxw11 in Genome Data Viewer
Location:
11; 11 A4
Exon count:
15
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32642555..32746816)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (32542875..32646816)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 9 Neighboring gene serine/threonine kinase 10 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35723 Neighboring gene small integral membrane protein 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box and WD repeats protein beta-TrCP2
F-box and WD-40 domain protein 1B
F-box/WD repeat-containing protein 1B
homologous to Slimb protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271347.1NP_001258276.1  F-box/WD repeat-containing protein 11 isoform b

    See identical proteins and their annotated locations for NP_001258276.1

    Status: VALIDATED

    Source sequence(s)
    AK149139, AL669951, CA326854
    Consensus CDS
    CCDS70157.1
    UniProtKB/Swiss-Prot
    Q5SRY7
    Related
    ENSMUSP00000090893.6, ENSMUST00000093205.12
    Conserved Domains (5) summary
    COG2319
    Location:227527
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:240518
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12125
    Location:78116
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:120167
    F-box-like; F-box-like
    sd00039
    Location:243278
    7WD40; WD40 repeat [structural motif]
  2. NM_001271348.1NP_001258277.1  F-box/WD repeat-containing protein 11 isoform c

    See identical proteins and their annotated locations for NP_001258277.1

    Status: VALIDATED

    Source sequence(s)
    AK041532, AL669951, CA326854
    Consensus CDS
    CCDS70158.1
    UniProtKB/Swiss-Prot
    Q5SRY7
    Related
    ENSMUSP00000104991.1, ENSMUST00000109366.7
    Conserved Domains (4) summary
    cd00200
    Location:227505
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230265
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:65103
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:107154
    F-box-like
  3. NM_001271349.1NP_001258278.1  F-box/WD repeat-containing protein 11 isoform d

    See identical proteins and their annotated locations for NP_001258278.1

    Status: VALIDATED

    Source sequence(s)
    AK168667, AL669951, CA326854
    UniProtKB/Swiss-Prot
    Q5SRY7
    Conserved Domains (4) summary
    cd00200
    Location:206484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:209244
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4482
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:86133
    F-box-like
  4. NM_001363353.1NP_001350282.1  F-box/WD repeat-containing protein 11 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like; F-box-like
  5. NM_001363354.1NP_001350283.1  F-box/WD repeat-containing protein 11 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  6. NM_001363355.1NP_001350284.1  F-box/WD repeat-containing protein 11 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    Conserved Domains (4) summary
    cd00200
    Location:142420
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:145180
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:2269
    F-box-like
    cl26390
    Location:118
    Beta-TrCP_D; D domain of beta-TrCP
  7. NM_134015.3NP_598776.1  F-box/WD repeat-containing protein 11 isoform a

    See identical proteins and their annotated locations for NP_598776.1

    Status: VALIDATED

    Source sequence(s)
    AK041532, AL669951, CB526764
    Consensus CDS
    CCDS36125.1
    UniProtKB/Swiss-Prot
    Q5SRY7
    Related
    ENSMUSP00000075721.7, ENSMUST00000076383.7
    Conserved Domains (5) summary
    COG2319
    Location:248548
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:261539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12125
    Location:99137
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:141188
    F-box-like; F-box-like
    sd00039
    Location:264299
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    32642555..32746816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514433.3XP_006514496.1  F-box/WD repeat-containing protein 11 isoform X1

    Conserved Domains (5) summary
    COG2319
    Location:216516
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:229507
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12125
    Location:67105
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:109156
    F-box-like; F-box-like
    sd00039
    Location:232267
    7WD40; WD40 repeat [structural motif]
Support Center