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Fbxw11 F-box and WD-40 domain protein 11 [ Mus musculus (house mouse) ]

Gene ID: 103583, updated on 8-Feb-2024

Summary

Official Symbol
Fbxw11provided by MGI
Official Full Name
F-box and WD-40 domain protein 11provided by MGI
Primary source
MGI:MGI:2144023
See related
Ensembl:ENSMUSG00000020271 AllianceGenome:MGI:2144023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOS; BTRC2; BTRCP2; Fbxw1b; 2310065A07Rik
Summary
Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein ligase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of NIK/NF-kappaB signaling; and positive regulation of circadian rhythm. Located in cytosol and nucleus. Part of SCF ubiquitin ligase complex. Is expressed in cap mesenchyme; early tubule; ovary; and testis. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 24.5), whole brain E14.5 (RPKM 24.2) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxw11 in Genome Data Viewer
Location:
11 A4; 11 19.02 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32592595..32696816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32642555..32746816)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32442680-32442833 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene serine/threonine kinase 10 Neighboring gene STARR-positive B cell enhancer ABC_E5214 Neighboring gene STARR-seq mESC enhancer starr_29115 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35723 Neighboring gene small integral membrane protein 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
F-box/WD repeat-containing protein 11
Names
F-box and WD repeats protein beta-TrCP2
F-box and WD-40 domain protein 1B
F-box/WD repeat-containing protein 1B
homologous to Slimb protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271347.2NP_001258276.1  F-box/WD repeat-containing protein 11 isoform b

    See identical proteins and their annotated locations for NP_001258276.1

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    Consensus CDS
    CCDS70157.1
    UniProtKB/Swiss-Prot
    Q3TGM9, Q3TLZ8, Q5SRY7, Q8BY90, Q8K022, Q923H0
    UniProtKB/TrEMBL
    Q8CHD5
    Related
    ENSMUSP00000090893.7, ENSMUST00000093205.13
    Conserved Domains (4) summary
    cd00200
    Location:240518
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:243278
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:78116
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:120167
    F-box-like
  2. NM_001271348.2NP_001258277.1  F-box/WD repeat-containing protein 11 isoform c

    See identical proteins and their annotated locations for NP_001258277.1

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    Consensus CDS
    CCDS70158.1
    UniProtKB/TrEMBL
    Q8CHD5
    Related
    ENSMUSP00000104991.2, ENSMUST00000109366.8
    Conserved Domains (4) summary
    cd00200
    Location:227505
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:230265
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:65103
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:107154
    F-box-like
  3. NM_001271349.2NP_001258278.1  F-box/WD repeat-containing protein 11 isoform d

    See identical proteins and their annotated locations for NP_001258278.1

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    UniProtKB/TrEMBL
    Q8CHD5
    Conserved Domains (4) summary
    cd00200
    Location:206484
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:209244
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4482
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:86133
    F-box-like
  4. NM_001363353.2NP_001350282.1  F-box/WD repeat-containing protein 11 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    UniProtKB/TrEMBL
    Q8CHD5
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  5. NM_001363354.2NP_001350283.1  F-box/WD repeat-containing protein 11 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    UniProtKB/TrEMBL
    Q8CHD5
    Conserved Domains (4) summary
    cd00200
    Location:208486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:211246
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:4684
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:88135
    F-box-like
  6. NM_001363355.2NP_001350284.1  F-box/WD repeat-containing protein 11 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    UniProtKB/TrEMBL
    Q8CHD5
    Conserved Domains (4) summary
    cd00200
    Location:142420
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:145180
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:2269
    F-box-like
    cl26390
    Location:118
    Beta-TrCP_D; D domain of beta-TrCP
  7. NM_134015.4NP_598776.1  F-box/WD repeat-containing protein 11 isoform a

    See identical proteins and their annotated locations for NP_598776.1

    Status: VALIDATED

    Source sequence(s)
    AL669844, AL669951
    Consensus CDS
    CCDS36125.1
    UniProtKB/TrEMBL
    Q8CHD5
    Related
    ENSMUSP00000075721.8, ENSMUST00000076383.8
    Conserved Domains (4) summary
    cd00200
    Location:261539
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:264299
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:99137
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:141188
    F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32592595..32696816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514433.4XP_006514496.1  F-box/WD repeat-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    Q8CHD5
    Conserved Domains (4) summary
    cd00200
    Location:229507
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:232267
    7WD40; WD40 repeat [structural motif]
    pfam12125
    Location:67105
    Beta-TrCP_D; D domain of beta-TrCP
    pfam12937
    Location:109156
    F-box-like