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Zbtb40 zinc finger and BTB domain containing 40 [ Mus musculus (house mouse) ]

Gene ID: 230848, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb40provided by MGI
Official Full Name
zinc finger and BTB domain containing 40provided by MGI
Primary source
MGI:MGI:2682254
See related
Ensembl:ENSMUSG00000060862 AllianceGenome:MGI:2682254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm571; mKIAA0478; C230087D24
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in DNA damage response and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZBTB40 (zinc finger and BTB domain containing 40). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 3.9), ovary adult (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb40 in Genome Data Viewer
Location:
4 D3; 4 69.05 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136707043..136776129, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136979732..137048820, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11774 Neighboring gene complement component 1, q subcomponent, alpha polypeptide Neighboring gene Eph receptor A8 Neighboring gene predicted gene, 23834 Neighboring gene STARR-seq mESC enhancer starr_11775 Neighboring gene predicted gene, 31648 Neighboring gene predicted gene 13001

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Long noncoding RNA ZBTB40-IT1 regulates bone mass by directing the differentiation of human bone marrow mesenchymal stromal cells via the microRNA-514a-3p/FOXO4 axis. Shi Z, et al. Hum Cell, 2022 Sep. PMID 35676609
  2. Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility. Cui Y, et al. Cells, 2023 Apr 26. PMID 37174664, Free PMC Article
  3. Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass. Doolittle ML, et al. PLoS Genet, 2020 Jun. PMID 32497039, Free PMC Article
  4. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  5. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility.
    Title: Zbtb40 Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility.
  2. Long noncoding RNA ZBTB40-IT1 regulates bone mass by directing the differentiation of human bone marrow mesenchymal stromal cells via the microRNA-514a-3p/FOXO4 axis.
    Title: Long noncoding RNA ZBTB40-IT1 regulates bone mass by directing the differentiation of human bone marrow mesenchymal stromal cells via the microRNA-514a-3p/FOXO4 axis.
  3. Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.
    Title: Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC62412

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198248.1 → NP_937891.1  zinc finger and BTB domain-containing protein 40

    See identical proteins and their annotated locations for NP_937891.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059177
    Consensus CDS
    CCDS18814.1
    UniProtKB/TrEMBL
    Q571D3, Q6PCS8
    Related
    ENSMUSP00000061899.8, ENSMUST00000049583.8
    Conserved Domains (7) summary
    smart00225
    Location:25 → 113
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:872 → 1078
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:856 → 876
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:971 → 989
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:997 → 1019
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:19 → 113
    BTB; BTB/POZ domain
    pfam13465
    Location:925 → 950
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136707043..136776129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538763.5 → XP_006538826.1  zinc finger and BTB domain-containing protein 40 isoform X1

    UniProtKB/TrEMBL
    Q571D3
    Conserved Domains (4) summary
    COG5048
    Location:872 → 1077
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:856 → 876
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:970 → 988
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)

  2. XM_006538764.5 → XP_006538827.1  zinc finger and BTB domain-containing protein 40 isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:827 → 848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:854 → 876
    zf-C2H2; Zinc finger, C2H2 type
    cd18225
    Location:1 → 116
    BTB_POZ_ZBTB40; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40)
    pfam13465
    Location:869 → 893
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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