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GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 [ Homo sapiens (human) ]

Gene ID: 23062, updated on 6-Sep-2022


Official Symbol
GGA2provided by HGNC
Official Full Name
golgi associated, gamma adaptin ear containing, ARF binding protein 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000103365 MIM:606005; AllianceGenome:HGNC:16064
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]
Ubiquitous expression in lymph node (RPKM 28.0), thyroid (RPKM 15.2) and 25 other tissues See more
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Genomic context

See GGA2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (23463542..23524359, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23739620..23786600, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23474863..23521815, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 7 Neighboring gene RN7SK pseudogene 23 Neighboring gene uncharacterized LOC124903667 Neighboring gene cyclin Y like 7 (pseudogene) Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene Sharpr-MPRA regulatory region 1793 Neighboring gene SUB1 pseudogene 4

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies GGA2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
Pr55(Gag) gag siRNA-mediated depletion of GGA2 leads to a significant increase in particle release in an HIV-1 Gag late domain-dependent manner, while GGA2 overexpression severely reduces virus particle production by impairing Gag trafficking to the membrane PubMed
Vpr vpr Expression of a patient-derived HIV-1 Vpr protein reveals a significant reduction in Vpr nuclear import. Vpr F72L mutation is responsible for this decreased Vpr nuclear import and the F72L mutant is co-localized with gamma-adaptin in the Golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ20966, KIAA1080

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
enables small GTPase binding IDA
Inferred from Direct Assay
more info
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
located_in early endosome membrane TAS
Traceable Author Statement
more info
located_in endosome membrane TAS
Traceable Author Statement
more info
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
ADP-ribosylation factor-binding protein GGA2
VHS domain and ear domain of gamma-adaptin
VHS domain and ear domain-containing protein
gamma-adaptin-related protein 2
golgi-localized, gamma ear-containing, ARF-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015044.4NP_055859.1  ADP-ribosylation factor-binding protein GGA2

    See identical proteins and their annotated locations for NP_055859.1

    Status: REVIEWED

    Source sequence(s)
    AC008915, AF165531, DA439738
    Consensus CDS
    Q9UJY4, Q9UPS2
    ENSP00000311962.4, ENST00000309859.8
    Conserved Domains (4) summary
    Alpha_adaptinC2; Adaptin C-terminal domain
    VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    23463542..23524359 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433801.1XP_047289757.1  ADP-ribosylation factor-binding protein GGA2 isoform X1

  2. XM_047433802.1XP_047289758.1  ADP-ribosylation factor-binding protein GGA2 isoform X2

Alternate T2T-CHM13v2.0


  1. NC_060940.1 Alternate T2T-CHM13v2.0

    23739620..23786600 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138640.1: Suppressed sequence

    NM_138640.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.