Format

Send to:

Choose Destination

NCOA6 nuclear receptor coactivator 6 [ Homo sapiens (human) ]

Gene ID: 23054, updated on 4-Nov-2018

Summary

Official Symbol
NCOA6provided by HGNC
Official Full Name
nuclear receptor coactivator 6provided by HGNC
Primary source
HGNC:HGNC:15936
See related
Ensembl:ENSG00000198646 MIM:605299; Vega:OTTHUMG00000032311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRC; AIB3; ASC2; PRIP; TRBP; RAP250
Summary
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in testis (RPKM 8.8), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See NCOA6 in Genome Data Viewer
Location:
20q11.22
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (34714774..34825649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33302578..33413433, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372599 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene gamma-glutamyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor coactivator 6 (NCOA6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding TAS
Traceable Author Statement
more info
PubMed 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor transcription coactivator activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoid X receptor binding TAS
Traceable Author Statement
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA recombination NAS
Non-traceable Author Statement
more info
PubMed 
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
DNA-templated transcription, initiation IDA
Inferred from Direct Assay
more info
PubMed 
brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular estrogen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
response to hormone TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 6
Names
NRC RAP250
PPAR-interacting protein
activating signal cointegrator-2
amplified in breast cancer protein 3
amplified in breast cancer-3 protein
cancer-amplified transcriptional coactivator ASC-2
nuclear receptor coactivator RAP250
nuclear receptor-activating protein, 250 kDa
peroxisome proliferator-activated receptor interacting protein
thyroid hormone receptor binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242539.2NP_001229468.1  nuclear receptor coactivator 6 isoform 2

    See identical proteins and their annotated locations for NP_001229468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as NCOA6-beta) is shorter than isoform 1.
    Source sequence(s)
    AF208227, AI498955, AL109824, BC069829, JF707637
    Consensus CDS
    CCDS74720.1
    UniProtKB/Swiss-Prot
    Q14686
    UniProtKB/TrEMBL
    F6M2K2
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  2. NM_001318240.1NP_001305169.1  nuclear receptor coactivator 6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1, also known as NCOA6-alpha). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AF208227, AL049709, AL109824
    Consensus CDS
    CCDS13241.1
    UniProtKB/Swiss-Prot
    Q14686
    Related
    ENSP00000363929.2, OTTHUMP00000030705, ENST00000374796.6, OTTHUMT00000078811
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  3. NM_014071.4NP_054790.2  nuclear receptor coactivator 6 isoform 1

    See identical proteins and their annotated locations for NP_054790.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1, also known as NCOA6-alpha).
    Source sequence(s)
    AI498955, AL109824, BC069829, CR749037
    Consensus CDS
    CCDS13241.1
    UniProtKB/Swiss-Prot
    Q14686
    Related
    ENSP00000351894.2, OTTHUMP00000030706, ENST00000359003.6, OTTHUMT00000078812
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    34714774..34825649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027750.2XP_016883239.1  nuclear receptor coactivator 6 isoform X15

  2. XM_017027743.2XP_016883232.1  nuclear receptor coactivator 6 isoform X5

  3. XM_017027751.1XP_016883240.1  nuclear receptor coactivator 6 isoform X16

    UniProtKB/TrEMBL
    F6M2K2
    Related
    ENSP00000481177.1, ENST00000612493.4
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  4. XM_017027739.1XP_016883228.1  nuclear receptor coactivator 6 isoform X1

  5. XM_017027740.2XP_016883229.1  nuclear receptor coactivator 6 isoform X1

  6. XM_017027745.2XP_016883234.1  nuclear receptor coactivator 6 isoform X9

  7. XM_017027742.2XP_016883231.1  nuclear receptor coactivator 6 isoform X3

  8. XM_011528727.3XP_011527029.1  nuclear receptor coactivator 6 isoform X7

    Conserved Domains (2) summary
    pfam09606
    Location:427855
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48195
    Nucleic_acid_bd; Putative nucleic acid-binding region
  9. XM_011528726.3XP_011527028.1  nuclear receptor coactivator 6 isoform X6

    Conserved Domains (2) summary
    pfam09606
    Location:427856
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48195
    Nucleic_acid_bd; Putative nucleic acid-binding region
  10. XM_011528721.3XP_011527023.1  nuclear receptor coactivator 6 isoform X4

    See identical proteins and their annotated locations for XP_011527023.1

    Conserved Domains (2) summary
    pfam09606
    Location:427867
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48195
    Nucleic_acid_bd; Putative nucleic acid-binding region
  11. XM_017027744.2XP_016883233.1  nuclear receptor coactivator 6 isoform X8

  12. XM_017027747.2XP_016883236.1  nuclear receptor coactivator 6 isoform X12

  13. XM_017027741.1XP_016883230.1  nuclear receptor coactivator 6 isoform X2

  14. XM_017027748.1XP_016883237.1  nuclear receptor coactivator 6 isoform X13

  15. XM_017027749.1XP_016883238.1  nuclear receptor coactivator 6 isoform X14

  16. XM_017027746.1XP_016883235.1  nuclear receptor coactivator 6 isoform X10

  17. XM_006723755.3XP_006723818.1  nuclear receptor coactivator 6 isoform X11

    See identical proteins and their annotated locations for XP_006723818.1

    UniProtKB/TrEMBL
    F6M2K3
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region

RNA

  1. XR_001754215.2 RNA Sequence

  2. XR_001754214.2 RNA Sequence

Support Center