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NCOA6 nuclear receptor coactivator 6 [ Homo sapiens (human) ]

Gene ID: 23054, updated on 10-Dec-2024

Summary

Official Symbol
NCOA6provided by HGNC
Official Full Name
nuclear receptor coactivator 6provided by HGNC
Primary source
HGNC:HGNC:15936
See related
Ensembl:ENSG00000198646 MIM:605299; AllianceGenome:HGNC:15936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRC; AIB3; ASC2; PRIP; TRBP; RAP250
Summary
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in testis (RPKM 8.8), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See NCOA6 in Genome Data Viewer
Location:
20q11.22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (34714774..34825651, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36435437..36546294, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33302578..33413454, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12843 Neighboring gene Sharpr-MPRA regulatory region 13945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12846 Neighboring gene tumor protein p53 inducible nuclear protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33384717-33385693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33385694-33386669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12848 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33450836-33451387 Neighboring gene gamma-glutamyltransferase 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12849

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear receptor coactivator 6 (NCOA6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0181

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear estrogen receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear retinoid X receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables nuclear thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 6
Names
NRC RAP250
PPAR-interacting protein
activating signal cointegrator-2
amplified in breast cancer protein 3
amplified in breast cancer-3 protein
cancer-amplified transcriptional coactivator ASC-2
nuclear receptor coactivator RAP250
nuclear receptor-activating protein, 250 kDa
peroxisome proliferator-activated receptor interacting protein
thyroid hormone receptor binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242539.2NP_001229468.1  nuclear receptor coactivator 6 isoform 2

    See identical proteins and their annotated locations for NP_001229468.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as NCOA6-beta) is shorter than isoform 1.
    Source sequence(s)
    AF208227, AI498955, AL109824, BC069829, JF707637
    Consensus CDS
    CCDS74720.1
    UniProtKB/TrEMBL
    F6M2K2, F6M2K4
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  2. NM_001318240.1NP_001305169.1  nuclear receptor coactivator 6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1, also known as NCOA6-alpha). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AF208227, AL049709, AL109824
    Consensus CDS
    CCDS13241.1
    UniProtKB/Swiss-Prot
    A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
    Related
    ENSP00000363929.2, ENST00000374796.6
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  3. NM_014071.5NP_054790.2  nuclear receptor coactivator 6 isoform 1

    See identical proteins and their annotated locations for NP_054790.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1, also known as NCOA6-alpha).
    Source sequence(s)
    AI498955, AL049709, AL109824, BC069829, CR749037
    Consensus CDS
    CCDS13241.1
    UniProtKB/Swiss-Prot
    A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
    Related
    ENSP00000351894.2, ENST00000359003.7
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    34714774..34825651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440068.1XP_047296024.1  nuclear receptor coactivator 6 isoform X33

    UniProtKB/TrEMBL
    F6M2K4
  2. XM_047440055.1XP_047296011.1  nuclear receptor coactivator 6 isoform X15

  3. XM_017027744.3XP_016883233.1  nuclear receptor coactivator 6 isoform X13

  4. XM_047440067.1XP_047296023.1  nuclear receptor coactivator 6 isoform X32

    UniProtKB/TrEMBL
    F6M2K4
  5. XM_047440059.1XP_047296015.1  nuclear receptor coactivator 6 isoform X19

  6. XM_047440054.1XP_047296010.1  nuclear receptor coactivator 6 isoform X14

  7. XM_047440052.1XP_047296008.1  nuclear receptor coactivator 6 isoform X12

  8. XM_047440064.1XP_047296020.1  nuclear receptor coactivator 6 isoform X29

    UniProtKB/TrEMBL
    F6M2K4
    Related
    ENSP00000481935.1, ENST00000616167.1
  9. XM_017027751.2XP_016883240.1  nuclear receptor coactivator 6 isoform X28

    UniProtKB/TrEMBL
    F6M2K2, F6M2K4
    Related
    ENSP00000481177.1, ENST00000612493.4
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  10. XM_047440057.1XP_047296013.1  nuclear receptor coactivator 6 isoform X17

  11. XM_047440050.1XP_047296006.1  nuclear receptor coactivator 6 isoform X7

  12. XM_017027742.3XP_016883231.1  nuclear receptor coactivator 6 isoform X3

  13. XM_047440066.1XP_047296022.1  nuclear receptor coactivator 6 isoform X31

    UniProtKB/TrEMBL
    F6M2K4
  14. XM_011528727.4XP_011527029.1  nuclear receptor coactivator 6 isoform X10

    Conserved Domains (2) summary
    pfam09606
    Location:427855
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48195
    Nucleic_acid_bd; Putative nucleic acid-binding region
  15. XM_047440065.1XP_047296021.1  nuclear receptor coactivator 6 isoform X30

    UniProtKB/TrEMBL
    F6M2K4
  16. XM_047440058.1XP_047296014.1  nuclear receptor coactivator 6 isoform X18

  17. XM_047440051.1XP_047296007.1  nuclear receptor coactivator 6 isoform X11

  18. XM_011528726.4XP_011527028.1  nuclear receptor coactivator 6 isoform X9

    Conserved Domains (2) summary
    pfam09606
    Location:427856
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48195
    Nucleic_acid_bd; Putative nucleic acid-binding region
  19. XM_047440063.1XP_047296019.1  nuclear receptor coactivator 6 isoform X27

    UniProtKB/TrEMBL
    F6M2K4
  20. XM_047440056.1XP_047296012.1  nuclear receptor coactivator 6 isoform X16

  21. XM_047440048.1XP_047296004.1  nuclear receptor coactivator 6 isoform X5

  22. XM_011528721.4XP_011527023.1  nuclear receptor coactivator 6 isoform X4

    See identical proteins and their annotated locations for XP_011527023.1

    Conserved Domains (2) summary
    pfam09606
    Location:427867
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48195
    Nucleic_acid_bd; Putative nucleic acid-binding region
  23. XM_047440061.1XP_047296017.1  nuclear receptor coactivator 6 isoform X25

    UniProtKB/TrEMBL
    F6M2K4
  24. XM_017027750.3XP_016883239.1  nuclear receptor coactivator 6 isoform X24

    UniProtKB/TrEMBL
    F6M2K4
  25. XM_017027748.2XP_016883237.1  nuclear receptor coactivator 6 isoform X23

  26. XM_017027743.3XP_016883232.1  nuclear receptor coactivator 6 isoform X8

  27. XM_017027741.2XP_016883230.1  nuclear receptor coactivator 6 isoform X2

  28. XM_017027739.2XP_016883228.1  nuclear receptor coactivator 6 isoform X1

  29. XM_047440053.1XP_047296009.1  nuclear receptor coactivator 6 isoform X13

  30. XM_047440049.1XP_047296005.1  nuclear receptor coactivator 6 isoform X6

    UniProtKB/Swiss-Prot
    A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
  31. XM_047440047.1XP_047296003.1  nuclear receptor coactivator 6 isoform X1

  32. XM_047440062.1XP_047296018.1  nuclear receptor coactivator 6 isoform X26

  33. XM_047440060.1XP_047296016.1  nuclear receptor coactivator 6 isoform X22

  34. XM_006723755.4XP_006723818.1  nuclear receptor coactivator 6 isoform X21

    See identical proteins and their annotated locations for XP_006723818.1

    UniProtKB/TrEMBL
    F6M2K3
    Conserved Domains (2) summary
    pfam09606
    Location:392803
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48190
    Nucleic_acid_bd; Putative nucleic acid-binding region
  35. XM_017027746.2XP_016883235.1  nuclear receptor coactivator 6 isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    36435437..36546294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323279.1XP_054179254.1  nuclear receptor coactivator 6 isoform X33

    UniProtKB/TrEMBL
    F6M2K4
  2. XM_054323261.1XP_054179236.1  nuclear receptor coactivator 6 isoform X15

  3. XM_054323258.1XP_054179233.1  nuclear receptor coactivator 6 isoform X13

  4. XM_054323278.1XP_054179253.1  nuclear receptor coactivator 6 isoform X32

    UniProtKB/TrEMBL
    F6M2K4
  5. XM_054323265.1XP_054179240.1  nuclear receptor coactivator 6 isoform X19

  6. XM_054323260.1XP_054179235.1  nuclear receptor coactivator 6 isoform X14

  7. XM_054323257.1XP_054179232.1  nuclear receptor coactivator 6 isoform X12

  8. XM_054323275.1XP_054179250.1  nuclear receptor coactivator 6 isoform X29

    UniProtKB/TrEMBL
    F6M2K4
  9. XM_054323274.1XP_054179249.1  nuclear receptor coactivator 6 isoform X28

    UniProtKB/TrEMBL
    F6M2K2, F6M2K4
  10. XM_054323263.1XP_054179238.1  nuclear receptor coactivator 6 isoform X17

  11. XM_054323252.1XP_054179227.1  nuclear receptor coactivator 6 isoform X7

  12. XM_054323248.1XP_054179223.1  nuclear receptor coactivator 6 isoform X3

  13. XM_054323277.1XP_054179252.1  nuclear receptor coactivator 6 isoform X31

    UniProtKB/TrEMBL
    F6M2K4
  14. XM_054323255.1XP_054179230.1  nuclear receptor coactivator 6 isoform X10

  15. XM_054323276.1XP_054179251.1  nuclear receptor coactivator 6 isoform X30

    UniProtKB/TrEMBL
    F6M2K4
  16. XM_054323264.1XP_054179239.1  nuclear receptor coactivator 6 isoform X18

  17. XM_054323256.1XP_054179231.1  nuclear receptor coactivator 6 isoform X11

  18. XM_054323254.1XP_054179229.1  nuclear receptor coactivator 6 isoform X9

  19. XM_054323273.1XP_054179248.1  nuclear receptor coactivator 6 isoform X27

    UniProtKB/TrEMBL
    F6M2K4
  20. XM_054323262.1XP_054179237.1  nuclear receptor coactivator 6 isoform X16

  21. XM_054323250.1XP_054179225.1  nuclear receptor coactivator 6 isoform X5

  22. XM_054323249.1XP_054179224.1  nuclear receptor coactivator 6 isoform X4

  23. XM_054323271.1XP_054179246.1  nuclear receptor coactivator 6 isoform X25

    UniProtKB/TrEMBL
    F6M2K4
  24. XM_054323270.1XP_054179245.1  nuclear receptor coactivator 6 isoform X24

    UniProtKB/TrEMBL
    F6M2K4
  25. XM_054323269.1XP_054179244.1  nuclear receptor coactivator 6 isoform X23

  26. XM_054323253.1XP_054179228.1  nuclear receptor coactivator 6 isoform X8

  27. XM_054323247.1XP_054179222.1  nuclear receptor coactivator 6 isoform X2

  28. XM_054323245.1XP_054179220.1  nuclear receptor coactivator 6 isoform X1

  29. XM_054323259.1XP_054179234.1  nuclear receptor coactivator 6 isoform X13

  30. XM_054323251.1XP_054179226.1  nuclear receptor coactivator 6 isoform X6

    UniProtKB/Swiss-Prot
    A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
  31. XM_054323246.1XP_054179221.1  nuclear receptor coactivator 6 isoform X1

  32. XM_054323272.1XP_054179247.1  nuclear receptor coactivator 6 isoform X26

  33. XM_054323268.1XP_054179243.1  nuclear receptor coactivator 6 isoform X22

  34. XM_054323267.1XP_054179242.1  nuclear receptor coactivator 6 isoform X21

    UniProtKB/TrEMBL
    F6M2K3
  35. XM_054323266.1XP_054179241.1  nuclear receptor coactivator 6 isoform X20