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Ncoa6 nuclear receptor coactivator 6 [ Mus musculus (house mouse) ]

Gene ID: 56406, updated on 27-Feb-2024

Summary

Official Symbol
Ncoa6provided by MGI
Official Full Name
nuclear receptor coactivator 6provided by MGI
Primary source
MGI:MGI:1929915
See related
Ensembl:ENSMUSG00000038369 AllianceGenome:MGI:1929915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRC; AIB3; ASC2; PRIP; ASC-2; Ncoa7; RAP250; mKIAA0181
Summary
Enables chromatin binding activity and transcription coactivator activity. Acts upstream of or within animal organ development; histone H3-K4 trimethylation; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.8), whole brain E14.5 (RPKM 15.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ncoa6 in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155232585..155315741, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155390656..155473911, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene transformation related protein 53 inducible nuclear protein 2 Neighboring gene ribosomal protein L8 pseudogene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene Neighboring gene cytochrome c, somatic pseudogene Neighboring gene gamma-glutamyltransferase 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90663

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin-protein adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone methyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear vitamin D receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor coactivator 6
Names
PPAR interacting protein PRIP
PPAR-interacting protein
activating signal cointegrator 2
amplified in breast cancer protein 3
cancer-amplified transcriptional coactivator ASC-2
nuclear receptor coactivator RAP250
nuclear receptor-activating protein 250
nuclear receptor-activating protein, 250 kDa
peroxisome proliferator-activated receptor interacting protein,PRIP
peroxisome proliferator-activated receptor-interacting protein
thyroid hormone receptor binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242558.2NP_001229487.1  nuclear receptor coactivator 6 isoform 2

    See identical proteins and their annotated locations for NP_001229487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as Ncoa6-beta) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AL844852, AL845325
    UniProtKB/TrEMBL
    F6M2J9, F6M2K1
    Conserved Domains (3) summary
    PHA03247
    Location:145550
    PHA03247; large tegument protein UL36; Provisional
    pfam09606
    Location:471864
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam13820
    Location:48189
    Nucleic_acid_bd; Putative nucleic acid-binding region
  2. NM_001406325.1NP_001393254.1  nuclear receptor coactivator 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844852, AL845325
    UniProtKB/Swiss-Prot
    Q9JL19, Q9JLT9
    UniProtKB/TrEMBL
    Q5XJV5
    Related
    ENSMUSP00000045386.6, ENSMUST00000043126.12
  3. NM_001406326.1NP_001393255.1  nuclear receptor coactivator 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL844852, AL845325
    UniProtKB/Swiss-Prot
    Q9JL19, Q9JLT9
    UniProtKB/TrEMBL
    Q5XJV5
  4. NM_019825.4NP_062799.2  nuclear receptor coactivator 6 isoform 1

    See identical proteins and their annotated locations for NP_062799.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1, also known as Ncoa6-alpha)
    Source sequence(s)
    AL844852, AL845325
    Consensus CDS
    CCDS38295.1
    UniProtKB/Swiss-Prot
    Q9JL19, Q9JLT9
    UniProtKB/TrEMBL
    Q5XJV5
    Related
    ENSMUSP00000105295.2, ENSMUST00000109670.8
    Conserved Domains (4) summary
    PHA03247
    Location:11731810
    PHA03247; large tegument protein UL36; Provisional
    pfam09606
    Location:471864
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam08580
    Location:10821326
    KAR9; Yeast cortical protein KAR9
    pfam13820
    Location:48189
    Nucleic_acid_bd; Putative nucleic acid-binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155232585..155315741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)