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RBM34 RNA binding motif protein 34 [ Homo sapiens (human) ]

Gene ID: 23029, updated on 5-Sep-2021

Summary

Official Symbol
RBM34provided by HGNC
Official Full Name
RNA binding motif protein 34provided by HGNC
Primary source
HGNC:HGNC:28965
See related
Ensembl:ENSG00000188739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the RNA-binding motif family of RNA recognition motif proteins. The encoded protein contains an RNA-binding domain made up of two RNA recognition motif subdomains referred to as RNA recognition motif-1 and RNA recognition motif-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in testis (RPKM 15.6), lymph node (RPKM 10.7) and 25 other tissues See more
Orthologs
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Genomic context

See RBM34 in Genome Data Viewer
Location:
1q42.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (235131183..235161280, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (235294498..235324565, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985746 Neighboring gene uncharacterized LOC105379283 Neighboring gene translocase of outer mitochondrial membrane 20 Neighboring gene small nucleolar RNA, H/ACA box 14B Neighboring gene AT-rich interaction domain 4B Neighboring gene microRNA 4753 Neighboring gene Sharpr-MPRA regulatory region 13312

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of RNA binding motif protein 34 (RBM34) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
RNA-binding protein 34
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346738.2NP_001333667.1  RNA-binding protein 34 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1
    Source sequence(s)
    AK292362, AL133418, AL732292, BM995796, DB045266
    UniProtKB/Swiss-Prot
    P42696
  2. NM_015014.4NP_055829.2  RNA-binding protein 34 isoform 1

    See identical proteins and their annotated locations for NP_055829.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC029451, BM995796
    Consensus CDS
    CCDS41477.2
    UniProtKB/Swiss-Prot
    P42696
    Related
    ENSP00000386226.3, ENST00000408888.8
    Conserved Domains (3) summary
    COG0724
    Location:176382
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12394
    Location:185276
    RRM1_RBM34; RNA recognition motif 1 in RNA-binding protein 34 (RBM34) and similar proteins
    cd12395
    Location:288360
    RRM2_RBM34; RNA recognition motif 2 in RNA-binding protein 34 (RBM34) and similar proteins

RNA

  1. NR_027762.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL133418, AL732292, BM995796
  2. NR_144490.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) retains an intron in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK292362, AL133418, AL732292, BM995796, DB045266
  3. NR_144491.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an internal exon and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK292362, AL133418, AL732292, BM995796, DB045266
  4. NR_144492.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) retains an intron in the 5' region and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK292362, AL133418, AL732292, BM995796, DB045266

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    235131183..235161280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544133.2XP_011542435.1  RNA-binding protein 34 isoform X1

    Related
    ENSP00000400000.1, ENST00000447801.5
    Conserved Domains (3) summary
    COG0724
    Location:258362
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12395
    Location:268340
    RRM2_RBM34; RNA recognition motif 2 in RNA-binding protein 34 (RBM34) and similar proteins
    cl17169
    Location:185256
    RRM_SF; RNA recognition motif (RRM) superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001161533.1: Suppressed sequence

    Description
    NM_001161533.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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