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Clca2 chloride channel accessory 2 [ Mus musculus (house mouse) ]

Gene ID: 229933, updated on 7-May-2024

Summary

Official Symbol
Clca2provided by MGI
Official Full Name
chloride channel accessory 2provided by MGI
Primary source
MGI:MGI:2139758
See related
Ensembl:ENSMUSG00000036960 AllianceGenome:MGI:2139758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clca5; 4732440A06
Summary
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. Mice lacking a functional copy of this gene exhibit increased liver weight and hepatocyte hypertrophy. [provided by RefSeq, Sep 2016]
Expression
Biased expression in bladder adult (RPKM 1.1), subcutaneous fat pad adult (RPKM 0.8) and 11 other tissues See more
Orthologs
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Genomic context

See Clca2 in Genome Data Viewer
Location:
3 H2; 3 69.31 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144776021..144805204, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145070260..145099443, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chloride channel accessory 4A Neighboring gene predicted gene, 35066 Neighboring gene STARR-seq mESC enhancer starr_09188 Neighboring gene chloride channel accessory 1 Neighboring gene STARR-seq mESC enhancer starr_09190 Neighboring gene STARR-seq mESC enhancer starr_09191 Neighboring gene STARR-positive B cell enhancer ABC_E1637 Neighboring gene predicted gene, 40163 Neighboring gene STARR-positive B cell enhancer mm9_chr3:144794197-144794498 Neighboring gene outer dense fiber of sperm tails 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ligand-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated monoatomic ion channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium-activated chloride channel regulator 2
Names
calcium-activated chloride channel family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409792.1NP_001396721.1  calcium-activated chloride channel regulator 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC152400
    Related
    ENSMUSP00000143161.2, ENSMUST00000198993.2
  2. NM_178697.6NP_848812.1  calcium-activated chloride channel regulator 2 isoform 1

    See identical proteins and their annotated locations for NP_848812.1

    Status: REVIEWED

    Source sequence(s)
    AC152400
    Consensus CDS
    CCDS17890.1
    UniProtKB/Swiss-Prot
    Q8BG22, Q8BZF7
    Related
    ENSMUSP00000036029.7, ENSMUST00000040465.11
    Conserved Domains (2) summary
    cd00198
    Location:310466
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam08434
    Location:34893
    CLCA; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    144776021..144805204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501432.4XP_006501495.1  calcium-activated chloride channel regulator 2 isoform X1

    Conserved Domains (1) summary
    TIGR00868
    Location:1818
    hCaCC; calcium-activated chloride channel protein 1
  2. XM_006501433.1XP_006501496.1  calcium-activated chloride channel regulator 2 isoform X2

    Conserved Domains (1) summary
    TIGR00868
    Location:11689
    hCaCC; calcium-activated chloride channel protein 1