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CLCA2 chloride channel accessory 2 [ Homo sapiens (human) ]

Gene ID: 9635, updated on 1-Jun-2020

Summary

Official Symbol
CLCA2provided by HGNC
Official Full Name
chloride channel accessory 2provided by HGNC
Primary source
HGNC:HGNC:2016
See related
Ensembl:ENSG00000137975 MIM:604003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACC; CACC3; CLCRG2; CaCC-3
Summary
This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. [provided by RefSeq, Sep 2016]
Expression
Biased expression in esophagus (RPKM 67.2), skin (RPKM 43.6) and 1 other tissue See more
Orthologs

Genomic context

See CLCA2 in Genome Data Viewer
Location:
1p22.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (86424144..86456553)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86889769..86922241)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene outer dense fiber of sperm tails 2 like Neighboring gene microRNA 7856 Neighboring gene ribosomal protein L7 like 1 pseudogene Neighboring gene chloride channel accessory 1 Neighboring gene uncharacterized LOC105378827

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ97885

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chloride channel activity TAS
Traceable Author Statement
more info
PubMed 
intracellular calcium activated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
calcium-activated chloride channel regulator 2
Names
CLCA family member 2, chloride channel regulator
calcium-activated chloride channel protein 3
chloride channel, calcium activated, family member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006536.7NP_006527.1  calcium-activated chloride channel regulator 2 preproprotein

    See identical proteins and their annotated locations for NP_006527.1

    Status: REVIEWED

    Source sequence(s)
    BC041096, DC417810
    Consensus CDS
    CCDS708.1
    UniProtKB/Swiss-Prot
    Q9UQC9
    Related
    ENSP00000359596.4, ENST00000370565.5
    Conserved Domains (1) summary
    cl26751
    Location:33896
    CLCA; Calcium-activated chloride channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    86424144..86456553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542448.3XP_011540750.1  calcium-activated chloride channel regulator 2 isoform X1

    Conserved Domains (3) summary
    cd00198
    Location:312466
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam08434
    Location:33571
    CLCA; Calcium-activated chloride channel
    cl01053
    Location:77119
    SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
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