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ZBTB1 zinc finger and BTB domain containing 1 [ Homo sapiens (human) ]

Gene ID: 22890, updated on 6-Sep-2022

Summary

Official Symbol
ZBTB1provided by HGNC
Official Full Name
zinc finger and BTB domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20259
See related
Ensembl:ENSG00000126804 MIM:616578; AllianceGenome:HGNC:20259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF909
Summary
Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including cellular response to UV; nucleobase-containing compound biosynthetic process; and protein homooligomerization. Located in centrosome; nuclear body; and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 14.1), lymph node (RPKM 11.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB1 in Genome Data Viewer
Location:
14q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64503716..64533693)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58712530..58741460)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64971488..65000411)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 9441 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene protein phosphatase 1 regulatory subunit 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0997

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell mediated immunity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of pro-T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in translesion synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123329.2NP_001116801.1  zinc finger and BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001116801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AW965994, BC050719, BM975910, BX248777
    Consensus CDS
    CCDS45126.1
    UniProtKB/Swiss-Prot
    Q86SW8, Q9Y2K1
    Related
    ENSP00000506911.1, ENST00000683701.1
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  2. NM_014950.3NP_055765.2  zinc finger and BTB domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_055765.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' coding region and 3' UTR, compared to variant 1. This results in a shorter isoform (2) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB023214, AL049869, BX248777, CN362091
    Consensus CDS
    CCDS32097.1
    UniProtKB/Swiss-Prot
    Q9Y2K1
    Related
    ENSP00000351587.3, ENST00000358738.3
    Conserved Domains (2) summary
    sd00017
    Location:536574
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64503716..64533693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431111.1XP_047287067.1  zinc finger and BTB domain-containing protein 1 isoform X2

  2. XM_047431093.1XP_047287049.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  3. XM_047431095.1XP_047287051.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  4. XM_047431098.1XP_047287054.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  5. XM_047431091.1XP_047287047.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  6. XM_047431106.1XP_047287062.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  7. XM_047431100.1XP_047287056.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  8. XM_047431107.1XP_047287063.1  zinc finger and BTB domain-containing protein 1 isoform X2

  9. XM_047431092.1XP_047287048.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  10. XM_047431088.1XP_047287044.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  11. XM_047431102.1XP_047287058.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
    Related
    ENSP00000451000.1, ENST00000554015.5
  12. XM_047431086.1XP_047287042.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  13. XM_047431096.1XP_047287052.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  14. XM_047431090.1XP_047287046.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  15. XM_047431104.1XP_047287060.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  16. XM_047431097.1XP_047287053.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  17. XM_047431087.1XP_047287043.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  18. XM_047431108.1XP_047287064.1  zinc finger and BTB domain-containing protein 1 isoform X2

  19. XM_047431110.1XP_047287066.1  zinc finger and BTB domain-containing protein 1 isoform X2

  20. XM_047431103.1XP_047287059.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  21. XM_005267410.2XP_005267467.1  zinc finger and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267467.1

    UniProtKB/Swiss-Prot
    Q86SW8, Q9Y2K1
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  22. XM_017021095.2XP_016876584.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8, Q9Y2K1
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  23. XM_011536566.3XP_011534868.1  zinc finger and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011534868.1

    UniProtKB/Swiss-Prot
    Q86SW8, Q9Y2K1
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
  24. XM_047431094.1XP_047287050.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  25. XM_047431105.1XP_047287061.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8
  26. XM_047431101.1XP_047287057.1  zinc finger and BTB domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q86SW8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    58712530..58741460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)