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Zbtb1 zinc finger and BTB domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 268564, updated on 12-May-2024

Summary

Official Symbol
Zbtb1provided by MGI
Official Full Name
zinc finger and BTB domain containing 1provided by MGI
Primary source
MGI:MGI:2442326
See related
Ensembl:ENSMUSG00000033454 AllianceGenome:MGI:2442326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bsg2; 9430077A12; C430003J21Rik
Summary
Enables protein homodimerization activity. Involved in positive regulation of T cell mediated immunity; positive regulation of lymphocyte differentiation; and thymus development. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Predicted to be located in centrosome; nuclear body; and nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cerebral cortex; female reproductive system; trigeminal ganglion; and urinary system. Orthologous to human ZBTB1 (zinc finger and BTB domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 4.3), ovary adult (RPKM 4.1) and 28 other tissues See more
Orthologs
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Genomic context

See Zbtb1 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76416825..76443729)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76370051..76396955)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Neighboring gene predicted gene, 40443 Neighboring gene A kinase anchor protein 5 Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene STARR-seq mESC enhancer starr_32516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468237-77468545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:77468685-77468794 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene STARR-positive B cell enhancer ABC_E94 Neighboring gene STARR-seq mESC enhancer starr_32522 Neighboring gene heat shock protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene, 25563

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell mediated immunity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pro-T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 1
Names
brain specific protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364323.1NP_001351252.1  zinc finger and BTB domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124453
    UniProtKB/TrEMBL
    Q3V277
    Conserved Domains (3) summary
    sd00017
    Location:536574
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
    pfam13465
    Location:592617
    zf-H2C2_2; Zinc-finger double domain
  2. NM_178744.3NP_848859.1  zinc finger and BTB domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_848859.1

    Status: VALIDATED

    Source sequence(s)
    AC124453, BQ032048
    Consensus CDS
    CCDS25992.1
    UniProtKB/Swiss-Prot
    Q8CDP7, Q91VL9, Q99LD2
    UniProtKB/TrEMBL
    Q3V277, Q5YB37
    Related
    ENSMUSP00000041955.4, ENSMUST00000042779.4
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76416825..76443729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515898.3XP_006515961.1  zinc finger and BTB domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    Q3V277
    Conserved Domains (3) summary
    sd00017
    Location:536574
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)
    pfam13465
    Location:592617
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006515895.4XP_006515958.1  zinc finger and BTB domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006515958.1

    UniProtKB/Swiss-Prot
    Q8CDP7, Q91VL9, Q99LD2
    UniProtKB/TrEMBL
    Q3V277, Q5YB37
    Conserved Domains (3) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:688709
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18192
    Location:3116
    BTB_POZ_ZBTB1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1)

RNA

  1. XR_872712.2 RNA Sequence

  2. XR_381523.3 RNA Sequence