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Zfpm1 zinc finger protein, multitype 1 [ Mus musculus (house mouse) ]

Gene ID: 22761, updated on 14-May-2024

Summary

Official Symbol
Zfpm1provided by MGI
Official Full Name
zinc finger protein, multitype 1provided by MGI
Primary source
MGI:MGI:1095400
See related
Ensembl:ENSMUSG00000049577 AllianceGenome:MGI:1095400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FOG; Fog1
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic hemopoiesis; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including myeloid cell differentiation; regulation of chemokine production; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Orthologous to human ZFPM1 (zinc finger protein, FOG family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 90.0), small intestine adult (RPKM 68.4) and 20 other tissues See more
Orthologs
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Genomic context

See Zfpm1 in Genome Data Viewer
Location:
8 E1; 8 70.86 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123008595..123064601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122281856..122337862)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 469 Neighboring gene STARR-seq mESC enhancer starr_22941 Neighboring gene predicted gene, 34413 Neighboring gene STARR-seq mESC enhancer starr_22942 Neighboring gene predicted gene, 39268 Neighboring gene Zfpm1R1 and Zfpm1R2 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E8268 Neighboring gene STARR-seq mESC enhancer starr_22944 Neighboring gene Zfpm1R7 and Zfpm1R21 erythroid cis-regulatory modules Neighboring gene STARR-positive B cell enhancer ABC_E6695 Neighboring gene STARR-positive B cell enhancer ABC_E2277 Neighboring gene STARR-positive B cell enhancer ABC_E6696 Neighboring gene Zfpm1R13 and Zfpm1R24 erythroid cis-regulatory modules Neighboring gene predicted gene, 39269 Neighboring gene Zfpm1R19 and Zfpm1R14 erythroid cis-regulatory modules Neighboring gene STARR-seq mESC enhancer starr_22945 Neighboring gene Zfpm1R6 erythroid cis-regulatory module Neighboring gene Zfpm1R18 erythroid cis-regulatory module Neighboring gene Zfpm1R10 erythroid cis-regulatory module Neighboring gene Zfpm1R12 erythroid cis-regulatory module Neighboring gene STARR-positive B cell enhancer ABC_E6697 Neighboring gene predicted gene, 46056 Neighboring gene thyrotropin releasing hormone receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in atrial septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in megakaryocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within megakaryocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitral valve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mast cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of definitive erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in tricuspid valve formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein ZFPM1
Names
FOG-1
Friend of GATA 1
friend of GATA protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009569.4NP_033595.1  zinc finger protein ZFPM1

    See identical proteins and their annotated locations for NP_033595.1

    Status: VALIDATED

    Source sequence(s)
    AC121976
    Consensus CDS
    CCDS22733.1
    UniProtKB/Swiss-Prot
    O35615
    Related
    ENSMUSP00000058037.9, ENSMUST00000054052.15
    Conserved Domains (6) summary
    PHA00733
    Location:332387
    PHA00733; hypothetical protein
    PHA03247
    Location:398581
    PHA03247; large tegument protein UL36; Provisional
    PRK14951
    Location:789941
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:308327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd19215
    Location:101209
    PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123008595..123064601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243422.1XP_030099282.1  zinc finger protein ZFPM1 isoform X2

    Conserved Domains (6) summary
    PHA00733
    Location:314369
    PHA00733; hypothetical protein
    PHA03247
    Location:380563
    PHA03247; large tegument protein UL36; Provisional
    PRK14951
    Location:771923
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:290309
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:301326
    zf-H2C2_2; Zinc-finger double domain
    cd19215
    Location:83191
    PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins
  2. XM_006530851.5XP_006530914.1  zinc finger protein ZFPM1 isoform X1

    See identical proteins and their annotated locations for XP_006530914.1

    UniProtKB/Swiss-Prot
    O35615
    Conserved Domains (6) summary
    PHA00733
    Location:332387
    PHA00733; hypothetical protein
    PHA03247
    Location:398581
    PHA03247; large tegument protein UL36; Provisional
    PRK14951
    Location:789941
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    sd00017
    Location:308327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd19215
    Location:101209
    PR-SET_ZFPM1; PR-SET domain found in zinc finger protein ZFPM1 and similar proteins