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ZFPM1 zinc finger protein, FOG family member 1 [ Homo sapiens (human) ]

Gene ID: 161882, updated on 7-Dec-2018

Summary

Official Symbol
ZFPM1provided by HGNC
Official Full Name
zinc finger protein, FOG family member 1provided by HGNC
Primary source
HGNC:HGNC:19762
See related
Ensembl:ENSG00000179588 MIM:601950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A
Expression
Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues See more
Orthologs

Genomic context

See ZFPM1 in Genome Data Viewer
Location:
16q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (88451782..88535166)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88520014..88601574)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984862 Neighboring gene uncharacterized LOC112268182 Neighboring gene zinc finger protein 469 Neighboring gene microRNA 5189 Neighboring gene uncharacterized LOC107984890 Neighboring gene uncharacterized LOC100128882 Neighboring gene uncharacterized LOC107984905 Neighboring gene ZC3H18 antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
T-helper cell lineage commitment IC
Inferred by Curator
more info
PubMed 
atrial septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
atrioventricular valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
definitive erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
granulocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
megakaryocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitral valve formation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet formation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
primitive erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
regulation of definitive erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
transcriptional activation by promoter-enhancer looping ISS
Inferred from Sequence or Structural Similarity
more info
 
tricuspid valve formation ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein ZFPM1
Names
FOG-1
friend of GATA 1
friend of GATA protein 1
zinc finger protein 89A
zinc finger protein, multitype 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153813.3NP_722520.2  zinc finger protein ZFPM1

    See identical proteins and their annotated locations for NP_722520.2

    Status: VALIDATED

    Source sequence(s)
    AC116552, AC135049, AF488691, BE219988
    Consensus CDS
    CCDS32502.1
    UniProtKB/Swiss-Prot
    Q8IX07
    Related
    ENSP00000326630.2, ENST00000319555.7
    Conserved Domains (3) summary
    sd00017
    Location:295314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:456549
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    88451782..88535166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522914.2XP_011521216.1  zinc finger protein ZFPM1 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:328347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:489582
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:339364
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011522912.2XP_011521214.1  zinc finger protein ZFPM1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:341360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:502595
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:352377
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017022982.1XP_016878471.1  zinc finger protein ZFPM1 isoform X4

  4. XM_011522917.2XP_011521219.1  zinc finger protein ZFPM1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:235254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:396489
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:246271
    zf-H2C2_2; Zinc-finger double domain
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