ZFPM1 zinc finger protein, FOG family member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZFPM1provided by HGNC
Official Full Name: zinc finger protein, FOG family member 1provided by HGNC
Primary source: HGNC:HGNC:19762
See related: Ensembl:ENSG00000179588 MIM:601950; AllianceGenome:HGNC:19762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q24.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (88451769..88537031)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (94519763..94605071)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (88519688..88603439)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The upregulation of Gata transcription factors family and FOG-1 in expanded and differentiated cord blood-derived CD34[+] hematopoietic stem cells to megakaryocyte lineage during co-culture with cord blood mesenchymal stem cells.
Title: The upregulation of Gata transcription factors family and FOG-1 in expanded and differentiated cord blood-derived CD34(+) hematopoietic stem cells to megakaryocyte lineage during co-culture with cord blood mesenchymal stem cells.
Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/beta-Catenin Axis.
Title: Long Noncoding RNA ZFPM2-AS1 Knockdown Restrains the Development of Retinoblastoma by Modulating the MicroRNA-515/HOXA1/Wnt/β-Catenin Axis.
Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 protein, but repressed that of transcription factor PU.1.
Title: Forced FOG1 expression in erythroleukemia cells: Induction of erythroid genes and repression of myelo-lymphoid transcription factor PU.1.
GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.
Title: Identification of four new susceptibility loci for testicular germ cell tumour.
FOG1 is a member of the PR domain containing, zinc finger protein family of transcriptional regulators.
Title: The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.
Our results reveal that the protein structure does not affect ligand binding, and the top three TCM candidates Bittersweet alkaloid II, Eicosandioic acid, and Perivine might resolve the instability of the RbAp48-FOG1 complex
Title: Lead discovery for Alzheimer's disease related target protein RbAp48 from traditional Chinese medicine.
FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation.
Title: Friend of GATA and GATA-6 modulate the transcriptional up-regulation of hepcidin in hepatocytes during inflammation.
ZFPM1 that facilitates human Th1 differentiation via the downregulation of IL-4 is a potential target for the treatment of allergic diseases.
Title: Zinc finger protein, multitype 1, suppresses human Th2 development via downregulation of IL-4.
Anagrelide suppresses megakaryocytopoiesis by reducing the expression levels of GATA-1 and FOG-1 via a PDEIII-independent mechanism that is differentiation context-specific and does not involve inhibition of MPL-mediated early signal transduction events
Title: Anagrelide represses GATA-1 and FOG-1 expression without interfering with thrombopoietin receptor signal transduction.
The FOG-1 peptide contacts a negatively charged binding pocket on top of the RbAp48 beta-propeller that is distinct from the binding surface used by RpAp48 to contact histone H4
Title: Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48·FOG-1 complex.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH47756 (e-PCR)
- UniSTS:25655

G60367 (e-PCR)
- UniSTS:137623

D16S3023 (e-PCR), detects polymorphism
- UniSTS:38361

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper cell lineage commitment	IC Inferred by Curator more info	PubMed
involved_in atrial septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in atrioventricular valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in definitive erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in embryonic hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in granulocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in megakaryocyte development	IEA Inferred from Electronic Annotation more info
involved_in megakaryocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitral valve formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in outflow tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in primitive erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in regulation of definitive erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of definitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricuspid valve formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ventricular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein ZFPM1

Names: FOG-1; friend of GATA 1; friend of GATA protein 1; zinc finger protein 89A; zinc finger protein, multitype 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153813.3 → NP_722520.2 zinc finger protein ZFPM1

See identical proteins and their annotated locations for NP_722520.2

Status: VALIDATED

Source sequence(s)

AC116552, AC135049, AF488691, BE219988

Consensus CDS

CCDS32502.1

UniProtKB/Swiss-Prot

Q8IX07

Related

ENSP00000326630.2, ENST00000319555.8

Conserved Domains (3) summary

sd00017
Location:295 → 314

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05843
Location:456 → 549

Suf; Suppressor of forked protein (Suf)

pfam13465
Location:306 → 331

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

88451769..88537031

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011522914.3 → XP_011521216.1 zinc finger protein ZFPM1 isoform X2

Conserved Domains (3) summary

sd00017
Location:328 → 347

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05843
Location:489 → 582

Suf; Suppressor of forked protein (Suf)

pfam13465
Location:339 → 364

zf-H2C2_2; Zinc-finger double domain
XM_047433667.1 → XP_047289623.1 zinc finger protein ZFPM1 isoform X3
XM_011522912.3 → XP_011521214.1 zinc finger protein ZFPM1 isoform X1

Conserved Domains (3) summary

sd00017
Location:341 → 360

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05843
Location:502 → 595

Suf; Suppressor of forked protein (Suf)

pfam13465
Location:352 → 377

zf-H2C2_2; Zinc-finger double domain
XM_017022982.2 → XP_016878471.1 zinc finger protein ZFPM1 isoform X5
XM_011522917.3 → XP_011521219.1 zinc finger protein ZFPM1 isoform X4

Conserved Domains (3) summary

sd00017
Location:235 → 254

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05843
Location:396 → 489

Suf; Suppressor of forked protein (Suf)

pfam13465
Location:246 → 271

zf-H2C2_2; Zinc-finger double domain