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ZFPM1 zinc finger protein, FOG family member 1 [ Homo sapiens (human) ]

Gene ID: 161882, updated on 17-Jun-2024

Summary

Official Symbol
ZFPM1provided by HGNC
Official Full Name
zinc finger protein, FOG family member 1provided by HGNC
Primary source
HGNC:HGNC:19762
See related
Ensembl:ENSG00000179588 MIM:601950; AllianceGenome:HGNC:19762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See ZFPM1 in Genome Data Viewer
Location:
16q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (88451769..88537031)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (94519763..94605071)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88519688..88603439)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 469 Neighboring gene uncharacterized LOC124900374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88294229-88295094 Neighboring gene uncharacterized LOC107984862 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:88298191-88299390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88305120-88305626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88308260-88309065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88337429-88337930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88338969-88339468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88342417-88342918 Neighboring gene Sharpr-MPRA regulatory region 14328 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:88366225-88367424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88383362-88384329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88447094-88447638 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88448183-88448726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88463994-88464796 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:88476410-88477609 Neighboring gene uncharacterized LOC112268182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88499412-88499912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88509531-88510396 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:88513905-88514141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11352 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:88526556-88527059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88528211-88529126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88544251-88545176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88545177-88546101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88546568-88547068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88547069-88547569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88549643-88550148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88550149-88550654 Neighboring gene microRNA 5189 Neighboring gene uncharacterized LOC107984890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88574841-88575346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:88576357-88576860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88591868-88592455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88592456-88593042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88594011-88594750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88593270-88594010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88599832-88600392 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:88600393-88600954 Neighboring gene ZFPM1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88606102-88606704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7857 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11356 Neighboring gene ZC3H18 antisense RNA 1 (head to head) Neighboring gene Sharpr-MPRA regulatory region 13594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11357 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:88673559-88674059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88676553-88677498 Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88694002-88694718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:88694719-88695433

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T-helper cell lineage commitment IC
Inferred by Curator
more info
PubMed 
involved_in atrial septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in atrioventricular valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac muscle tissue morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in definitive erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in granulocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in megakaryocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in megakaryocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitral valve formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in platelet formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in primitive erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of definitive erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tricuspid valve formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein ZFPM1
Names
FOG-1
friend of GATA 1
friend of GATA protein 1
zinc finger protein 89A
zinc finger protein, multitype 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153813.3NP_722520.2  zinc finger protein ZFPM1

    See identical proteins and their annotated locations for NP_722520.2

    Status: VALIDATED

    Source sequence(s)
    AC116552, AC135049, AF488691, BE219988
    Consensus CDS
    CCDS32502.1
    UniProtKB/Swiss-Prot
    Q8IX07
    Related
    ENSP00000326630.2, ENST00000319555.8
    Conserved Domains (3) summary
    sd00017
    Location:295314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:456549
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    88451769..88537031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522914.3XP_011521216.1  zinc finger protein ZFPM1 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:328347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:489582
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:339364
    zf-H2C2_2; Zinc-finger double domain
  2. XM_047433667.1XP_047289623.1  zinc finger protein ZFPM1 isoform X3

  3. XM_011522912.3XP_011521214.1  zinc finger protein ZFPM1 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:341360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:502595
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:352377
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017022982.2XP_016878471.1  zinc finger protein ZFPM1 isoform X5

  5. XM_011522917.3XP_011521219.1  zinc finger protein ZFPM1 isoform X4

    Conserved Domains (3) summary
    sd00017
    Location:235254
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05843
    Location:396489
    Suf; Suppressor of forked protein (Suf)
    pfam13465
    Location:246271
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    94519763..94605071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379704.1XP_054235679.1  zinc finger protein ZFPM1 isoform X2

  2. XM_054379705.1XP_054235680.1  zinc finger protein ZFPM1 isoform X3

  3. XM_054379703.1XP_054235678.1  zinc finger protein ZFPM1 isoform X1

  4. XM_054379707.1XP_054235682.1  zinc finger protein ZFPM1 isoform X5

  5. XM_054379706.1XP_054235681.1  zinc finger protein ZFPM1 isoform X4