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Zfp46 zinc finger protein 46 [ Mus musculus (house mouse) ]

Gene ID: 22704, updated on 11-Apr-2024

Summary

Official Symbol
Zfp46provided by MGI
Official Full Name
zinc finger protein 46provided by MGI
Primary source
MGI:MGI:99192
See related
Ensembl:ENSMUSG00000051351 AllianceGenome:MGI:99192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlz-4; Zfp-46; Znf436
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in ganglia; genitourinary system; and hindbrain. Orthologous to human ZNF436 (zinc finger protein 436). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 13.1), whole brain E14.5 (RPKM 12.7) and 28 other tissues See more
Orthologs
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Genomic context

See Zfp46 in Genome Data Viewer
Location:
4 D3; 4 68.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136011479..136021163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136284168..136293942)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 436
Names
zinc finger protein MLZ-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356308.2NP_001343237.1  zinc finger protein 436 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Consensus CDS
    CCDS18804.1
    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
    Conserved Domains (3) summary
    smart00349
    Location:164
    KRAB; krueppel associated box
    COG5048
    Location:145452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001370651.2NP_001357580.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Conserved Domains (3) summary
    COG5048
    Location:163470
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box
  3. NM_001425037.1NP_001411966.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL935264
  4. NM_001425038.1NP_001411967.1  zinc finger protein 436 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL935264
    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
  5. NM_009557.5NP_033583.2  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_033583.2

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Consensus CDS
    CCDS18804.1
    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
    Related
    ENSMUSP00000070216.5, ENSMUST00000069195.5
    Conserved Domains (3) summary
    smart00349
    Location:164
    KRAB; krueppel associated box
    COG5048
    Location:145452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136011479..136021163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163984.1XP_036019877.1  zinc finger protein 436 isoform X2

    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
    Conserved Domains (3) summary
    smart00349
    Location:164
    KRAB; krueppel associated box
    COG5048
    Location:145452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006538728.1XP_006538791.1  zinc finger protein 436 isoform X1

    See identical proteins and their annotated locations for XP_006538791.1

    Conserved Domains (3) summary
    COG5048
    Location:163470
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box