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ZNF436 zinc finger protein 436 [ Homo sapiens (human) ]

Gene ID: 80818, updated on 13-Mar-2020

Summary

Official Symbol
ZNF436provided by HGNC
Official Full Name
zinc finger protein 436provided by HGNC
Primary source
HGNC:HGNC:20814
See related
Ensembl:ENSG00000125945 MIM:611703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; Zfp46
Expression
Ubiquitous expression in ovary (RPKM 11.7), brain (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF436 in Genome Data Viewer
Location:
1p36.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23359448..23369836, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23685941..23696357, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene MIR1 retrotransposon enhancer-blocking element Neighboring gene ZNF436 antisense RNA 1 Neighboring gene transcription elongation factor A3 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 436 (ZNF436) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 436
Names
DNA-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077195.2NP_001070663.1  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_001070663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB051497, AL109936
    Consensus CDS
    CCDS233.1
    UniProtKB/Swiss-Prot
    Q9C0F3
    UniProtKB/TrEMBL
    A0A024RAF3
    Related
    ENSP00000313582.4, ENST00000314011.9
    Conserved Domains (4) summary
    COG5048
    Location:212467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box
    pfam13465
    Location:152177
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001370652.1NP_001357581.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109936
    Conserved Domains (5) summary
    smart00349
    Location:153
    KRAB; krueppel associated box
    COG5048
    Location:194449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:120142
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:134159
    zf-H2C2_2; Zinc-finger double domain
  3. NM_030634.2NP_085137.1  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_085137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL109936, AL834485
    Consensus CDS
    CCDS233.1
    UniProtKB/Swiss-Prot
    Q9C0F3
    UniProtKB/TrEMBL
    A0A024RAF3
    Related
    ENSP00000363736.3, ENST00000374608.3
    Conserved Domains (4) summary
    COG5048
    Location:212467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box
    pfam13465
    Location:152177
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23359448..23369836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p13 PATCHES

    Range
    129427..139815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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