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Trio triple functional domain (PTPRF interacting) [ Mus musculus (house mouse) ]

Gene ID: 223435, updated on 27-Nov-2024

Summary

Official Symbol
Trioprovided by MGI
Official Full Name
triple functional domain (PTPRF interacting)provided by MGI
Primary source
MGI:MGI:1927230
See related
Ensembl:ENSMUSG00000022263 AllianceGenome:MGI:1927230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Solo; 6720464I07Rik
Summary
Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of fat cell differentiation. Predicted to be located in cell projection and early endosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic active zone. Predicted to be extrinsic component of membrane. Is expressed in central nervous system and dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal dominant intellectual developmental disorder 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 17.6), CNS E18 (RPKM 15.5) and 28 other tissues See more
Orthologs
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Genomic context

See Trio in Genome Data Viewer
Location:
15 B1; 15 10.4 cM
Exon count:
62
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (27730735..28025954, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (27730649..28025848, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46506 Neighboring gene STARR-seq mESC enhancer starr_38229 Neighboring gene OTU deubiquitinase with linear linkage specificity like Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:27725815-27725968 Neighboring gene STARR-positive B cell enhancer ABC_E11588 Neighboring gene STARR-seq mESC enhancer starr_38230 Neighboring gene STARR-seq mESC enhancer starr_38231 Neighboring gene STARR-seq mESC enhancer starr_38233 Neighboring gene STARR-positive B cell enhancer ABC_E5471 Neighboring gene STARR-seq mESC enhancer starr_38236 Neighboring gene STARR-seq mESC enhancer starr_38238 Neighboring gene STARR-seq mESC enhancer starr_38239 Neighboring gene STARR-seq mESC enhancer starr_38240 Neighboring gene STARR-seq mESC enhancer starr_38241 Neighboring gene predicted gene, 29975 Neighboring gene STARR-seq mESC enhancer starr_38243 Neighboring gene STARR-seq mESC enhancer starr_38244 Neighboring gene predicted gene, 19883 Neighboring gene predicted gene, 31458

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (7)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
triple functional domain protein
NP_001074771.1
XP_006520113.1
XP_006520114.1
XP_006520115.1
XP_006520116.1
XP_006520117.1
XP_030104327.1
XP_036015215.1
XP_036015216.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081302.1NP_001074771.1  triple functional domain protein

    Status: VALIDATED

    Source sequence(s)
    AB106872, BC051169, BC060724, BY727751, CF539743
    Consensus CDS
    CCDS49587.1
    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Related
    ENSMUSP00000087714.6, ENSMUST00000090247.7
    Conserved Domains (14) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16591718
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25592617
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00220
    Location:28003054
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00516
    Location:69204
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19702143
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:567783
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam07679
    Location:26892780
    I-set; Immunoglobulin I-set domain
    cd13240
    Location:14721594
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21482286
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27923054
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam00169
    Location:21752271
    PH; PH domain
    pfam16609
    Location:17151972
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cl11960
    Location:27032780
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    27730735..28025954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520051.5XP_006520114.1  triple functional domain protein isoform X2

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (11) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16591718
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25592617
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:69204
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19702143
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:567783
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14721594
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21482286
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27883050
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:26852776
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17161963
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  2. XM_036159323.1XP_036015216.1  triple functional domain protein isoform X7

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (12) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16591718
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25592617
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:69204
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19702143
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:567783
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14721594
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21482286
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam07679
    Location:26892780
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17151972
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:26972700
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:27922875
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006520053.5XP_006520116.1  triple functional domain protein isoform X5

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (11) summary
    smart00150
    Location:11041204
    SPEC; Spectrin repeats
    cd11852
    Location:16201679
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25202578
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:30165
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19312104
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:528744
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14331555
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21092247
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27533015
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:26502741
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16771924
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  4. XM_036159322.1XP_036015215.1  triple functional domain protein isoform X4

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (12) summary
    smart00150
    Location:11111211
    SPEC; Spectrin repeats
    cd11852
    Location:16271686
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25272585
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:37172
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19382111
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:535751
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14401562
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21162254
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27603022
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:26572748
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16831940
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
    cd00096
    Location:26652668
    Ig; Ig strand A' [structural motif]
  5. XM_030248467.1XP_030104327.1  triple functional domain protein isoform X6

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (11) summary
    smart00150
    Location:10841184
    SPEC; Spectrin repeats
    cd11852
    Location:16001659
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25002558
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:10145
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19112084
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:508724
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14131535
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:20892227
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27332995
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:26302721
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16571904
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  6. XM_006520052.4XP_006520115.1  triple functional domain protein isoform X3

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (11) summary
    smart00150
    Location:11181218
    SPEC; Spectrin repeats
    cd11852
    Location:16341693
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25342592
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:44179
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19452118
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:542758
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14471569
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21232261
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27673029
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:26642755
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:16911938
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  7. XM_006520050.5XP_006520113.1  triple functional domain protein isoform X1

    UniProtKB/Swiss-Prot
    Q0KL02, Q3U522, Q6P9K6, Q80W23
    Conserved Domains (11) summary
    smart00150
    Location:11421242
    SPEC; Spectrin repeats
    cd11852
    Location:16581717
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    cd11853
    Location:25582616
    SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:68203
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:19692142
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:566782
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14711593
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    cd13241
    Location:21472285
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    cd14113
    Location:27913053
    STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
    pfam07679
    Location:26882779
    I-set; Immunoglobulin I-set domain
    pfam16609
    Location:17151962
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region
  8. XM_006520054.5XP_006520117.1  triple functional domain protein isoform X8

    UniProtKB/TrEMBL
    A0A2I3BRP6
    Related
    ENSMUSP00000154653.2, ENSMUST00000227337.2
    Conserved Domains (7) summary
    smart00150
    Location:11431243
    SPEC; Spectrin repeats
    cd11852
    Location:16591718
    SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
    smart00516
    Location:69204
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:12951465
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:567783
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd13240
    Location:14721594
    PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
    pfam16609
    Location:17161889
    SH3-RhoG_link; SH3-RhoGEF linking unstructured region

RNA

  1. XR_004938814.1 RNA Sequence

  2. XR_004938815.1 RNA Sequence

  3. XR_001781509.3 RNA Sequence

  4. XR_001781508.3 RNA Sequence