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HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 [ Homo sapiens (human) ]

Gene ID: 220988, updated on 22-May-2022

Summary

Official Symbol
HNRNPA3provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein A3provided by HGNC
Primary source
HGNC:HGNC:24941
See related
Ensembl:ENSG00000170144 MIM:605372; AllianceGenome:HGNC:24941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBRNP; HNRPA3; D10S102; 2610510D13Rik
Summary
Enables RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 56.8), lymph node (RPKM 56.0) and 25 other tissues See more
Orthologs
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Genomic context

See HNRNPA3 in Genome Data Viewer
Location:
2q31.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (177212794..177223959)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (177695036..177706189)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178077522..178088687)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 40 Neighboring gene uncharacterized LOC105373759 Neighboring gene microRNA 4444-1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 5 Neighboring gene NFE2 like bZIP transcription factor 2 Neighboring gene microRNA 3128

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with HNRNPA3 is increased by RRE PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138232, MGC142030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein A3
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330247.2NP_001317176.1  heterogeneous nuclear ribonucleoprotein A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS82536.1
    UniProtKB/TrEMBL
    B4DDB6
    Related
    ENSP00000408487.1, ENST00000411529.6
    Conserved Domains (3) summary
    pfam11627
    Location:309325
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:1191
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  2. NM_001330248.2NP_001317177.1  heterogeneous nuclear ribonucleoprotein A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS82536.1
    UniProtKB/TrEMBL
    B4DDB6
    Related
    ENSP00000503186.1, ENST00000676874.1
    Conserved Domains (3) summary
    pfam11627
    Location:309325
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:1191
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  3. NM_001330249.2NP_001317178.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS2273.1
    UniProtKB/Swiss-Prot
    P51991
    Related
    ENSP00000504135.1, ENST00000678111.1
    Conserved Domains (3) summary
    pfam11627
    Location:331347
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  4. NM_001330250.2NP_001317179.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Related
    ENSP00000504649.1, ENST00000677043.1
    Conserved Domains (3) summary
    pfam11627
    Location:285300
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  5. NM_001330251.2NP_001317180.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Related
    ENSP00000503339.1, ENST00000676681.1
    Conserved Domains (3) summary
    pfam11627
    Location:285300
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  6. NM_001395170.1NP_001382099.1  heterogeneous nuclear ribonucleoprotein A3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Conserved Domains (2) summary
    smart00360
    Location:1484
    RRM; RNA recognition motif
    cl17169
    Location:105179
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_194247.4NP_919223.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_919223.1

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Consensus CDS
    CCDS2273.1
    UniProtKB/Swiss-Prot
    P51991
    Related
    ENSP00000376309.2, ENST00000392524.6
    Conserved Domains (3) summary
    pfam11627
    Location:331347
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

RNA

  1. NR_138470.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079305
    Related
    ENST00000483137.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    177212794..177223959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    177695036..177706189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)