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Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 [ Mus musculus (house mouse) ]

Gene ID: 229279, updated on 1-Mar-2024

Summary

Official Symbol
Hnrnpa3provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein A3provided by MGI
Primary source
MGI:MGI:1917171
See related
Ensembl:ENSMUSG00000059005 AllianceGenome:MGI:1917171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpa3; 2410013L13Rik; 2610209F03Rik; 2610510D13Rik
Summary
Predicted to enable RNA transmembrane transporter activity and mRNA binding activity. Predicted to be involved in mRNA transport. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in several cellular components, including neuron projection; nucleoplasm; and ribonucleoprotein granule. Predicted to be part of catalytic step 2 spliceosome and messenger ribonucleoprotein complex. Is expressed in central nervous system and sensory organ. Orthologous to human HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 167.7), liver E14 (RPKM 103.2) and 15 other tissues See more
Orthologs
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Genomic context

See Hnrnpa3 in Genome Data Viewer
Location:
2 C3; 2 44.75 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (75489416..75499751)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (75659105..75669407)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04864 Neighboring gene predicted gene, 39858 Neighboring gene predicted gene, 39859 Neighboring gene STARR-seq mESC enhancer starr_04867 Neighboring gene STARR-seq mESC enhancer starr_04869 Neighboring gene nuclear factor, erythroid derived 2, like 2 Neighboring gene RIKEN cDNA E030042O20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1590 Neighboring gene STARR-positive B cell enhancer ABC_E4469

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC37309, MGC101940, 2410013L13Rik, 2610209F03Rik, 2610510D13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of messenger ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein A3
Names
hnRNP A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359971.1NP_001346900.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL772404
    Consensus CDS
    CCDS50610.1
    UniProtKB/TrEMBL
    B2RXM2, Q0VG47
    Related
    ENSMUSP00000126069.3, ENSMUST00000164947.9
    Conserved Domains (3) summary
    pfam11627
    Location:310326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:1191
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  2. NM_053263.1NP_444493.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    See identical proteins and their annotated locations for NP_444493.1

    Status: VALIDATED

    Source sequence(s)
    AB201711, AF463524, AK011930, AK076236, BC038364, BC085474, CJ048391, CJ048901
    Consensus CDS
    CCDS50610.1
    UniProtKB/TrEMBL
    B2RXM2, Q0VG47
    Related
    ENSMUSP00000107593.2, ENSMUST00000111962.8
    Conserved Domains (3) summary
    pfam11627
    Location:310326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:1191
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  3. NM_146130.3NP_666242.2  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_666242.2

    Status: VALIDATED

    Source sequence(s)
    AK011930, AK076236, AK133860, BC038364, BC085474, CJ048391, CO045618
    Consensus CDS
    CCDS16149.1
    UniProtKB/Swiss-Prot
    Q8BG05, Q8BHF8
    UniProtKB/TrEMBL
    Q3UZG3, Q5FB19
    Related
    ENSMUSP00000107595.2, ENSMUST00000111964.8
    Conserved Domains (3) summary
    pfam11627
    Location:332348
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
  4. NM_198090.2NP_932758.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_932758.1

    Status: VALIDATED

    Source sequence(s)
    BC038364, CJ048391, CJ048901
    Consensus CDS
    CCDS16149.1
    UniProtKB/Swiss-Prot
    Q8BG05, Q8BHF8
    UniProtKB/TrEMBL
    Q3UZG3, Q5FB19
    Related
    ENSMUSP00000088298.5, ENSMUST00000090792.11
    Conserved Domains (3) summary
    pfam11627
    Location:332348
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    75489416..75499751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940316.1 RNA Sequence

  2. XR_866271.4 RNA Sequence