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Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 [ Mus musculus (house mouse) ]

Gene ID: 229279, updated on 2-Nov-2024

Summary

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Official Symbol
Hnrnpa3provided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein A3provided by MGI
Primary source
MGI:MGI:1917171
See related
Ensembl:ENSMUSG00000059005 AllianceGenome:MGI:1917171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpa3; 2410013L13Rik; 2610209F03Rik; 2610510D13Rik
Summary
Predicted to enable RNA transmembrane transporter activity and mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splicing, via spliceosome and mRNA transport. Predicted to be located in nucleus and ribonucleoprotein granule. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in central nervous system and sensory organ. Orthologous to human HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 167.7), liver E14 (RPKM 103.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnpa3 in Genome Data Viewer
Location:
2 C3; 2 44.75 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (75489416..75499751)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (75659105..75669407)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04864 Neighboring gene predicted gene, 39858 Neighboring gene predicted gene, 39859 Neighboring gene STARR-seq mESC enhancer starr_04867 Neighboring gene STARR-seq mESC enhancer starr_04869 Neighboring gene nuclear factor, erythroid derived 2, like 2 Neighboring gene RIKEN cDNA E030042O20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1590 Neighboring gene STARR-positive B cell enhancer ABC_E4469

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HnRNP A3 binds to and protects mammalian telomeric repeats in vitro. Tanaka E, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17502110
  2. Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals. Papadopoulou C, et al. Arch Biochem Biophys, 2012 Jul 15. PMID 22546510
  3. Heterogeneous nuclear ribonucleoprotein A3 is the liver nuclear protein binding to age related increase element RNA of the factor IX gene. Hamada T, et al. PLoS One, 2010 Sep 24. PMID 20885981, Free PMC Article
  4. RNF125 attenuates hepatocellular carcinoma progression by downregulating SRSF1-ERK pathway. Feng Z, et al. Oncogene, 2023 Jun. PMID 37142680
  5. HnRNP A3 genes and pseudogenes in the vertebrate genomes. Makeyev AV, et al. J Exp Zool A Comp Exp Biol, 2005 Apr 1. PMID 15776420

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.
    Title: Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.
  2. characterization of hnRNP A3 in human and mouse cell lines
    Title: Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals.
  3. hnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene.
    Title: Heterogeneous nuclear ribonucleoprotein A3 is the liver nuclear protein binding to age related increase element RNA of the factor IX gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37309, MGC101940, 2410013L13Rik, 2610209F03Rik, 2610510D13Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein A3
Names
hnRNP A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359971.1 → NP_001346900.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL772404
    Consensus CDS
    CCDS50610.1
    UniProtKB/TrEMBL
    B2RXM2, Q0VG47
    Related
    ENSMUSP00000126069.3, ENSMUST00000164947.9
    Conserved Domains (3) summary
    pfam11627
    Location:310 → 326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  2. NM_053263.1 → NP_444493.1  heterogeneous nuclear ribonucleoprotein A3 isoform c

    See identical proteins and their annotated locations for NP_444493.1

    Status: VALIDATED

    Source sequence(s)
    AB201711, AF463524, AK011930, AK076236, BC038364, BC085474, CJ048391, CJ048901
    Consensus CDS
    CCDS50610.1
    UniProtKB/TrEMBL
    B2RXM2, Q0VG47
    Related
    ENSMUSP00000107593.2, ENSMUST00000111962.8
    Conserved Domains (3) summary
    pfam11627
    Location:310 → 326
    HnRNPA1; Nuclear factor hnRNPA1
    cd12582
    Location:104 → 183
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    cd12763
    Location:11 → 91
    RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  3. NM_146130.3 → NP_666242.2  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_666242.2

    Status: VALIDATED

    Source sequence(s)
    AK011930, AK076236, AK133860, BC038364, BC085474, CJ048391, CO045618
    Consensus CDS
    CCDS16149.1
    UniProtKB/Swiss-Prot
    Q8BG05, Q8BHF8
    UniProtKB/TrEMBL
    Q3UZG3, Q5FB19
    Related
    ENSMUSP00000107595.2, ENSMUST00000111964.8
    Conserved Domains (3) summary
    pfam11627
    Location:332 → 348
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

  4. NM_198090.2 → NP_932758.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

    See identical proteins and their annotated locations for NP_932758.1

    Status: VALIDATED

    Source sequence(s)
    BC038364, CJ048391, CJ048901
    Consensus CDS
    CCDS16149.1
    UniProtKB/Swiss-Prot
    Q8BG05, Q8BHF8
    UniProtKB/TrEMBL
    Q3UZG3, Q5FB19
    Related
    ENSMUSP00000088298.5, ENSMUST00000090792.11
    Conserved Domains (3) summary
    pfam11627
    Location:332 → 348
    HnRNPA1; Nuclear factor hnRNPA1
    cd12578
    Location:36 → 113
    RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
    cd12582
    Location:126 → 205
    RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    75489416..75499751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940316.1 RNA Sequence

  2. XR_866271.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG05.1 GenPept UniProtKB/Swiss-Prot:Q8BG05

Gene LinkOut

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