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FCGR1A Fc fragment of IgG receptor Ia [ Homo sapiens (human) ]

Gene ID: 2209, updated on 8-Jul-2021

Summary

Official Symbol
FCGR1Aprovided by HGNC
Official Full Name
Fc fragment of IgG receptor Iaprovided by HGNC
Primary source
HGNC:HGNC:3613
See related
Ensembl:ENSG00000150337 MIM:146760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD64; FCRI; CD64A; IGFR1
Summary
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 19.0), placenta (RPKM 13.4) and 10 other tissues See more
Orthologs
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Genomic context

See FCGR1A in Genome Data Viewer
Location:
1q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (149782694..149800609)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149754250..149772165)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D4 (putative) pseudogene Neighboring gene tRNA-Arg (anticodon CCT) 8-1 Neighboring gene H2B clustered histone 18 Neighboring gene H3 clustered histone 13 Neighboring gene H4 clustered histone 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor I in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis, engulfment TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in early endosome membrane TAS
Traceable Author Statement
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity immunoglobulin gamma Fc receptor I
Names
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ia, receptor for (CD64)
Fc gamma receptor Ia
Fc-gamma RI
Fc-gamma receptor I A1
IgG Fc receptor I
fc-gamma RIA
fcgammaRIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007578.1 RefSeqGene

    Range
    4963..14787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_59

mRNA and Protein(s)

  1. NM_000566.4NP_000557.1  high affinity immunoglobulin gamma Fc receptor I isoform 2 precursor

    See identical proteins and their annotated locations for NP_000557.1

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Consensus CDS
    CCDS933.1
    UniProtKB/Swiss-Prot
    P12314
    Related
    ENSP00000358165.4, ENST00000369168.5
    Conserved Domains (3) summary
    cd05752
    Location:22100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104185
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    pfam00047
    Location:196274
    ig; Immunoglobulin domain
  2. NM_001378804.1NP_001365733.1  high affinity immunoglobulin gamma Fc receptor I isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:197275
    ig; Immunoglobulin domain
    cd05752
    Location:23101
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:105186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  3. NM_001378805.1NP_001365734.1  high affinity immunoglobulin gamma Fc receptor I isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:189267
    ig; Immunoglobulin domain
    cd05752
    Location:1593
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:97178
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  4. NM_001378806.1NP_001365735.1  high affinity immunoglobulin gamma Fc receptor I isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:196274
    ig; Immunoglobulin domain
    cd05752
    Location:22100
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:104185
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  5. NM_001378807.1NP_001365736.1  high affinity immunoglobulin gamma Fc receptor I isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:173251
    ig; Immunoglobulin domain
    cd05752
    Location:577
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
    cd05753
    Location:81162
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  6. NM_001378808.1NP_001365737.1  high affinity immunoglobulin gamma Fc receptor I isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (2) summary
    pfam00047
    Location:112190
    ig; Immunoglobulin domain
    cd05752
    Location:22100
    Ig1_FcgammaR_like; First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  7. NM_001378809.1NP_001365738.1  high affinity immunoglobulin gamma Fc receptor I isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:111189
    ig; Immunoglobulin domain
    cd00096
    Location:122128
    Ig; Ig strand B [structural motif]
    cd05753
    Location:19100
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  8. NM_001378810.1NP_001365739.1  high affinity immunoglobulin gamma Fc receptor I isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Related
    ENSP00000394279.1, ENST00000444948.5
    Conserved Domains (3) summary
    pfam00047
    Location:104182
    ig; Immunoglobulin domain
    cd00096
    Location:115121
    Ig; Ig strand B [structural motif]
    cd05753
    Location:1693
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains
  9. NM_001378811.1NP_001365740.1  high affinity immunoglobulin gamma Fc receptor I isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AC243772
    Conserved Domains (3) summary
    pfam00047
    Location:104182
    ig; Immunoglobulin domain
    cd00096
    Location:115121
    Ig; Ig strand B [structural motif]
    cd05753
    Location:1693
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

RNA

  1. NR_166121.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC243772
  2. NR_166122.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC243772
  3. NR_166123.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC243772

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    149782694..149800609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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