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Fcgr1 Fc receptor, IgG, high affinity I [ Mus musculus (house mouse) ]

Gene ID: 14129, updated on 8-Jan-2023

Summary

Official Symbol
Fcgr1provided by MGI
Official Full Name
Fc receptor, IgG, high affinity Iprovided by MGI
Primary source
MGI:MGI:95498
See related
Ensembl:ENSMUSG00000015947 AllianceGenome:MGI:95498
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD64; IGGHAFC; FcgammaRI
Summary
Enables IgG binding activity and IgG receptor activity. Acts upstream of or within several processes, including antibody-dependent cellular cytotoxicity; endocytosis; and positive regulation of hypersensitivity. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including FCGR1A (Fc gamma receptor Ia). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 4.7), liver E14 (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See Fcgr1 in Genome Data Viewer
Location:
3 F2.1; 3 41.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96190225..96201285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96282909..96293969, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene H3 clustered histone 13 Neighboring gene H2B clustered histone 18 Neighboring gene nuclear encoded tRNA asparagine 4 (anticodon GTT) Neighboring gene predicted gene, 24830

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables IgG binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables IgG receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables high-affinity IgG receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables leukotriene receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within antibody-dependent cellular cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis, recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of type III hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
high affinity immunoglobulin gamma Fc receptor I
Names
IgG high affinity Fc receptor
fc-gamma RI
fcRI
igG Fc receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010186.5NP_034316.1  high affinity immunoglobulin gamma Fc receptor I precursor

    See identical proteins and their annotated locations for NP_034316.1

    Status: PROVISIONAL

    Source sequence(s)
    AC093350
    Consensus CDS
    CCDS17639.1
    UniProtKB/Swiss-Prot
    P26151
    Related
    ENSMUSP00000029748.4, ENSMUST00000029748.8
    Conserved Domains (4) summary
    cd05752
    Location:32110
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:125194
    IG_like; Immunoglobulin like
    pfam00047
    Location:205283
    ig; Immunoglobulin domain
    cl11960
    Location:114194
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96190225..96201285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)