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PTK2B protein tyrosine kinase 2 beta [ Homo sapiens (human) ]

Gene ID: 2185, updated on 4-Nov-2018

Summary

Official Symbol
PTK2Bprovided by HGNC
Official Full Name
protein tyrosine kinase 2 betaprovided by HGNC
Primary source
HGNC:HGNC:9612
See related
Ensembl:ENSG00000120899 MIM:601212; Vega:OTTHUMG00000102082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 29.2), bone marrow (RPKM 29.0) and 24 other tissues See more
Orthologs

Genomic context

See PTK2B in Genome Data Viewer
Location:
8p21.2
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (27311482..27459391)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27168999..27316908)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene stathmin 4 Neighboring gene tripartite motif containing 35 Neighboring gene microRNA 6842 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit Neighboring gene epoxide hydrolase 2 Neighboring gene gulonolactone (L-) oxidase, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
NHGRI GWA Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV/tuberculosis coinfection upregulates PTK2B expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed
Knockdown of protein tyrosine kinase 2 beta (PTK2B) by siRNA enhances HIV-1 infectivity in Jurkat cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SMS2 is involved in HIV-1 gp120-induced phosphorylation and activation of PYK2 and polymerization of F-actin PubMed
env Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2 PubMed
env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
env HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1 PubMed
env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
env HIV-1 gp120-induced Pyk2 activation mediated by intracellular Ca2+ release is required for HIV-1 gp120-mediated Rac-1 activation and membrane fusion PubMed
Nef nef HIV-1 Nef expression in human T cells upregulates the levels of RAFTK activity through the SDF-1alpha signaling pathway PubMed
Tat tat HIV-1 Tat C induces phosphorylation of PTK2B in a dose-dependent manner in human brain microvascular endothelial cells PubMed
tat HIV-1 Tat stimulates the tyrosine phosphorylation of RAFTK and its association with paxillin, an effect mediated by the basic (amino acids 46-60) and RGD-containing (amino acids 65-80) domains of Tat and linked to AIDS-related Kaposi's sarcoma PubMed
reverse transcriptase gag-pol Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT PubMed
gag-pol HIV-1 RT is identified to have a physical interaction with protein tyrosine kinase 2 beta (PTK2B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
    Alpha-synuclein signaling, organism-specific biosystem
    Alpha-synuclein signaling
  • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
    Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    CXCR4-mediated signaling events, organism-specific biosystem
    CXCR4-mediated signaling events
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cell-Cell communication, organism-specific biosystem (from REACTOME)
    Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Coregulation of Androgen receptor activity, organism-specific biosystem
    Coregulation of Androgen receptor activity
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
    Endothelins, organism-specific biosystem
    Endothelins
  • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    FGF signaling pathway, organism-specific biosystem
    FGF signaling pathway
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
  • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 (IL-7) was discovered in the year 1988 as a factor that enhanced the growth of murine B-cell precursors in bone marrow culture system. It was also known as lymphopoietin 1and pre-B cell...
  • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL2-mediated signaling events, organism-specific biosystem
    IL2-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
    Integrins in angiogenesis, organism-specific biosystem
    Integrins in angiogenesis
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
    LPA receptor mediated events, organism-specific biosystem
    LPA receptor mediated events
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
  • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
    Osteopontin-mediated events, organism-specific biosystem
    Osteopontin-mediated events
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
    Signal regulatory protein (SIRP) family interactions, organism-specific biosystemSignal regulatory protein (SIRP)alpha, also known as SHPS-1 or SIRPA or CD172a, is a transmembrane protein expressed mostly on myeloid cells. CD47, a widely expressed transmembrane protein, is a liga...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
    Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
    Signaling of Hepatocyte Growth Factor Receptor
  • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-phosphoinositide-dependent protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to NMDA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
activation of Janus kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular defense response ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
 
ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
marginal zone B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of B cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inositol trisphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of release of sequestered calcium ion into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to hormone IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to osmotic stress IEA
Inferred from Electronic Annotation
more info
 
signal complex assembly IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
NMDA selective glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
apical dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein-tyrosine kinase 2-beta
Names
CAK-beta
FADK 2
PTK2B protein tyrosine kinase 2 beta
calcium-dependent tyrosine kinase
calcium-regulated non-receptor proline-rich tyrosine kinase
cell adhesion kinase beta
focal adhesion kinase 2
proline-rich tyrosine kinase 2
protein kinase B
related adhesion focal tyrosine kinase
NP_004094.3
NP_775266.1
NP_775267.1
NP_775268.1
XP_005273504.1
XP_005273505.1
XP_011542743.1
XP_011542744.1
XP_016868703.1
XP_016868704.1
XP_016868705.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029510.1 RefSeqGene

    Range
    5001..152910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004103.4NP_004094.3  protein-tyrosine kinase 2-beta isoform a

    See identical proteins and their annotated locations for NP_004094.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AF311103, AL120380, AW130888, BC036651, U33284, U43522
    Consensus CDS
    CCDS6057.1
    UniProtKB/Swiss-Prot
    Q14289
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  2. NM_173174.2NP_775266.1  protein-tyrosine kinase 2-beta isoform a

    See identical proteins and their annotated locations for NP_775266.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AC124649, AL120380, AW130888, BC036651, BM712234, BQ009032, U33284
    Consensus CDS
    CCDS6057.1
    UniProtKB/Swiss-Prot
    Q14289
    Related
    ENSP00000380638.1, OTTHUMP00000128275, ENST00000397501.5, OTTHUMT00000219916
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  3. NM_173175.2NP_775267.1  protein-tyrosine kinase 2-beta isoform b

    See identical proteins and their annotated locations for NP_775267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AF311103, AL120380, AW130888, BC036651, U33284
    Consensus CDS
    CCDS6058.1
    UniProtKB/Swiss-Prot
    Q14289
    Related
    ENSP00000391995.2, ENST00000420218.3
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:830959
    Focal_AT; Focal adhesion targeting region
  4. NM_173176.2NP_775268.1  protein-tyrosine kinase 2-beta isoform a

    See identical proteins and their annotated locations for NP_775268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
    Source sequence(s)
    AF311103, AL120380, AW130888, BC042599, DA773624, U33284
    Consensus CDS
    CCDS6057.1
    UniProtKB/Swiss-Prot
    Q14289
    Related
    ENSP00000332816.6, OTTHUMP00000225229, ENST00000346049.9, OTTHUMT00000376116
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    27311482..27459391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013214.1XP_016868703.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/Swiss-Prot
    Q14289
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  2. XM_005273448.5XP_005273505.1  protein-tyrosine kinase 2-beta isoform X2

    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:860989
    Focal_AT; Focal adhesion targeting region
  3. XM_011544442.3XP_011542744.1  protein-tyrosine kinase 2-beta isoform X3

    Conserved Domains (6) summary
    cd05056
    Location:405674
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:412666
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261355
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:859988
    Focal_AT; Focal adhesion targeting region
  4. XM_017013216.2XP_016868705.1  protein-tyrosine kinase 2-beta isoform X4

  5. XM_011544441.2XP_011542743.1  protein-tyrosine kinase 2-beta isoform X1

    See identical proteins and their annotated locations for XP_011542743.1

    UniProtKB/Swiss-Prot
    Q14289
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  6. XM_017013215.1XP_016868704.1  protein-tyrosine kinase 2-beta isoform X3

    Conserved Domains (6) summary
    cd05056
    Location:405674
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:412666
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261355
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:859988
    Focal_AT; Focal adhesion targeting region
  7. XM_005273447.4XP_005273504.1  protein-tyrosine kinase 2-beta isoform X1

    See identical proteins and their annotated locations for XP_005273504.1

    UniProtKB/Swiss-Prot
    Q14289
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
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