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Ptk2b PTK2 protein tyrosine kinase 2 beta [ Mus musculus (house mouse) ]

Gene ID: 19229, updated on 18-Sep-2018

Summary

Official Symbol
Ptk2bprovided by MGI
Official Full Name
PTK2 protein tyrosine kinase 2 betaprovided by MGI
Primary source
MGI:MGI:104908
See related
Ensembl:ENSMUSG00000059456 Vega:OTTMUSG00000016348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAKB; FAK2; PYK2; CADTK; FADK2; Raftk; CAKbeta; E430023O05Rik
Expression
Broad expression in frontal lobe adult (RPKM 53.4), cortex adult (RPKM 51.8) and 21 other tissues See more
Orthologs

Genomic context

See Ptk2b in Genome Data Viewer
Location:
14 D1; 14 34.36 cM
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (66153257..66281068, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (66772094..66899889, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 2, cytoplasmic Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) Neighboring gene RIKEN cDNA 1700001G11 gene Neighboring gene tripartite motif-containing 35 Neighboring gene predicted gene, 41183

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-phosphoinositide-dependent protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to NMDA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
actin filament organization ISO
Inferred from Sequence Orthology
more info
 
activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular defense response ISO
Inferred from Sequence Orthology
more info
 
cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
chemokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
marginal zone B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of NMDA receptor activity ISO
Inferred from Sequence Orthology
more info
 
regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of inositol trisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
signal complex assembly IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NMDA selective glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
apical dendrite ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynapse ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein-tyrosine kinase 2-beta
Names
CAK-beta
calcium-dependent tyrosine kinase
calcium-regulated non-receptor proline-rich tyrosine kinase
cell adhesion kinase beta
cellular adhesion kinase beta
focal adhesion kinase 2
proline-rich tyrosine kinase 2
related adhesion focal tyrosine kinase
NP_001155837.1
NP_001155838.1
NP_766086.2
XP_006518789.1
XP_011243296.1
XP_017171415.1
XP_017171416.1
XP_017171417.1
XP_017171418.1
XP_017171419.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162365.1NP_001155837.1  protein-tyrosine kinase 2-beta isoform 2

    See identical proteins and their annotated locations for NP_001155837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC140329, AK150105, BY204086, CD775714
    Consensus CDS
    CCDS49525.1
    UniProtKB/TrEMBL
    Q3UDE9
    Related
    ENSMUSP00000106750.1, OTTMUSP00000021824, ENSMUST00000111121.1, OTTMUST00000047906
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:868997
    Focal_AT; Focal adhesion targeting region
  2. NM_001162366.2NP_001155838.1  protein-tyrosine kinase 2-beta isoform 1

    See identical proteins and their annotated locations for NP_001155838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC140329, AI181574, AK150105, BY203814, BY206153, CD775714
    Consensus CDS
    CCDS49526.1
    UniProtKB/Swiss-Prot
    Q9QVP9
    UniProtKB/TrEMBL
    K7QD41, Q3UDE9
    Related
    ENSMUSP00000137008.1, ENSMUST00000178730.7
    Conserved Domains (4) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  3. NM_001360233.1NP_001347162.1  protein-tyrosine kinase 2-beta isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC140329, AI181574, AK150105, BY203814, CD775714
    Conserved Domains (4) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  4. NM_172498.3NP_766086.2  protein-tyrosine kinase 2-beta isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
    Source sequence(s)
    AA462640, AC140329, AK150105, BY204086, CD775714
    Consensus CDS
    CCDS27220.1
    UniProtKB/TrEMBL
    E9Q2A6, Q3UDE9
    Related
    ENSMUSP00000086661.2, OTTMUSP00000017564, ENSMUST00000089250.8, OTTMUST00000039302
    Conserved Domains (6) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00219
    Location:425679
    TyrKc; Tyrosine kinase, catalytic domain
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    cd14473
    Location:150254
    FERM_B-lobe; FERM domain B-lobe
    pfam03623
    Location:830959
    Focal_AT; Focal adhesion targeting region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    66153257..66281068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315930.1XP_017171419.1  protein-tyrosine kinase 2-beta isoform X3

  2. XM_017315926.1XP_017171415.1  protein-tyrosine kinase 2-beta isoform X1

  3. XM_006518726.3XP_006518789.1  protein-tyrosine kinase 2-beta isoform X2

    UniProtKB/Swiss-Prot
    Q9QVP9
    UniProtKB/TrEMBL
    K7QD41
    Related
    ENSMUSP00000022622.7, OTTMUSP00000017565, ENSMUST00000022622.13, OTTMUST00000039303
    Conserved Domains (4) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  4. XM_017315929.1XP_017171418.1  protein-tyrosine kinase 2-beta isoform X1

  5. XM_017315927.1XP_017171416.1  protein-tyrosine kinase 2-beta isoform X1

  6. XM_011244994.2XP_011243296.1  protein-tyrosine kinase 2-beta isoform X2

    UniProtKB/Swiss-Prot
    Q9QVP9
    UniProtKB/TrEMBL
    K7QD41
    Conserved Domains (4) summary
    cd05056
    Location:418687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41254
    B41; Band 4.1 homologues
    cd13190
    Location:261368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:8721001
    Focal_AT; Focal adhesion targeting region
  7. XM_017315928.1XP_017171417.1  protein-tyrosine kinase 2-beta isoform X1

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