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ETS2 ETS proto-oncogene 2, transcription factor [ Homo sapiens (human) ]

Gene ID: 2114, updated on 2-Mar-2021

Summary

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Official Symbol
ETS2provided by HGNC
Official Full Name
ETS proto-oncogene 2, transcription factorprovided by HGNC
Primary source
HGNC:HGNC:3489
See related
Ensembl:ENSG00000157557 MIM:164740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETS2IT1
Summary
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues See more
Orthologs
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Genomic context

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See ETS2 in Genome Data Viewer
Location:
21q22.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (38805183..38824955)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40177107..40196879)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 114 Neighboring gene uncharacterized LOC107985480 Neighboring gene uncharacterized LOC101928398 Neighboring gene uncharacterized LOC400867 Neighboring gene ribosomal protein SA pseudogene 64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High ETS2 expression predicts poor prognosis in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation. Zhang G, et al. Ann Hematol, 2019 Feb. PMID 30022221
  2. Down-regulation of ETS2 inhibits the invasion and metastasis of renal cell carcinoma cells by inducing EMT via the PI3K/Akt signaling pathway. Zhang GW, et al. Biomed Pharmacother, 2018 Aug. PMID 29772431
  3. ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63. Torres A, et al. Prostate, 2018 Sep. PMID 29761525, Free PMC Article
  4. E26 Transformation-Specific Transcription Factor ETS2 as an Oncogene Promotes the Progression of Hypopharyngeal Cancer. Liu X, et al. Cancer Biother Radiopharm, 2017 Nov. PMID 29111780
  5. High expression of ETS2 predicts poor prognosis in acute myeloid leukemia and may guide treatment decisions. Fu L, et al. J Transl Med, 2017 Jul 19. PMID 28724426, Free PMC Article

See all (131) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DeltaNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma.
    Title: ΔNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma.
  2. RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer.
    Title: RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer.
  3. Exosomal miR-663b targets Ets2-repressor factor to promote proliferation and the epithelial-mesenchymal transition of bladder cancer cells.
    Title: Exosomal miR-663b targets Ets2-repressor factor to promote proliferation and the epithelial-mesenchymal transition of bladder cancer cells.
  4. Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model.
    Title: Association of Cyclin Dependent Kinase 10 and Transcription Factor 2 during Human Corneal Epithelial Wound Healing in vitro model.
  5. ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription.
    Title: ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription.
  6. Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages.
    Title: Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages.
  7. ETS2 is highly expressed in p63-expressing prostatic carcinomas and benign prostate basal cells, with lower expression in luminal cells and primary usual-type adenocarcinomas.
    Title: ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63.
  8. High ETS2 expression predicts poor prognosis in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.
    Title: High ETS2 expression predicts poor prognosis in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.
  9. ETS2 is of potential value as a molecular target for RCC treatment.
    Title: Down-regulation of ETS2 inhibits the invasion and metastasis of renal cell carcinoma cells by inducing EMT via the PI3K/Akt signaling pathway.
  10. ETS2 functions as an oncogene and plays a key role in the progression of hypopharyngeal cancer.
    Title: E26 Transformation-Specific Transcription Factor ETS2 as an Oncogene Promotes the Progression of Hypopharyngeal Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (79)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of v-ets erythroblastosis virus E26 oncogene homolog 2 (avian, ETS2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
 PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
chromatin ISA
Inferred from Sequence Alignment
more info
  
cytosol IDA
Inferred from Direct Assay
more info
  
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleoplasm TAS
Traceable Author Statement
more info
  
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein C-ets-2
Names
oncogene ETS-2
v-ets avian erythroblastosis virus E2 oncogene homolog 2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
v-ets erythroblastosis virus E26 oncogene homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256295.2 → NP_001243224.1  protein C-ets-2 isoform 2

    See identical proteins and their annotated locations for NP_001243224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK000535, AK096841, AP001040, AP001041
    Conserved Domains (3) summary
    cd08543
    Location:225 → 313
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:502 → 586
    ETS; erythroblast transformation specific domain
    pfam05350
    Location:39 → 143
    GSK-3_bind; Glycogen synthase kinase-3 binding

  2. NM_005239.6 → NP_005230.1  protein C-ets-2 isoform 1

    See identical proteins and their annotated locations for NP_005230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AA452482, AK000535, BC042954, J04102
    Consensus CDS
    CCDS13659.1
    UniProtKB/Swiss-Prot
    P15036
    Related
    ENSP00000354194.3, ENST00000360938.8
    Conserved Domains (2) summary
    cd08543
    Location:85 → 173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362 → 446
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    38805183..38824955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260935.1 → XP_005260992.1  protein C-ets-2 isoform X1

    See identical proteins and their annotated locations for XP_005260992.1

    UniProtKB/Swiss-Prot
    P15036
    Conserved Domains (2) summary
    cd08543
    Location:85 → 173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362 → 446
    ETS; erythroblast transformation specific domain

  2. XM_017028290.1 → XP_016883779.1  protein C-ets-2 isoform X1

    UniProtKB/Swiss-Prot
    P15036
    Conserved Domains (2) summary
    cd08543
    Location:85 → 173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362 → 446
    ETS; erythroblast transformation specific domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15036.1 GenPept UniProtKB/Swiss-Prot:P15036

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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