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ETS2 ETS proto-oncogene 2, transcription factor [ Homo sapiens (human) ]

Gene ID: 2114, updated on 2-Mar-2021

Summary

Official Symbol
ETS2provided by HGNC
Official Full Name
ETS proto-oncogene 2, transcription factorprovided by HGNC
Primary source
HGNC:HGNC:3489
See related
Ensembl:ENSG00000157557 MIM:164740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETS2IT1
Summary
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues See more
Orthologs
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Genomic context

See ETS2 in Genome Data Viewer
Location:
21q22.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (38805183..38824955)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40177107..40196879)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 114 Neighboring gene uncharacterized LOC107985480 Neighboring gene uncharacterized LOC101928398 Neighboring gene uncharacterized LOC400867 Neighboring gene ribosomal protein SA pseudogene 64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of v-ets erythroblastosis virus E26 oncogene homolog 2 (avian, ETS2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chromatin ISA
Inferred from Sequence Alignment
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein C-ets-2
Names
oncogene ETS-2
v-ets avian erythroblastosis virus E2 oncogene homolog 2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
v-ets erythroblastosis virus E26 oncogene homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256295.2NP_001243224.1  protein C-ets-2 isoform 2

    See identical proteins and their annotated locations for NP_001243224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK000535, AK096841, AP001040, AP001041
    Conserved Domains (3) summary
    cd08543
    Location:225313
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:502586
    ETS; erythroblast transformation specific domain
    pfam05350
    Location:39143
    GSK-3_bind; Glycogen synthase kinase-3 binding
  2. NM_005239.6NP_005230.1  protein C-ets-2 isoform 1

    See identical proteins and their annotated locations for NP_005230.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AA452482, AK000535, BC042954, J04102
    Consensus CDS
    CCDS13659.1
    UniProtKB/Swiss-Prot
    P15036
    Related
    ENSP00000354194.3, ENST00000360938.8
    Conserved Domains (2) summary
    cd08543
    Location:85173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362446
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    38805183..38824955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260935.1XP_005260992.1  protein C-ets-2 isoform X1

    See identical proteins and their annotated locations for XP_005260992.1

    UniProtKB/Swiss-Prot
    P15036
    Conserved Domains (2) summary
    cd08543
    Location:85173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362446
    ETS; erythroblast transformation specific domain
  2. XM_017028290.1XP_016883779.1  protein C-ets-2 isoform X1

    UniProtKB/Swiss-Prot
    P15036
    Conserved Domains (2) summary
    cd08543
    Location:85173
    SAM_PNT-ETS-2; Sterile alpha motif (SAM)/Pointed domain of ETS-2
    smart00413
    Location:362446
    ETS; erythroblast transformation specific domain
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