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Zfp143 zinc finger protein 143 [ Mus musculus (house mouse) ]

Gene ID: 20841, updated on 23-Jul-2026
Official Symbol
Zfp143provided by MGI
Official Full Name
zinc finger protein 143provided by MGI
Primary source
MGI:MGI:1277969
See related
Ensembl:ENSMUSG00000061079 AllianceGenome:MGI:1277969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SBF; Staf; Zfp79; pHZ-1; KRAB14; Znf143; Zfp80-rs1; D7Ertd805e
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of smooth muscle cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Predicted to be active in chromatin. Is expressed in central nervous system; early conceptus; genitourinary system; and pancreas. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
all
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See Zfp143 in Genome Data Viewer
Location:
7 E3; 7 57.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109660898..109694603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110061689..110095396)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25636 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway. Dong Y, et al. Epigenetics, 2023 Dec. PMID 37566742, Free PMC Article
  2. The evolutionary conservation of the bidirectional activity of the NWC gene promoter in jawed vertebrates and the domestication of the RAG transposon. Sniezewski L, et al. Dev Comp Immunol, 2018 Apr. PMID 29175053
  3. Molecular cloning and characterization of the murine staf cDNA encoding a transcription activating factor for the selenocysteine tRNA gene in mouse mammary gland. Adachi K, et al. J Biol Chem, 1998 Apr 10. PMID 9535833
  4. Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function. Narducci DN, et al. Mol Cell, 2025 Jan 2. PMID 39708803, Free PMC Article
  5. Zinc Finger Protein 143 Promotes Endometriotic Lesion Growth and Fibrosis through the Plasminogen Activator Inhibitor-1 Pathway. Zhang K, et al. Am J Pathol, 2026 Jun 18. PMID 42314926

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.
    Title: ZNF143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased lncRNA NEAT1 expression to activate ROCK2 pathway.
  2. ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
    Title: ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
  3. Zfp143 regulates Nanog expression through modulation of Oct4 binding.
    Title: Zfp143 regulates Nanog through modulation of Oct4 binding.
  4. STAF influences selenoprotein expression by enhancing Sec tRNA gene synthesis in an organ-specific manner
    Title: The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables chromatin loop anchoring activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription regulator activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in chromatin looping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome EXP
Inferred from Experiment
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
zinc finger protein 143
Names
mStaf
selenocysteine tRNA gene transcription-activating factor
zfp-143
zinc finger protein 80, related sequence 1
NP_001361547.1
NP_001392700.1
NP_001392701.1
NP_033307.2
XP_036008747.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374618.1 → NP_001361547.1  zinc finger protein 143 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    Consensus CDS
    CCDS90307.1
    UniProtKB/Swiss-Prot
    O70230, Q8BGB0, Q8CEI6, Q8CI27
    Related
    ENSMUSP00000081778.5, ENSMUST00000084727.11
    Conserved Domains (3) summary
    COG5048
    Location:251 → 424
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:239 → 261
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001405771.1 → NP_001392700.1  zinc finger protein 143 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    UniProtKB/Swiss-Prot
    O70230, Q8BGB0, Q8CEI6, Q8CI27

  3. NM_001405772.1 → NP_001392701.1  zinc finger protein 143 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244

  4. NM_009281.4 → NP_033307.2  zinc finger protein 143 isoform 2

    See identical proteins and their annotated locations for NP_033307.2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    Consensus CDS
    CCDS57580.1
    UniProtKB/Swiss-Prot
    O70230
    Related
    ENSMUSP00000148235.2, ENSMUST00000211798.2
    Conserved Domains (3) summary
    COG5048
    Location:250 → 423
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:206 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:238 → 260
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109660898..109694603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152854.1 → XP_036008747.1  zinc finger protein 143 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:48 → 221
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:4 → 89
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:36 → 58
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70230.2 GenPept UniProtKB/Swiss-Prot:O70230

Gene LinkOut

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