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Zfp143 zinc finger protein 143 [ Mus musculus (house mouse) ]

Gene ID: 20841, updated on 5-Mar-2024

Summary

Official Symbol
Zfp143provided by MGI
Official Full Name
zinc finger protein 143provided by MGI
Primary source
MGI:MGI:1277969
See related
Ensembl:ENSMUSG00000061079 AllianceGenome:MGI:1277969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SBF; Staf; Zfp79; pHZ-1; KRAB14; Znf143; Zfp80-rs1; D7Ertd805e
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of smooth muscle cell proliferation and positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Zfp143 in Genome Data Viewer
Location:
7 E3; 7 57.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109660898..109694603)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110061689..110095396)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25636 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of PcG protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein 143
Names
mStaf
selenocysteine tRNA gene transcription-activating factor
zfp-143
zinc finger protein 80, related sequence 1
NP_001361547.1
NP_001392700.1
NP_001392701.1
NP_033307.2
XP_036008747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374618.1NP_001361547.1  zinc finger protein 143 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    Consensus CDS
    CCDS90307.1
    UniProtKB/Swiss-Prot
    O70230, Q8BGB0, Q8CEI6, Q8CI27
    Related
    ENSMUSP00000081778.5, ENSMUST00000084727.11
    Conserved Domains (3) summary
    COG5048
    Location:251424
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001405771.1NP_001392700.1  zinc finger protein 143 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    UniProtKB/Swiss-Prot
    O70230, Q8BGB0, Q8CEI6, Q8CI27
  3. NM_001405772.1NP_001392701.1  zinc finger protein 143 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
  4. NM_009281.4NP_033307.2  zinc finger protein 143 isoform 2

    See identical proteins and their annotated locations for NP_033307.2

    Status: VALIDATED

    Source sequence(s)
    AC121995, AC147244
    Consensus CDS
    CCDS57580.1
    UniProtKB/Swiss-Prot
    O70230
    Related
    ENSMUSP00000148235.2, ENSMUST00000211798.2
    Conserved Domains (3) summary
    COG5048
    Location:250423
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:206291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    109660898..109694603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152854.1XP_036008747.1  zinc finger protein 143 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:48221
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:489
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:3658
    ZF_C2H2; C2H2 Zn finger [structural motif]