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ZNF143 zinc finger protein 143 [ Homo sapiens (human) ]

Gene ID: 7702, updated on 5-Apr-2020

Summary

Official Symbol
ZNF143provided by HGNC
Official Full Name
zinc finger protein 143provided by HGNC
Primary source
HGNC:HGNC:12928
See related
Ensembl:ENSG00000166478 MIM:603433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBF; STAF; pHZ-1
Expression
Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF143 in Genome Data Viewer
Location:
11p15.4
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (9460965..9528524)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9482512..9550071)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene uncharacterized LOC644656 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1006 Neighboring gene WEE1 G2 checkpoint kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 143
Names
SPH-binding factor
hStaf
selenocysteine tRNA gene transcription-activating factor
transcriptional activator Staf
NP_001269585.1
NP_001269586.1
NP_003433.3
XP_005253178.1
XP_005253179.1
XP_005253184.1
XP_011518651.1
XP_016873741.1
XP_016873742.1
XP_016873743.1
XP_016873744.1
XP_016873745.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282656.1NP_001269585.1  zinc finger protein 143 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AK297214, AK313330, BF515092, BG825506, CN295530
    Consensus CDS
    CCDS60720.1
    UniProtKB/Swiss-Prot
    P52747
    Related
    ENSP00000432154.1, ENST00000530463.5
    Conserved Domains (4) summary
    COG5048
    Location:263321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298413
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_001282657.1NP_001269586.1  zinc finger protein 143 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK297214, BC014458, BF515092, BG825506, CN295530
    Consensus CDS
    CCDS60721.1
    UniProtKB/Swiss-Prot
    P52747
    Related
    ENSP00000379843.3, ENST00000396597.7
    Conserved Domains (5) summary
    COG5048
    Location:233291
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:208230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:282309
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:268383
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:51161
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  3. NM_003442.6NP_003433.3  zinc finger protein 143 isoform 1

    See identical proteins and their annotated locations for NP_003433.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK297214, AW162015, BC020219, BG825506
    Consensus CDS
    CCDS7799.2
    UniProtKB/Swiss-Prot
    P52747
    Related
    ENSP00000379847.2, ENST00000396602.7
    Conserved Domains (5) summary
    COG5048
    Location:264322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313340
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:299414
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:82192
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    9460965..9528524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018256.1XP_016873745.1  zinc finger protein 143 isoform X7

  2. XM_017018252.1XP_016873741.1  zinc finger protein 143 isoform X3

  3. XM_017018253.1XP_016873742.1  zinc finger protein 143 isoform X4

  4. XM_005253122.1XP_005253179.1  zinc finger protein 143 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:278336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:253275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:327354
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:313428
    zf-C2H2_8; C2H2-type zinc ribbon
  5. XM_005253127.1XP_005253184.1  zinc finger protein 143 isoform X8

    Conserved Domains (4) summary
    COG5048
    Location:61119
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:3658
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:110137
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:96211
    zf-C2H2_8; C2H2-type zinc ribbon
  6. XM_005253121.1XP_005253178.1  zinc finger protein 143 isoform X1

    Conserved Domains (5) summary
    COG5048
    Location:279337
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254276
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328355
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:314429
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:97207
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  7. XM_011520349.2XP_011518651.1  zinc finger protein 143 isoform X5

    See identical proteins and their annotated locations for XP_011518651.1

    UniProtKB/Swiss-Prot
    P52747
    Conserved Domains (5) summary
    COG5048
    Location:264322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:313340
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:299414
    zf-C2H2_8; C2H2-type zinc ribbon
    cl00342
    Location:82192
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  8. XM_017018254.2XP_016873743.1  zinc finger protein 143 isoform X6

    UniProtKB/Swiss-Prot
    P52747
    Conserved Domains (4) summary
    COG5048
    Location:263321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298413
    zf-C2H2_8; C2H2-type zinc ribbon
  9. XM_017018255.1XP_016873744.1  zinc finger protein 143 isoform X6

    UniProtKB/Swiss-Prot
    P52747
    Conserved Domains (4) summary
    COG5048
    Location:263321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:312339
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:298413
    zf-C2H2_8; C2H2-type zinc ribbon
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