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ZBTB7C zinc finger and BTB domain containing 7C [ Homo sapiens (human) ]

Gene ID: 201501, updated on 4-Jun-2020

Summary

Official Symbol
ZBTB7Cprovided by HGNC
Official Full Name
zinc finger and BTB domain containing 7Cprovided by HGNC
Primary source
HGNC:HGNC:31700
See related
Ensembl:ENSG00000184828 MIM:616591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APM1; APM-1; ZBTB36; ZNF857C
Expression
Broad expression in esophagus (RPKM 8.6), skin (RPKM 4.3) and 18 other tissues See more
Orthologs

Genomic context

See ZBTB7C in Genome Data Viewer
Location:
18q21.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (48026672..48412639, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (45553043..45935793, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene SMAD family member 2 Neighboring gene MT-CO2 pseudogene 2 Neighboring gene uncharacterized LOC105372101 Neighboring gene uncharacterized LOC105372104 Neighboring gene RNA, U6 small nuclear 708, pseudogene Neighboring gene chromosome 18 open reading frame 12 Neighboring gene Sharpr-MPRA regulatory region 5458 Neighboring gene RNA, 5S ribosomal pseudogene 456

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
NHGRI GWA Catalog
Genome-wide association study in Han Chinese identifies three novel loci for human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7C
Names
B230208J24Rik
affected by papillomavirus DNA integration in ME180 cells protein 1
zinc finger and BTB domain containing 36
zinc finger and BTB domain-containing protein 36
zinc finger protein 857C

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039360.3NP_001034449.1  zinc finger and BTB domain-containing protein 7C

    See identical proteins and their annotated locations for NP_001034449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC105042, AM988836, CD366839, EF120357
    Consensus CDS
    CCDS32830.1
    UniProtKB/Swiss-Prot
    A1YPR0
    UniProtKB/TrEMBL
    B2RG49
    Related
    ENSP00000439781.1, ENST00000535628.6
    Conserved Domains (4) summary
    smart00225
    Location:35128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24127
    BTB; BTB/POZ domain
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001318841.2NP_001305770.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC105042, AM988839, BM983365
    Consensus CDS
    CCDS32830.1
    UniProtKB/Swiss-Prot
    A1YPR0
    UniProtKB/TrEMBL
    B2RG49
    Related
    ENSP00000467877.1, ENST00000590800.6
    Conserved Domains (4) summary
    smart00225
    Location:35128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24127
    BTB; BTB/POZ domain
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001371284.1NP_001358213.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC105042, AM988839, AM991966
  4. NM_001371285.1NP_001358214.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC105042, AM988839, AM991284
    Related
    ENSP00000468782.1, ENST00000588982.5
  5. NM_001371286.1NP_001358215.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC024288, AC105042, AM988839, AM991285
  6. NM_001371287.1NP_001358216.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC024288, AC105042, AM988839, AM989328, AM991966
  7. NM_001371288.1NP_001358217.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC091150, AC105042, AM988839, AM991277
  8. NM_001371290.1NP_001358219.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC024288, AC105042, AM988839, AM989330, AM991970
  9. NM_001371291.1NP_001358220.1  zinc finger and BTB domain-containing protein 7C

    Status: VALIDATED

    Source sequence(s)
    AC024288, AC105042, AM988839, AM989330, AM991969

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    48026672..48412639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025605.1XP_016881094.1  zinc finger and BTB domain-containing protein 7C isoform X1

    Conserved Domains (4) summary
    smart00225
    Location:84177
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:73176
    BTB; BTB/POZ domain
    pfam13465
    Location:483508
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005258229.4XP_005258286.1  zinc finger and BTB domain-containing protein 7C isoform X4

    See identical proteins and their annotated locations for XP_005258286.1

    UniProtKB/Swiss-Prot
    A1YPR0
    UniProtKB/TrEMBL
    B2RG49
    Conserved Domains (4) summary
    smart00225
    Location:35128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24127
    BTB; BTB/POZ domain
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011525864.2XP_011524166.1  zinc finger and BTB domain-containing protein 7C isoform X2

    See identical proteins and their annotated locations for XP_011524166.1

    Conserved Domains (4) summary
    smart00225
    Location:44137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:403423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:33136
    BTB; BTB/POZ domain
    pfam13465
    Location:443468
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017025607.1XP_016881096.1  zinc finger and BTB domain-containing protein 7C isoform X2

    Conserved Domains (4) summary
    smart00225
    Location:44137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:403423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:33136
    BTB; BTB/POZ domain
    pfam13465
    Location:443468
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011525865.3XP_011524167.1  zinc finger and BTB domain-containing protein 7C isoform X2

    See identical proteins and their annotated locations for XP_011524167.1

    Conserved Domains (4) summary
    smart00225
    Location:44137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:403423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:33136
    BTB; BTB/POZ domain
    pfam13465
    Location:443468
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011525863.3XP_011524165.1  zinc finger and BTB domain-containing protein 7C isoform X2

    See identical proteins and their annotated locations for XP_011524165.1

    Conserved Domains (4) summary
    smart00225
    Location:44137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:403423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:33136
    BTB; BTB/POZ domain
    pfam13465
    Location:443468
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011525869.3XP_011524171.1  zinc finger and BTB domain-containing protein 7C isoform X3

    Conserved Domains (4) summary
    smart00225
    Location:43136
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:402422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:32135
    BTB; BTB/POZ domain
    pfam13465
    Location:442467
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017025606.2XP_016881095.1  zinc finger and BTB domain-containing protein 7C isoform X2

    Conserved Domains (4) summary
    smart00225
    Location:44137
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:403423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:33136
    BTB; BTB/POZ domain
    pfam13465
    Location:443468
    zf-H2C2_2; Zinc-finger double domain
  9. XM_017025609.2XP_016881098.1  zinc finger and BTB domain-containing protein 7C isoform X4

    UniProtKB/Swiss-Prot
    A1YPR0
    UniProtKB/TrEMBL
    B2RG49
    Conserved Domains (4) summary
    smart00225
    Location:35128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24127
    BTB; BTB/POZ domain
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011525871.2XP_011524173.1  zinc finger and BTB domain-containing protein 7C isoform X4

    See identical proteins and their annotated locations for XP_011524173.1

    UniProtKB/Swiss-Prot
    A1YPR0
    UniProtKB/TrEMBL
    B2RG49
    Conserved Domains (4) summary
    smart00225
    Location:35128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:394414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24127
    BTB; BTB/POZ domain
    pfam13465
    Location:434459
    zf-H2C2_2; Zinc-finger double domain
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