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EIF4B eukaryotic translation initiation factor 4B [ Homo sapiens (human) ]

Gene ID: 1975, updated on 5-Jul-2020

Summary

Official Symbol
EIF4Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 4Bprovided by HGNC
Primary source
HGNC:HGNC:3285
See related
Ensembl:ENSG00000063046 MIM:603928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF-4B; PRO1843
Expression
Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues See more
Orthologs

Genomic context

See EIF4B in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53006456..53042215)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53399942..53435993)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microRNA 9898 Neighboring gene keratin 8 Neighboring gene KRT18 locus control region Neighboring gene keratin 18 Neighboring gene uncharacterized LOC283335 Neighboring gene tensin 2 Neighboring gene microRNA 6757

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 4B (EIF4B) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA strand annealing activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA strand annealing activity IEA
Inferred from Electronic Annotation
more info
 
RNA strand-exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 4F complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eukaryotic translation initiation factor 4F complex assembly IEA
Inferred from Electronic Annotation
more info
 
formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300821.3NP_001287750.1  eukaryotic translation initiation factor 4B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068888
    Consensus CDS
    CCDS73474.1
    UniProtKB/TrEMBL
    B4DRM3, E7EX17, Q7Z5Y0
    Related
    ENSP00000388806.3, ENST00000420463.7
    Conserved Domains (2) summary
    COG0724
    Location:83190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:95171
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
  2. NM_001330654.2NP_001317583.1  eukaryotic translation initiation factor 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068888
    Consensus CDS
    CCDS86303.1
    UniProtKB/Swiss-Prot
    P23588
    Related
    ENSP00000412530.3, ENST00000416762.7
  3. NM_001417.7NP_001408.2  eukaryotic translation initiation factor 4B isoform 2

    See identical proteins and their annotated locations for NP_001408.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC068888
    Consensus CDS
    CCDS41788.1
    UniProtKB/Swiss-Prot
    P23588
    Related
    ENSP00000262056.9, ENST00000262056.13
    Conserved Domains (3) summary
    cd12402
    Location:95171
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
    cl25574
    Location:372608
    TOP2c; TopoisomeraseII
    cl28310
    Location:158273
    Rho; Transcription termination factor Rho [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53006456..53042215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018507.1: Suppressed sequence

    Description
    NM_018507.1: This RefSeq was permanently suppressed because it is primarily 3'' UTR sequence and it is on the wrong strand compared to other mRNA transcripts for the gene.
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