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Eif4b eukaryotic translation initiation factor 4B [ Mus musculus (house mouse) ]

Gene ID: 75705, updated on 18-Jun-2024

Summary

Official Symbol
Eif4bprovided by MGI
Official Full Name
eukaryotic translation initiation factor 4Bprovided by MGI
Primary source
MGI:MGI:95304
See related
Ensembl:ENSMUSG00000058655 AllianceGenome:MGI:95304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4a2; 2310046H11Rik
Summary
Predicted to enable RNA strand annealing activity; RNA strand-exchange activity; and ribosomal small subunit binding activity. Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol; dendrite; and neuronal cell body. Orthologous to human EIF4B (eukaryotic translation initiation factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 66.8), placenta adult (RPKM 58.0) and 28 other tissues See more
Orthologs
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Genomic context

See Eif4b in Genome Data Viewer
Location:
15 F2; 15 57.26 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101982208..102005608)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102073773..102097173)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 18 Neighboring gene predicted gene, 41405 Neighboring gene STARR-seq mESC enhancer starr_39815 Neighboring gene predicted gene, 53915 Neighboring gene tensin 2 Neighboring gene SPRY domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E482

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4B
Names
eIF-4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145625.3NP_663600.2  eukaryotic translation initiation factor 4B

    See identical proteins and their annotated locations for NP_663600.2

    Status: VALIDATED

    Source sequence(s)
    AK045250, CD563487, CO043713
    Consensus CDS
    CCDS49737.1
    UniProtKB/Swiss-Prot
    Q3TD64, Q8BGD9
    UniProtKB/TrEMBL
    Q3TSY9, Q3UGC0
    Related
    ENSMUSP00000127774.2, ENSMUST00000169681.3
    Conserved Domains (3) summary
    COG0724
    Location:83256
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:95171
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins
    pfam08648
    Location:225290
    DUF1777; Protein of unknown function (DUF1777)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101982208..102005608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)