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EIF4A1 eukaryotic translation initiation factor 4A1 [ Homo sapiens (human) ]

Gene ID: 1973, updated on 5-Jul-2020

Summary

Official Symbol
EIF4A1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4A1provided by HGNC
Primary source
HGNC:HGNC:3282
See related
Ensembl:ENSG00000161960 MIM:602641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I
Expression
Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues See more
Orthologs

Genomic context

See EIF4A1 in Genome Data Viewer
Location:
17p13.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7572825..7579006)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7476024..7482324)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TNFSF12-TNFSF13 readthrough Neighboring gene TNF superfamily member 13 Neighboring gene SENP3-EIF4A1 readthrough (NMD candidate) Neighboring gene SUMO specific peptidase 3 Neighboring gene small nucleolar RNA, H/ACA box 48 Neighboring gene small nucleolar RNA, C/D box 10 Neighboring gene small nucleolar RNA, H/ACA box 67 Neighboring gene uncharacterized LOC100996842 Neighboring gene CD68 molecule Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene SRY-box transcription factor 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA cap binding TAS
Traceable Author Statement
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity TAS
Traceable Author Statement
more info
PubMed 
mRNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic initiation factor 4A-I
Names
ATP-dependent RNA helicase eIF4A-1
eukaryotic initiation factor 4AI
eukaryotic translation initiation factor 4A, isoform 1
NP_001191439.1
NP_001407.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204510.2NP_001191439.1  eukaryotic initiation factor 4A-I isoform 2

    See identical proteins and their annotated locations for NP_001191439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA446856, AC016876, BC006210, BG284868
    Consensus CDS
    CCDS58511.1
    UniProtKB/Swiss-Prot
    P60842
    Related
    ENSP00000463486.1, ENST00000577269.5
    Conserved Domains (1) summary
    cl26939
    Location:20334
    DEXDc; DEAD-like helicases superfamily
  2. NM_001416.4NP_001407.1  eukaryotic initiation factor 4A-I isoform 1

    See identical proteins and their annotated locations for NP_001407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA446856, AC016876, BG284868
    Consensus CDS
    CCDS11113.1
    UniProtKB/Swiss-Prot
    P60842
    Related
    ENSP00000293831.8, ENST00000293831.13
    Conserved Domains (1) summary
    PTZ00424
    Location:20406
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7572825..7579006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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