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Eif4a1 eukaryotic translation initiation factor 4A1 [ Mus musculus (house mouse) ]

Gene ID: 13681, updated on 8-Jan-2023

Summary

Official Symbol
Eif4a1provided by MGI
Official Full Name
eukaryotic translation initiation factor 4A1provided by MGI
Primary source
MGI:MGI:95303
See related
Ensembl:ENSMUSG00000059796 AllianceGenome:MGI:95303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif4; Ddx2a; BM-010
Summary
Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translational initiation. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; liver; lung; ovary; and sensory organ. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 322.5), placenta adult (RPKM 214.5) and 26 other tissues See more
Orthologs
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Genomic context

See Eif4a1 in Genome Data Viewer
Location:
11 B3; 11 42.86 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69557762..69563249, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69666936..69672423, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 1934 Neighboring gene CD68 antigen Neighboring gene predicted gene, 24029 Neighboring gene predicted gene, 25835 Neighboring gene predicted gene, 22988 Neighboring gene SUMO/sentrin specific peptidase 3 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
eukaryotic initiation factor 4A-I
Names
ATP-dependent RNA helicase eIF4A-1
eIF-4A-I
eIF4A-I
initiation factor eIF-4A long form
NP_001152847.1
NP_659207.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159375.1NP_001152847.1  eukaryotic initiation factor 4A-I isoform 2

    See identical proteins and their annotated locations for NP_001152847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL603707, AW493973
    UniProtKB/TrEMBL
    Q3TLL6
    Conserved Domains (3) summary
    smart00487
    Location:47249
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:246359
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:34235
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
  2. NM_144958.4NP_659207.1  eukaryotic initiation factor 4A-I isoform 1

    See identical proteins and their annotated locations for NP_659207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK169030, AL603707, AW493973
    Consensus CDS
    CCDS24904.1
    UniProtKB/Swiss-Prot
    P60843
    UniProtKB/TrEMBL
    A0A6P5QMZ6, A0A8C6N2B8, Q5F2A7
    Related
    ENSMUSP00000127034.3, ENSMUST00000163666.3
    Conserved Domains (1) summary
    PTZ00424
    Location:20406
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69557762..69563249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)