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EIF2S3 eukaryotic translation initiation factor 2 subunit gamma [ Homo sapiens (human) ]

Gene ID: 1968, updated on 5-Sep-2021

Summary

Official Symbol
EIF2S3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 2 subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:3267
See related
Ensembl:ENSG00000130741 MIM:300161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF2; EIF2G; MEHMO; MRXSBRK; eIF-2gA; EIF2gamma
Summary
The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in ovary (RPKM 61.4), lymph node (RPKM 53.4) and 25 other tissues See more
Orthologs
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Genomic context

See EIF2S3 in Genome Data Viewer
Location:
Xp22.11
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (24054956..24078810)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24073073..24096927)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein O Neighboring gene chromosome X open reading frame 58 Neighboring gene Sharpr-MPRA regulatory region 13558 Neighboring gene kelch like family member 15 Neighboring gene ZFX antisense RNA 1 Neighboring gene zinc finger protein X-linked Neighboring gene CRISPRi-validated cis-regulatory element chrX.477

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 2, subunit 3 (EIF2S3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF2S3 is increased by RRE PubMed
Tat tat Expression of HIV-1 Tat upregulates the abundance of eukaryotic translation initiation factor 2, subunit 3 gamma (EIF2S3) in the nucleoli of Jurkat T-cells PubMed
tat HIV-1 Tat competes with eukaryotic initiation factor 2, a well characterized substrate of PKR, for phosphorylation by activated PKR PubMed
tat Eukaryotic translation initiation factor 2 (eIF2) recognizes and binds the TAR secondary structure in HIV-1 RNA, suggesting a role in Tat transactivation of the viral LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation factor activity, RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 2 subunit 3
Names
eIF-2-gamma X
eIF-2gX
eukaryotic translation initiation factor 2 subunit gamma X
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
eukaryotic translation initiation factor 2G
NP_001406.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016387.1 RefSeqGene

    Range
    5009..28863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001415.4NP_001406.1  eukaryotic translation initiation factor 2 subunit 3

    See identical proteins and their annotated locations for NP_001406.1

    Status: REVIEWED

    Source sequence(s)
    AI133612, BC011945, BC019906, BF435665, CB150474
    Consensus CDS
    CCDS14210.1
    UniProtKB/Swiss-Prot
    P41091
    Related
    ENSP00000253039.4, ENST00000253039.9
    Conserved Domains (1) summary
    PTZ00327
    Location:13466
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    24054956..24078810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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