Format

Send to:

Choose Destination

EGR1 early growth response 1 [ Homo sapiens (human) ]

Gene ID: 1958, updated on 7-Jan-2019

Summary

Official Symbol
EGR1provided by HGNC
Official Full Name
early growth response 1provided by HGNC
Primary source
HGNC:HGNC:3238
See related
Ensembl:ENSG00000120738 MIM:128990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268
Summary
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in ovary (RPKM 449.0), thyroid (RPKM 344.9) and 23 other tissues See more
Orthologs

Genomic context

See EGR1 in Genome Data Viewer
Location:
5q31.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (138465492..138469315)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137801181..137805004)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene lysine demethylase 3B Neighboring gene receptor accessory protein 2 Neighboring gene ribosomal protein L7 pseudogene 19 Neighboring gene eukaryotic translation termination factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of early growth response 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in increased GFAP, Egr-1, and p300 transcription and protein expression in both Tat-expressing astrocytes, and HIV-infected astrocytes PubMed
tat HIV-1 Tat increases Egr-1 expression in human astrocytoma cells by transactivating the Egr-1 promoter and involving specific serum response elements within the promoter PubMed
tat HIV-1 Tat decreases the levels of Egr-1 and p35 expression in nerve growth factor (NGF)-treated neural cells PubMed
tat HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) PubMed
tat HIV-1 Tat upregulates EGR1 expression in Tat-infected Jurkat T cells PubMed
tat HIV-1 Tat-induced upregulation of p300 occurs at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter PubMed
tat HIV-1 Tat binds to Egr-1, an interaction that is mediated through Tat amino acids 30-40 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to heparin ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-8 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mycophenolic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian temperature homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
estrous cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular mesangial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glomerular metanephric mesangial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hormone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-1 beta biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of progesterone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
early growth response protein 1
Names
EGR-1
nerve growth factor-induced protein A
transcription factor ETR103
transcription factor Zif268
zinc finger protein 225
zinc finger protein Krox-24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021374.1 RefSeqGene

    Range
    5001..8824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001964.3NP_001955.1  early growth response protein 1

    See identical proteins and their annotated locations for NP_001955.1

    Status: REVIEWED

    Source sequence(s)
    AC113403
    Consensus CDS
    CCDS4206.1
    UniProtKB/Swiss-Prot
    P18146
    UniProtKB/TrEMBL
    Q546S1
    Related
    ENSP00000239938.4, ENST00000239938.4
    Conserved Domains (5) summary
    sd00017
    Location:340362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam11914
    Location:447530
    DUF3432; Domain of unknown function (DUF3432)
    pfam00096
    Location:338362
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:135209
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:382407
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    138465492..138469315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center