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Egr1 early growth response 1 [ Mus musculus (house mouse) ]

Gene ID: 13653, updated on 5-May-2019

Summary

Official Symbol
Egr1provided by MGI
Official Full Name
early growth response 1provided by MGI
Primary source
MGI:MGI:95295
See related
Ensembl:ENSMUSG00000038418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik
Expression
Broad expression in thymus adult (RPKM 50.4), ovary adult (RPKM 42.9) and 21 other tissues See more
Orthologs

Genomic context

See Egr1 in Genome Data Viewer
Location:
18 B1; 18 18.76 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (34861207..34864956)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (35020861..35024610)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 2 Neighboring gene predicted gene, 41689 Neighboring gene eukaryotic translation termination factor 1 Neighboring gene heat shock protein 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystem
    Ovarian Infertility Genes
  • Prion diseases, organism-specific biosystem (from KEGG)
    Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Prion diseases, conserved biosystem (from KEGG)
    Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded methylated DNA binding ISO
Inferred from Sequence Orthology
more info
 
hemi-methylated DNA-binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heparin ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-8 ISO
Inferred from Sequence Orthology
more info
 
cellular response to mycophenolic acid ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glomerular metanephric mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-1 beta biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of progesterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
early growth response protein 1
Names
Krox-24 nuclear protein
nerve growth factor-induced protein A
transcription factor Zif268
zinc finger protein Krox-24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007913.5NP_031939.1  early growth response protein 1

    See identical proteins and their annotated locations for NP_031939.1

    Status: VALIDATED

    Source sequence(s)
    AK037837, AK040925
    Consensus CDS
    CCDS29136.1
    UniProtKB/Swiss-Prot
    P08046
    UniProtKB/TrEMBL
    Q544D6, Q8CAT6
    Related
    ENSMUSP00000069616.5, ENSMUST00000064795.5
    Conserved Domains (7) summary
    COG5048
    Location:363421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:336360
    zf-C2H2; Zinc finger, C2H2 type
    pfam05687
    Location:441478
    BES1_N; BES1/BZR1 plant transcription factor, N-terminal
    pfam11914
    Location:426520
    DUF3432; Domain of unknown function (DUF3432)
    pfam11928
    Location:132207
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:380405
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    34861207..34864956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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