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Egr1 early growth response 1 [ Mus musculus (house mouse) ]

Gene ID: 13653, updated on 23-Oct-2022

Summary

Official Symbol
Egr1provided by MGI
Official Full Name
early growth response 1provided by MGI
Primary source
MGI:MGI:95295
See related
Ensembl:ENSMUSG00000038418 AllianceGenome:MGI:95295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
egr; TIS8; Zenk; Egr-1; NGFIA; Zfp-6; ETR103; Krox-1; Krox24; NGF1-A; NGFI-A; Zif268; Krox-24; A530045N19Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to gamma radiation; regulation of gene expression; and regulation of hormone biosynthetic process. Acts upstream of or within several processes, including BMP signaling pathway; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and jaw. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 50.4), ovary adult (RPKM 42.9) and 21 other tissues See more
Orthologs
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Genomic context

See Egr1 in Genome Data Viewer
Location:
18 B1; 18 18.76 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34994260..34998009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34861207..34864956)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene KDM3B lysine (K)-specific demethylase 3B Neighboring gene receptor accessory protein 2 Neighboring gene predicted gene, 54018 Neighboring gene eukaryotic translation termination factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded methylated DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables hemi-methylated DNA-binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to heparin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-8 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mycophenolic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerular metanephric mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of post-translational protein modification ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of progesterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
early growth response protein 1
Names
Krox-24 nuclear protein
nerve growth factor-induced protein A
transcription factor Zif268
zinc finger protein Krox-24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007913.5NP_031939.1  early growth response protein 1

    See identical proteins and their annotated locations for NP_031939.1

    Status: VALIDATED

    Source sequence(s)
    AK037837, AK040925
    Consensus CDS
    CCDS29136.1
    UniProtKB/Swiss-Prot
    P08046, Q61777
    UniProtKB/TrEMBL
    Q544D6, Q8CAT6
    Related
    ENSMUSP00000069616.6, ENSMUST00000064795.6
    Conserved Domains (7) summary
    COG5048
    Location:363421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338360
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:336360
    zf-C2H2; Zinc finger, C2H2 type
    pfam05687
    Location:441478
    BES1_N; BES1/BZR1 plant transcription factor, N-terminal
    pfam11914
    Location:426520
    DUF3432; Domain of unknown function (DUF3432)
    pfam11928
    Location:132207
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:380405
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34994260..34998009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)