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Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 [ Mus musculus (house mouse) ]

Gene ID: 19418, updated on 29-Nov-2022

Summary

Official Symbol
Rasgrf2provided by MGI
Official Full Name
RAS protein-specific guanine nucleotide-releasing factor 2provided by MGI
Primary source
MGI:MGI:109137
See related
Ensembl:ENSMUSG00000021708 AllianceGenome:MGI:109137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grf2; Ras-GRF2; 6330417G04Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within long-term synaptic potentiation and regulation of NMDA receptor activity. Predicted to be located in endoplasmic reticulum. Is expressed in brain; hypothalamus mantle layer; medulla oblongata basal plate mantle layer; and pons mantle layer. Orthologous to human RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 11.9), cortex adult (RPKM 11.9) and 14 other tissues See more
Orthologs
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Genomic context

See Rasgrf2 in Genome Data Viewer
Location:
13 C3; 13 47.43 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92028526..92268584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (91880407..92131828, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger, CCHC domain containing 9 Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene predicted gene, 46435 Neighboring gene mutS homolog 3 Neighboring gene predicted gene, 20379 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene dihydrofolate reductase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-specific guanine nucleotide-releasing factor 2
Names
ras guanine nucleotide exchange factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009027.4NP_033053.2  ras-specific guanine nucleotide-releasing factor 2

    See identical proteins and their annotated locations for NP_033053.2

    Status: VALIDATED

    Source sequence(s)
    AC146698, AC167972, U67326
    UniProtKB/Swiss-Prot
    P70392, Q9QX51
    Related
    ENSMUSP00000116892.3, ENSMUST00000151408.9
    Conserved Domains (7) summary
    smart00147
    Location:9501186
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:852924
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    smart00233
    Location:480588
    PH; Pleckstrin homology domain
    cd13261
    Location:19158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:24133
    PH; PH domain
    pfam00618
    Location:638686
    RasGEF_N; RasGEF N-terminal motif
    pfam00621
    Location:247428
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    92028526..92268584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157921.1XP_036013814.1  ras-specific guanine nucleotide-releasing factor 2 isoform X1

    Conserved Domains (6) summary
    smart00147
    Location:9511187
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00233
    Location:480588
    PH; Pleckstrin homology domain
    smart00325
    Location:247428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:638686
    RasGEF_N; RasGEF N-terminal motif
    cl02520
    Location:853925
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
  2. XM_036157922.1XP_036013815.1  ras-specific guanine nucleotide-releasing factor 2 isoform X2

    Conserved Domains (4) summary
    smart00233
    Location:480588
    PH; Pleckstrin homology domain
    smart00325
    Location:247428
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd13261
    Location:19158
    PH_RasGRF1_2; Ras-specific guanine nucleotide-releasing factors 1 and 2 Pleckstrin homology (PH) domain
    pfam00618
    Location:638686
    RasGEF_N; RasGEF N-terminal motif