2II0


Conserved Protein Domain Family
RasGEFN

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smart00229: RasGEFN 
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Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).
Statistics
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PSSM-Id: 214571
Aligned: 27 rows
Threshold Bit Score: 79.3006
Threshold Setting Gi: 151944873
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2II0_A        38 GIPIIKAGTVIKLIERLTYHMY-----A-----DPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPe------------ 95  human
AAC52724      88 SSRRLRAGTLEALVRHLLDARTa---gA-----DMMFTPALLATHRAFTSTPALFGLVADRLEALESy------------ 147 house mouse
AAA83583      46 KEKLIKAGTVERLVECLVGSDDm----M-----DSRHFNVFFATYRSFTDSAIVLDCLLRRYETLENe------------ 104 Caenorhabditis ...
AAB00628      30 NTGAVLSGSRDALIRRLVPTRDf---cP-----DESYIFSLLVNIRTFISPHELMQKIVQVRIFIPEefhplldtdnlsh 101 Caenorhabditis ...
CAA37345     489 QDGKIKTATLVFIINYLLRTDI-----D-----STFFTTIFLNTYASMISSSDLFSILGAHFRFICSlnf---------- 548 fission yeast
Q03386       112 KVRTVKAGTLEKLVEHLVPAFQg----S-----DLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPy------------ 170 Norway rat
NP_058542     65 KIRTIKAGTLEKLVENLLTAFGd----N-----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTGp------------ 123 house mouse
NP_062084     53 lGHLAKGASLDDLIDSCIQSFDa----DgnlcrSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALE------------- 115 Norway rat
NP_001164963   4 TLDLDKGCTVEELLRGCIEAFDdsgkvR-----DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQ----------------- 61  rabbit
EGA75820     120 EVFRIQ-LYLNKMLPHNSHKWQk----P-----SPFDSANLLLNFRDWTTDNALLQELLLSYPTINKn------------ 177 Saccharomyces c...
AAC52724      88 SSRRLRAGTLEALVRHLLDARTa---gA-----DMMFTPALLATHRAFTSTPALFGLVADRLEALESy------------ 147 house mouse
AAA83583      46 KEKLIKAGTVERLVECLVGSDDm----M-----DSRHFNVFFATYRSFTDSAIVLDCLLRRYETLENe------------ 104 Caenorhabditis ...
AAB00628      30 NTGAVLSGSRDALIRRLVPTRDf---cP-----DESYIFSLLVNIRTFISPHELMQKIVQVRIFIPEefhplldtdnlsh 101 Caenorhabditis ...
CAA37345     489 QDGKIKTATLVFIINYLLRTDI-----D-----STFFTTIFLNTYASMISSSDLFSILGAHFRFICSlnf---------- 548 fission yeast
Q03386       112 KVRTVKAGTLEKLVEHLVPAFQg----S-----DLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPy------------ 170 Norway rat
NP_058542     65 KIRTIKAGTLEKLVENLLTAFGd----N-----DFTYISIFLSTYRGFASTKEVLELLLDRYGNLTGp------------ 123 house mouse
NP_062084     53 lGHLAKGASLDDLIDSCIQSFDa----DgnlcrSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALE------------- 115 Norway rat
NP_001164963   4 TLDLDKGCTVEELLRGCIEAFDdsgkvR-----DPQLVRMFLMMHPWYIPSSQLAAKLLHIYQ----------------- 61  rabbit
EGA75820     120 EVFRIQ-LYLNKMLPHNSHKWQk----P-----SPFDSANLLLNFRDWTTDNALLQELLLSYPTINKn------------ 177 Saccharomyces c...
2II0_A        96 --------------PTeadriaiengdqplsaelkRFRKEYIqpVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEE--F- 158 human
AAC52724     148 -------------------------------------PPGELerTTGVAISVLSTWLASHPEDFGSEVKGQLDRLE--S- 187 house mouse
AAA83583     105 -----------------------------------VNGSTSAllVQNSIRQIVMCWLETYPEDFYDSDKDFAMLSS--L- 146 Caenorhabditis ...
AAB00628     102 lsaqiycmfaqnadSH-------------------NFAKEGRgrMFAHILRLCSEWATNIPYDFKTEY-MRTRLNEllR- 160 Caenorhabditis ...
CAA37345     549 -------------gkI-------------------SFISHEFyrVSKRFLDILLIWFESYLVEELDNSKSIFFLFK--I- 593 fission yeast
Q03386       171 --------------S--------------------SEDGGPQdqLKNAISSILGTWLDQYSEDFCQPP-DFPCLKQ--Lv 213 Norway rat
NP_058542    124 --------------NCedd--------------gsQSSPESKavIRNAIASILRAWLDQCAEDFREPPH-FPCLQK--L- 171 house mouse
NP_062084    116 ---------------------------------------KNSpgICLKICYFVRYWITEFWIMFKMDASLTSTMEE--F- 153 Norway rat
NP_001164963  62 -----------------------------------QSRKDNSssLQVKTCHLVRYWISAFPAEFDLNPELAEQIKE--L- 103 rabbit
EGA75820     178 --------------KH-------------------KN---------HSVPRLIQIWVESYWQDSETTLKDILNFW---Y- 211 Saccharomyces c...
AAC52724     148 -------------------------------------PPGELerTTGVAISVLSTWLASHPEDFGSEVKGQLDRLE--S- 187 house mouse
AAA83583     105 -----------------------------------VNGSTSAllVQNSIRQIVMCWLETYPEDFYDSDKDFAMLSS--L- 146 Caenorhabditis ...
AAB00628     102 lsaqiycmfaqnadSH-------------------NFAKEGRgrMFAHILRLCSEWATNIPYDFKTEY-MRTRLNEllR- 160 Caenorhabditis ...
CAA37345     549 -------------gkI-------------------SFISHEFyrVSKRFLDILLIWFESYLVEELDNSKSIFFLFK--I- 593 fission yeast
Q03386       171 --------------S--------------------SEDGGPQdqLKNAISSILGTWLDQYSEDFCQPP-DFPCLKQ--Lv 213 Norway rat
NP_058542    124 --------------NCedd--------------gsQSSPESKavIRNAIASILRAWLDQCAEDFREPPH-FPCLQK--L- 171 house mouse
NP_062084    116 ---------------------------------------KNSpgICLKICYFVRYWITEFWIMFKMDASLTSTMEE--F- 153 Norway rat
NP_001164963  62 -----------------------------------QSRKDNSssLQVKTCHLVRYWISAFPAEFDLNPELAEQIKE--L- 103 rabbit
EGA75820     178 --------------KH-------------------KN---------HSVPRLIQIWVESYWQDSETTLKDILNFW---Y- 211 Saccharomyces c...
2II0_A       159 IG-TVRGK---AMKKWVESITKIIQRKK 182 human
AAC52724     188 FL-LRTGYa--AREGVVGGSADLIRNLR 212 house mouse
AAA83583     147 LD-FGGRNkltELRAKARKQREVFKRIY 173 Caenorhabditis elegans
AAB00628     161 LC-AVDKT----YQQKTTELQSTLRSSV 183 Caenorhabditis elegans
CAA37345     594 YK-VFEVF----VVPHFASAEELLHSLS 616 fission yeast
Q03386       214 AY-VQLNM---PGSDLERRAHLLLAQLe 237 Norway rat
NP_058542    172 LEyLKQMM---PGSDPERRAQNLLEQFQ 196 house mouse
NP_062084    154 QD-LVKAN----GEESHCHLIDTTQINS 176 Norway rat
NP_001164963 104 KA-LLDQE----GNRRHSNLIDIdsvpt 126 rabbit
EGA75820     212 SH-LAEYY---EYQELFADIVQLFINKK 235 Saccharomyces cerevisiae AWRI796
AAC52724     188 FL-LRTGYa--AREGVVGGSADLIRNLR 212 house mouse
AAA83583     147 LD-FGGRNkltELRAKARKQREVFKRIY 173 Caenorhabditis elegans
AAB00628     161 LC-AVDKT----YQQKTTELQSTLRSSV 183 Caenorhabditis elegans
CAA37345     594 YK-VFEVF----VVPHFASAEELLHSLS 616 fission yeast
Q03386       214 AY-VQLNM---PGSDLERRAHLLLAQLe 237 Norway rat
NP_058542    172 LEyLKQMM---PGSDPERRAQNLLEQFQ 196 house mouse
NP_062084    154 QD-LVKAN----GEESHCHLIDTTQINS 176 Norway rat
NP_001164963 104 KA-LLDQE----GNRRHSNLIDIdsvpt 126 rabbit
EGA75820     212 SH-LAEYY---EYQELFADIVQLFINKK 235 Saccharomyces cerevisiae AWRI796
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