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Ptprs protein tyrosine phosphatase receptor type S [ Mus musculus (house mouse) ]

Gene ID: 19280, updated on 12-May-2024

Summary

Official Symbol
Ptprsprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Sprovided by MGI
Primary source
MGI:MGI:97815
See related
Ensembl:ENSMUSG00000013236 AllianceGenome:MGI:97815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTP; Ptpt9; PTP-NU3; PTPNU-3; R-PTP-S; PTPsigma; RPTPsigma
Summary
Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 169.2), CNS E14 (RPKM 151.8) and 22 other tissues See more
Orthologs
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Genomic context

See Ptprs in Genome Data Viewer
Location:
17 D; 17 29.32 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56719426..56783480, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56412426..56476561, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3208 Neighboring gene STARR-positive B cell enhancer ABC_E3209 Neighboring gene ubiquitin-like, containing PHD and RING finger domains, 1 Neighboring gene STARR-positive B cell enhancer ABC_E141 Neighboring gene lysine (K)-specific demethylase 4B Neighboring gene STARR-positive B cell enhancer ABC_E8923 Neighboring gene predicted gene, 32715 Neighboring gene microRNA 6977 Neighboring gene STARR-positive B cell enhancer ABC_E5622 Neighboring gene STARR-positive B cell enhancer mm9_chr17:56601992-56602293 Neighboring gene predicted gene, 32822 Neighboring gene predicted gene 9258 Neighboring gene predicted gene, 33089 Neighboring gene predicted gene, 33211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90571

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chondroitin sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within corpus callosum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor 9 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in trans-synaptic signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in trans-synaptic signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase S
Names
R-PTP-sigma
Receptor-type tyrosine-protein phosphatase sigma
tissue-specific protein tyrosine phosphatase
NP_001239382.1
NP_001239384.1
NP_001239385.1
NP_035348.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252453.1NP_001239382.1  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    BC052462, CT009637
    Consensus CDS
    CCDS57103.1
    UniProtKB/Swiss-Prot
    B0V2N1
    Conserved Domains (6) summary
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd14625
    Location:9231204
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:12061495
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  2. NM_001252455.1NP_001239384.1  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

    See identical proteins and their annotated locations for NP_001239384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks 5 exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AI845699, BC083188, CT009637
    Consensus CDS
    CCDS89125.1
    UniProtKB/Swiss-Prot
    B0V2N1
    Related
    ENSMUSP00000153134.2, ENSMUST00000223859.2
    Conserved Domains (6) summary
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12281487
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9671196
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
  3. NM_001252456.1NP_001239385.1  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239385.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks four consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter than isoform 1.
    Source sequence(s)
    CT009637
    Consensus CDS
    CCDS57103.1
    UniProtKB/Swiss-Prot
    B0V2N1
    Related
    ENSMUSP00000084038.4, ENSMUST00000086828.10
    Conserved Domains (6) summary
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd14625
    Location:9231204
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:12061495
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  4. NM_011218.2NP_035348.2  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

    See identical proteins and their annotated locations for NP_035348.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI845699, AK163915, BC083188, CJ177868, D28530
    Consensus CDS
    CCDS37664.1
    UniProtKB/Swiss-Prot
    B0V2N1, Q3TEC3, Q3TXC9, Q4JFC7, Q5XJV4, Q64503, Q64699, Q7TT17
    Related
    ENSMUSP00000064048.6, ENSMUST00000067538.6
    Conserved Domains (6) summary
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd14625
    Location:13291610
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16121901
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56719426..56783480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)