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PTPRS protein tyrosine phosphatase receptor type S [ Homo sapiens (human) ]

Gene ID: 5802, updated on 23-Nov-2023

Summary

Official Symbol
PTPRSprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Sprovided by HGNC
Primary source
HGNC:HGNC:9681
See related
Ensembl:ENSG00000105426 MIM:601576; AllianceGenome:HGNC:9681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R-PTP-S; PTPSIGMA; R-PTP-sigma
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 30.9), brain (RPKM 23.8) and 23 other tissues See more
Orthologs
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Genomic context

See PTPRS in Genome Data Viewer
Location:
19p13.3
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5205508..5340812, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5192102..5327425, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5205519..5340823, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4983945-4984871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4988552-4989057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4989058-4989562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4989779-4990280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4990281-4990780 Neighboring gene Sharpr-MPRA regulatory region 13405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5004333-5004833 Neighboring gene lysine demethylase 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5026529-5027028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5036688-5037262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5042227-5042746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5042747-5043265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5046625-5047428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5048922-5049524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5052015-5052514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5083429-5084111 Neighboring gene Sharpr-MPRA regulatory region 3293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5092687-5093236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5093237-5093784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5096761-5097261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5096260-5096760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5095749-5096249 Neighboring gene Sharpr-MPRA regulatory region 7356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5109710-5110566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5111029-5111538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5114178-5115133 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5115134-5116088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5121454-5121994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5125360-5125896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5125897-5126434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5126435-5126971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5126972-5127509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5128585-5129120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5129121-5129658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5129659-5130195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5130196-5130732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5130733-5131269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5137253-5137754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5137755-5138254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5151275-5152046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5153977-5154477 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5165571-5165790 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:5172675-5173874 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5173956-5174147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13799 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5191478-5192140 Neighboring gene PTPRS antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5225323-5225942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5225943-5226561 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5247733-5247924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5268923-5269423 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9920 Neighboring gene uncharacterized LOC105372253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5294563-5295180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5295181-5295797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5298210-5298710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5301231-5301731 Neighboring gene ribosomal protein L32 pseudogene 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5319701-5320202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5320203-5320702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13801 Neighboring gene uncharacterized LOC105372252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5338211-5338884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5364893-5365392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5395257-5395803 Neighboring gene Sharpr-MPRA regulatory region 11104 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51701 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5477057-5477274 Neighboring gene uncharacterized LOC124904622 Neighboring gene zinc and ring finger 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRS PubMed
Knockdown of protein tyrosine phosphatase, receptor type, Sigma (PTPRS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparan sulfate proteoglycan binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in corpus callosum development IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of collateral sprouting ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord development IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trans-synaptic signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase S
Names
protein tyrosine phosphatase PTPsigma
receptor-type tyrosine-protein phosphatase sigma
NP_001380940.1
NP_001380941.1
NP_001380942.1
NP_002841.3
NP_570923.2
NP_570924.2
NP_570925.2
XP_005259657.1
XP_005259664.1
XP_005259667.1
XP_011526460.1
XP_016882554.1
XP_016882555.1
XP_016882556.1
XP_016882557.1
XP_016882558.1
XP_016882559.1
XP_016882560.1
XP_016882561.1
XP_016882562.1
XP_016882563.1
XP_016882564.1
XP_047295111.1
XP_047295112.1
XP_047295113.1
XP_047295114.1
XP_047295115.1
XP_047295116.1
XP_047295117.1
XP_047295118.1
XP_047295119.1
XP_047295120.1
XP_047295121.1
XP_047295122.1
XP_047295123.1
XP_054177576.1
XP_054177577.1
XP_054177578.1
XP_054177579.1
XP_054177580.1
XP_054177581.1
XP_054177582.1
XP_054177583.1
XP_054177584.1
XP_054177585.1
XP_054177586.1
XP_054177587.1
XP_054177588.1
XP_054177589.1
XP_054177590.1
XP_054177591.1
XP_054177592.1
XP_054177593.1
XP_054177594.1
XP_054177595.1
XP_054177596.1
XP_054177597.1
XP_054177598.1
XP_054177599.1
XP_054177600.1
XP_054177601.1
XP_054177602.1
XP_054177603.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033964.1 RefSeqGene

    Range
    4992..140296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394011.1NP_001380940.1  receptor-type tyrosine-protein phosphatase S isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005335, AC005338, AC005788, AC005790, AC118535
    Conserved Domains (7) summary
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:238315
    IG; Immunoglobulin
    smart00410
    Location:39124
    IG_like; Immunoglobulin like
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13481629
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16311920
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    cd00096
    Location:165169
    Ig; Ig strand C [structural motif]
  2. NM_001394012.1NP_001380941.1  receptor-type tyrosine-protein phosphatase S isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005335, AC005338, AC005788, AC005790, AC118535
    Conserved Domains (7) summary
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:238315
    IG; Immunoglobulin
    smart00410
    Location:39124
    IG_like; Immunoglobulin like
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13411622
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16241913
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    cd00096
    Location:165169
    Ig; Ig strand C [structural motif]
  3. NM_001394013.1NP_001380942.1  receptor-type tyrosine-protein phosphatase S isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005335, AC005338, AC005788, AC005790, AC118535
    Conserved Domains (8) summary
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13281609
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16111900
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam18861
    Location:11861285
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:137226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:235316
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  4. NM_002850.4NP_002841.3  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

    See identical proteins and their annotated locations for NP_002841.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
    Consensus CDS
    CCDS45930.1
    UniProtKB/Swiss-Prot
    O75255, O75870, Q13332, Q15718, Q16341, Q2M3R7
    Related
    ENSP00000262963.8, ENST00000262963.11
    Conserved Domains (8) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:259327
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13921647
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141234
    IG_like; Immunoglobulin like
    cd00047
    Location:14181647
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:332421
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  5. NM_130853.3NP_570923.2  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

    See identical proteins and their annotated locations for NP_570923.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812
    Consensus CDS
    CCDS12139.1
    UniProtKB/TrEMBL
    G8JL96
    Related
    ENSP00000467398.1, ENST00000592099.5
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9451200
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9711200
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  6. NM_130854.3NP_570924.2  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

    See identical proteins and their annotated locations for NP_570924.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
    Consensus CDS
    CCDS12140.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Related
    ENSP00000465443.1, ENST00000588012.5
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13541609
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:13801609
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  7. NM_130855.3NP_570925.2  receptor-type tyrosine-protein phosphatase S isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812, U35234
    UniProtKB/TrEMBL
    G8JL96
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9491204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9751204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    5205508..5340812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439166.1XP_047295122.1  receptor-type tyrosine-protein phosphatase S isoform X19

    UniProtKB/TrEMBL
    G8JL96
  2. XM_047439164.1XP_047295120.1  receptor-type tyrosine-protein phosphatase S isoform X17

    UniProtKB/TrEMBL
    G8JL96
  3. XM_047439162.1XP_047295118.1  receptor-type tyrosine-protein phosphatase S isoform X16

    UniProtKB/TrEMBL
    G8JL96
  4. XM_047439161.1XP_047295117.1  receptor-type tyrosine-protein phosphatase S isoform X9

  5. XM_047439155.1XP_047295111.1  receptor-type tyrosine-protein phosphatase S isoform X3

  6. XM_017027066.2XP_016882555.1  receptor-type tyrosine-protein phosphatase S isoform X1

    UniProtKB/Swiss-Prot
    Q13332
  7. XM_005259610.2XP_005259667.1  receptor-type tyrosine-protein phosphatase S isoform X19

    UniProtKB/TrEMBL
    G8JL96
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9411196
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9671196
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  8. XM_047439163.1XP_047295119.1  receptor-type tyrosine-protein phosphatase S isoform X16

    UniProtKB/TrEMBL
    G8JL96
  9. XM_005259607.3XP_005259664.1  receptor-type tyrosine-protein phosphatase S isoform X12

    Conserved Domains (8) summary
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13281609
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16111900
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam18861
    Location:11861285
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:137226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:235316
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  10. XM_047439160.1XP_047295116.1  receptor-type tyrosine-protein phosphatase S isoform X9

  11. XM_047439159.1XP_047295115.1  receptor-type tyrosine-protein phosphatase S isoform X7

  12. XM_047439157.1XP_047295113.1  receptor-type tyrosine-protein phosphatase S isoform X4

  13. XM_005259600.3XP_005259657.1  receptor-type tyrosine-protein phosphatase S isoform X3

    See identical proteins and their annotated locations for XP_005259657.1

    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13791634
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:14051634
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  14. XM_047439165.1XP_047295121.1  receptor-type tyrosine-protein phosphatase S isoform X18

    UniProtKB/TrEMBL
    G8JL96
  15. XM_017027075.2XP_016882564.1  receptor-type tyrosine-protein phosphatase S isoform X15

    UniProtKB/TrEMBL
    G8JL96
  16. XM_017027074.2XP_016882563.1  receptor-type tyrosine-protein phosphatase S isoform X14

    UniProtKB/TrEMBL
    G8JL96
  17. XM_017027072.2XP_016882561.1  receptor-type tyrosine-protein phosphatase S isoform X11

  18. XM_047439158.1XP_047295114.1  receptor-type tyrosine-protein phosphatase S isoform X6

  19. XM_017027069.2XP_016882558.1  receptor-type tyrosine-protein phosphatase S isoform X5

  20. XM_017027071.2XP_016882560.1  receptor-type tyrosine-protein phosphatase S isoform X10

  21. XM_017027068.2XP_016882557.1  receptor-type tyrosine-protein phosphatase S isoform X2

  22. XM_017027070.2XP_016882559.1  receptor-type tyrosine-protein phosphatase S isoform X8

  23. XM_017027065.2XP_016882554.1  receptor-type tyrosine-protein phosphatase S isoform X1

    UniProtKB/Swiss-Prot
    Q13332
  24. XM_047439156.1XP_047295112.1  receptor-type tyrosine-protein phosphatase S isoform X3

  25. XM_017027067.2XP_016882556.1  receptor-type tyrosine-protein phosphatase S isoform X1

    UniProtKB/Swiss-Prot
    Q13332
  26. XM_017027073.2XP_016882562.1  receptor-type tyrosine-protein phosphatase S isoform X13

  27. XM_047439167.1XP_047295123.1  receptor-type tyrosine-protein phosphatase S isoform X21

  28. XM_011528158.3XP_011526460.1  receptor-type tyrosine-protein phosphatase S isoform X20

    Conserved Domains (3) summary
    smart00194
    Location:601856
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:627856
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:141238
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    5192102..5327425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321626.1XP_054177601.1  receptor-type tyrosine-protein phosphatase S isoform X19

    UniProtKB/TrEMBL
    G8JL96
  2. XM_054321623.1XP_054177598.1  receptor-type tyrosine-protein phosphatase S isoform X17

    UniProtKB/TrEMBL
    G8JL96
  3. XM_054321621.1XP_054177596.1  receptor-type tyrosine-protein phosphatase S isoform X16

    UniProtKB/TrEMBL
    G8JL96
  4. XM_054321614.1XP_054177589.1  receptor-type tyrosine-protein phosphatase S isoform X9

  5. XM_054321606.1XP_054177581.1  receptor-type tyrosine-protein phosphatase S isoform X3

  6. XM_054321601.1XP_054177576.1  receptor-type tyrosine-protein phosphatase S isoform X1

  7. XM_054321622.1XP_054177597.1  receptor-type tyrosine-protein phosphatase S isoform X16

    UniProtKB/TrEMBL
    G8JL96
  8. XM_054321602.1XP_054177577.1  receptor-type tyrosine-protein phosphatase S isoform X1

  9. XM_054321624.1XP_054177599.1  receptor-type tyrosine-protein phosphatase S isoform X18

    UniProtKB/TrEMBL
    G8JL96
  10. XM_054321620.1XP_054177595.1  receptor-type tyrosine-protein phosphatase S isoform X15

    UniProtKB/TrEMBL
    G8JL96
  11. XM_054321619.1XP_054177594.1  receptor-type tyrosine-protein phosphatase S isoform X14

    UniProtKB/TrEMBL
    G8JL96
  12. XM_054321616.1XP_054177591.1  receptor-type tyrosine-protein phosphatase S isoform X11

  13. XM_054321610.1XP_054177585.1  receptor-type tyrosine-protein phosphatase S isoform X6

  14. XM_054321609.1XP_054177584.1  receptor-type tyrosine-protein phosphatase S isoform X5

  15. XM_054321615.1XP_054177590.1  receptor-type tyrosine-protein phosphatase S isoform X10

  16. XM_054321604.1XP_054177579.1  receptor-type tyrosine-protein phosphatase S isoform X2

  17. XM_054321612.1XP_054177587.1  receptor-type tyrosine-protein phosphatase S isoform X8

  18. XM_054321625.1XP_054177600.1  receptor-type tyrosine-protein phosphatase S isoform X19

    UniProtKB/TrEMBL
    G8JL96
  19. XM_054321617.1XP_054177592.1  receptor-type tyrosine-protein phosphatase S isoform X12

  20. XM_054321613.1XP_054177588.1  receptor-type tyrosine-protein phosphatase S isoform X9

  21. XM_054321611.1XP_054177586.1  receptor-type tyrosine-protein phosphatase S isoform X7

  22. XM_054321608.1XP_054177583.1  receptor-type tyrosine-protein phosphatase S isoform X4

  23. XM_054321605.1XP_054177580.1  receptor-type tyrosine-protein phosphatase S isoform X3

  24. XM_054321607.1XP_054177582.1  receptor-type tyrosine-protein phosphatase S isoform X3

  25. XM_054321603.1XP_054177578.1  receptor-type tyrosine-protein phosphatase S isoform X1

  26. XM_054321618.1XP_054177593.1  receptor-type tyrosine-protein phosphatase S isoform X13

  27. XM_054321628.1XP_054177603.1  receptor-type tyrosine-protein phosphatase S isoform X21

  28. XM_054321627.1XP_054177602.1  receptor-type tyrosine-protein phosphatase S isoform X20