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PTPRS protein tyrosine phosphatase receptor type S [ Homo sapiens (human) ]

Gene ID: 5802, updated on 5-Jan-2022

Summary

Official Symbol
PTPRSprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Sprovided by HGNC
Primary source
HGNC:HGNC:9681
See related
Ensembl:ENSG00000105426 MIM:601576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R-PTP-S; PTPSIGMA; R-PTP-sigma
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 30.9), brain (RPKM 23.8) and 23 other tissues See more
Orthologs
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Genomic context

See PTPRS in Genome Data Viewer
Location:
19p13.3
Exon count:
41
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (5205503..5340812, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5205519..5340823, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ubiquitin like with PHD and ring finger domains 1 Neighboring gene microRNA 4747 Neighboring gene Sharpr-MPRA regulatory region 13405 Neighboring gene lysine demethylase 4B Neighboring gene uncharacterized LOC105372253 Neighboring gene ribosomal protein L32 pseudogene 34 Neighboring gene uncharacterized LOC105372252 Neighboring gene Sharpr-MPRA regulatory region 11104 Neighboring gene zinc and ring finger 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRS PubMed
Knockdown of protein tyrosine phosphatase, receptor type, Sigma (PTPRS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chondroitin sulfate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparan sulfate proteoglycan binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of collateral sprouting ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of postsynaptic density membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase S
Names
protein tyrosine phosphatase PTPsigma
receptor-type tyrosine-protein phosphatase sigma
NP_001380940.1
NP_001380941.1
NP_001380942.1
NP_002841.3
NP_570923.2
NP_570924.2
NP_570925.2
XP_005259657.1
XP_005259663.1
XP_005259664.1
XP_005259666.1
XP_005259667.1
XP_011526459.1
XP_011526460.1
XP_016882554.1
XP_016882555.1
XP_016882556.1
XP_016882557.1
XP_016882558.1
XP_016882559.1
XP_016882560.1
XP_016882561.1
XP_016882562.1
XP_016882563.1
XP_016882564.1
XP_016882565.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033964.1 RefSeqGene

    Range
    4992..140296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394011.1NP_001380940.1  receptor-type tyrosine-protein phosphatase S isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005335, AC005338, AC005788, AC005790, AC118535
    Conserved Domains (7) summary
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:238315
    IG; Immunoglobulin
    smart00410
    Location:39124
    IG_like; Immunoglobulin like
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13481629
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16311920
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    cd00096
    Location:165169
    Ig; Ig strand C [structural motif]
  2. NM_001394012.1NP_001380941.1  receptor-type tyrosine-protein phosphatase S isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005335, AC005338, AC005788, AC005790, AC118535
    Conserved Domains (7) summary
    smart00408
    Location:150214
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:238315
    IG; Immunoglobulin
    smart00410
    Location:39124
    IG_like; Immunoglobulin like
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13411622
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16241913
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    cd00096
    Location:165169
    Ig; Ig strand C [structural motif]
  3. NM_001394013.1NP_001380942.1  receptor-type tyrosine-protein phosphatase S isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005335, AC005338, AC005788, AC005790, AC118535
    Conserved Domains (8) summary
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13281609
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16111900
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam18861
    Location:11861285
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:137226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:235316
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  4. NM_002850.4NP_002841.3  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

    See identical proteins and their annotated locations for NP_002841.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
    Consensus CDS
    CCDS45930.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Related
    ENSP00000262963.8, ENST00000262963.11
    Conserved Domains (8) summary
    cd05738
    Location:152235
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:259327
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13921647
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141234
    IG_like; Immunoglobulin like
    cd00047
    Location:14181647
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:332421
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  5. NM_130853.3NP_570923.2  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

    See identical proteins and their annotated locations for NP_570923.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812
    Consensus CDS
    CCDS12139.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9451200
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9711200
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  6. NM_130854.3NP_570924.2  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

    See identical proteins and their annotated locations for NP_570924.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
    Consensus CDS
    CCDS12140.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    Q59FX6, Q8NHS7
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13541609
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:13801609
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  7. NM_130855.3NP_570925.2  receptor-type tyrosine-protein phosphatase S isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AB209333, AC005335, AC118535, BC029496, BC104812, U35234
    Consensus CDS
    CCDS74265.1
    UniProtKB/Swiss-Prot
    Q13332
    UniProtKB/TrEMBL
    A0A0A0MR60, Q59FX6, Q8NHS7
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9491204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9751204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    5205503..5340812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027066.1XP_016882555.1  receptor-type tyrosine-protein phosphatase S isoform X1

    UniProtKB/Swiss-Prot
    Q13332
  2. XM_005259607.2XP_005259664.1  receptor-type tyrosine-protein phosphatase S isoform X9

    Conserved Domains (8) summary
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14625
    Location:13281609
    R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
    cd14627
    Location:16111900
    R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam18861
    Location:11861285
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:137226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:235316
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  3. XM_005259606.2XP_005259663.1  receptor-type tyrosine-protein phosphatase S isoform X7

    See identical proteins and their annotated locations for XP_005259663.1

    UniProtKB/Swiss-Prot
    Q13332
    Related
    ENSP00000465443.1, ENST00000588012.5
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13541609
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:13801609
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  4. XM_005259600.2XP_005259657.1  receptor-type tyrosine-protein phosphatase S isoform X2

    See identical proteins and their annotated locations for XP_005259657.1

    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13791634
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:14051634
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  5. XM_017027072.1XP_016882561.1  receptor-type tyrosine-protein phosphatase S isoform X8

  6. XM_017027069.1XP_016882558.1  receptor-type tyrosine-protein phosphatase S isoform X4

  7. XM_017027071.1XP_016882560.1  receptor-type tyrosine-protein phosphatase S isoform X6

  8. XM_017027068.1XP_016882557.1  receptor-type tyrosine-protein phosphatase S isoform X3

  9. XM_017027070.1XP_016882559.1  receptor-type tyrosine-protein phosphatase S isoform X5

  10. XM_017027065.1XP_016882554.1  receptor-type tyrosine-protein phosphatase S isoform X1

    UniProtKB/Swiss-Prot
    Q13332
  11. XM_005259610.1XP_005259667.1  receptor-type tyrosine-protein phosphatase S isoform X15

    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9411196
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9671196
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  12. XM_005259609.1XP_005259666.1  receptor-type tyrosine-protein phosphatase S isoform X14

    See identical proteins and their annotated locations for XP_005259666.1

    UniProtKB/Swiss-Prot
    Q13332
    Related
    ENSP00000467398.1, ENST00000592099.5
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9451200
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9711200
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  13. XM_017027075.1XP_016882564.1  receptor-type tyrosine-protein phosphatase S isoform X12

  14. XM_017027076.1XP_016882565.1  receptor-type tyrosine-protein phosphatase S isoform X13

    UniProtKB/TrEMBL
    A0A0A0MR60
    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9491204
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9751204
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  15. XM_017027074.1XP_016882563.1  receptor-type tyrosine-protein phosphatase S isoform X11

  16. XM_017027067.1XP_016882556.1  receptor-type tyrosine-protein phosphatase S isoform X1

    UniProtKB/Swiss-Prot
    Q13332
  17. XM_011528157.2XP_011526459.1  receptor-type tyrosine-protein phosphatase S isoform X16

    Conserved Domains (8) summary
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:9611216
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:141225
    IG_like; Immunoglobulin like
    cd00047
    Location:9871216
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:32120
    Ig; Immunoglobulin domain
  18. XM_017027073.1XP_016882562.1  receptor-type tyrosine-protein phosphatase S isoform X10

  19. XM_011528158.2XP_011526460.1  receptor-type tyrosine-protein phosphatase S isoform X17

    Conserved Domains (3) summary
    smart00194
    Location:601856
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:627856
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:141238
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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