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Ptpn4 protein tyrosine phosphatase, non-receptor type 4 [ Mus musculus (house mouse) ]

Gene ID: 19258, updated on 22-Aug-2021

Summary

Official Symbol
Ptpn4provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 4provided by MGI
Primary source
MGI:MGI:1099792
See related
Ensembl:ENSMUSG00000026384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TE; TEP; PTPM; Ptn4; PTPMEG; hPTP-M; TEP/mPTP; hPTP-MEG; TEP/mPTPMEG
Expression
Broad expression in cerebellum adult (RPKM 7.2), frontal lobe adult (RPKM 5.7) and 22 other tissues See more
Orthologs
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Genomic context

See Ptpn4 in Genome Data Viewer
Location:
1 E2.3; 1 52.39 cM
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (119580197..119765281, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (119652467..119837585, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (121554669..121733648, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3830432H09 gene Neighboring gene predicted gene, 25322 Neighboring gene erythrocyte membrane protein band 4.1 like 5 Neighboring gene High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) Neighboring gene Acidic ribosomal phosphoprotein P0 pseudogene Neighboring gene predicted gene 29658 Neighboring gene predicted gene 3551

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 4
Names
testis-enriched protein tyrosine phosphatase
NP_064317.2
XP_006529316.1
XP_006529317.1
XP_006529318.1
XP_006529319.1
XP_030108159.1
XP_030108161.1
XP_030108162.1
XP_030108163.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019933.2NP_064317.2  tyrosine-protein phosphatase non-receptor type 4

    See identical proteins and their annotated locations for NP_064317.2

    Status: VALIDATED

    Source sequence(s)
    AC123955, AF106702, AK046683, AK166169, BE985496
    Consensus CDS
    CCDS15227.1
    UniProtKB/Swiss-Prot
    Q9WU22
    UniProtKB/TrEMBL
    Q8BQQ4
    Related
    ENSMUSP00000067614.6, ENSMUST00000064091.12
    Conserved Domains (8) summary
    smart00194
    Location:657910
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:30222
    B41; Band 4.1 homologues
    cd00047
    Location:682909
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:515602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam00373
    Location:115222
    FERM_M; FERM central domain
    pfam08736
    Location:325365
    FA; FERM adjacent (FA)
    pfam09379
    Location:3397
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    119580197..119765281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529253.5XP_006529316.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

    Conserved Domains (6) summary
    cd00992
    Location:500587
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:201295
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    cd17194
    Location:28111
    FERM_F1_PTPN4; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in tyrosine-protein phosphatase non-receptor type 4 (PTPN4)
    pfam00373
    Location:113207
    FERM_M; FERM central domain
    pfam08736
    Location:310350
    FA; FERM adjacent (FA)
    cl28904
    Location:626899
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_006529255.4XP_006529318.1  tyrosine-protein phosphatase non-receptor type 4 isoform X3

    Conserved Domains (6) summary
    smart00295
    Location:48171
    B41; Band 4.1 homologues
    cd00992
    Location:464551
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:165259
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:274314
    FA; FERM adjacent (FA)
    cl28904
    Location:590863
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    cl28922
    Location:177
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. XM_006529254.5XP_006529317.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

    Conserved Domains (6) summary
    smart00295
    Location:48186
    B41; Band 4.1 homologues
    cd00992
    Location:479566
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:180274
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:289329
    FA; FERM adjacent (FA)
    cl28904
    Location:605878
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    cl28922
    Location:177
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. XM_030252301.2XP_030108161.1  tyrosine-protein phosphatase non-receptor type 4 isoform X4

    Conserved Domains (4) summary
    cd00992
    Location:279366
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08736
    Location:89129
    FA; FERM adjacent (FA)
    cl17171
    Location:174
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:405678
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. XM_030252299.2XP_030108159.1  tyrosine-protein phosphatase non-receptor type 4 isoform X4

    Conserved Domains (4) summary
    cd00992
    Location:279366
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08736
    Location:89129
    FA; FERM adjacent (FA)
    cl17171
    Location:174
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:405678
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  6. XM_006529256.3XP_006529319.1  tyrosine-protein phosphatase non-receptor type 4 isoform X4

    Conserved Domains (4) summary
    cd00992
    Location:279366
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08736
    Location:89129
    FA; FERM adjacent (FA)
    cl17171
    Location:174
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:405678
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  7. XM_030252302.2XP_030108162.1  tyrosine-protein phosphatase non-receptor type 4 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:228315
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08736
    Location:3878
    FA; FERM adjacent (FA)
    cl17171
    Location:123
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:354627
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  8. XM_030252303.2XP_030108163.1  tyrosine-protein phosphatase non-receptor type 4 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:228315
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam08736
    Location:3878
    FA; FERM adjacent (FA)
    cl17171
    Location:123
    PH-like; Pleckstrin homology-like domain
    cl28904
    Location:354627
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_004941262.1 RNA Sequence

  2. XR_004941263.1 RNA Sequence

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