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PTPN4 protein tyrosine phosphatase non-receptor type 4 [ Homo sapiens (human) ]

Gene ID: 5775, updated on 21-Dec-2019

Summary

Official Symbol
PTPN4provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 4provided by HGNC
Primary source
HGNC:HGNC:9656
See related
Ensembl:ENSG00000088179 MIM:176878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEG; PTPMEG; PTPMEG1
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.2), brain (RPKM 5.8) and 24 other tissues See more
Orthologs

Genomic context

See PTPN4 in Genome Data Viewer
Location:
2q14.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (119759922..119984899)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120517207..120742496)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 177 Neighboring gene ribosomal protein L17 pseudogene 15 Neighboring gene uncharacterized LOC101927764 Neighboring gene Sharpr-MPRA regulatory region 5959 Neighboring gene uncharacterized LOC107985817 Neighboring gene ribosomal protein L27 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21893

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 4
Names
PTPase-MEG1
megakaryocyte phosphatase
megakaryocyte protein-tyrosine phosphatase
protein tyrosine phosphatase MEG1
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
NP_002821.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002830.4NP_002821.1  tyrosine-protein phosphatase non-receptor type 4

    See identical proteins and their annotated locations for NP_002821.1

    Status: REVIEWED

    Source sequence(s)
    AC016691, BC010674, M68941
    Consensus CDS
    CCDS2129.1
    UniProtKB/Swiss-Prot
    P29074
    UniProtKB/TrEMBL
    A0A024RAE8
    Related
    ENSP00000263708.2, ENST00000263708.7
    Conserved Domains (5) summary
    smart00295
    Location:30222
    B41; Band 4.1 homologues
    cd00047
    Location:682909
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:515602
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216310
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    pfam08736
    Location:325365
    FA; FERM adjacent (FA)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    119759922..119984899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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