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Ptpn13 protein tyrosine phosphatase, non-receptor type 13 [ Mus musculus (house mouse) ]

Gene ID: 19249, updated on 18-Apr-2024

Summary

Official Symbol
Ptpn13provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 13provided by MGI
Primary source
MGI:MGI:103293
See related
Ensembl:ENSMUSG00000034573 AllianceGenome:MGI:103293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIP; PTPL1; Ptpri; PTP-BL
Summary
Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; and regulation of phosphatidylinositol 3-kinase signaling. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including brain; epithelium; genitourinary system; gut; and humerus cartilage condensation. Orthologous to human PTPN13 (protein tyrosine phosphatase non-receptor type 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 15.0), ovary adult (RPKM 11.2) and 21 other tissues See more
Orthologs
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Genomic context

Location:
5 E5; 5 50.43 cM
Exon count:
48
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (103573058..103746227)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (103425192..103598361)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700021F02 gene Neighboring gene STARR-seq mESC enhancer starr_13776 Neighboring gene predicted gene, 30443 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 6 Neighboring gene RIKEN cDNA 1700016H13 gene Neighboring gene STARR-seq mESC enhancer starr_13780 Neighboring gene predicted gene, 42138

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol 3-kinase regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 13
Names
PTP36
protein tyrosine phosphatase DPZPTP
protein tyrosine phosphatase PTP-BL
protein-tyrosine phosphatase RIP
tyrosine phosphatase
NP_035334.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011204.2NP_035334.2  tyrosine-protein phosphatase non-receptor type 13

    See identical proteins and their annotated locations for NP_035334.2

    Status: VALIDATED

    Source sequence(s)
    AK014577, AK080313, AK161200, AK164471, CF553324, CK391553, CX202144, Z32740
    Consensus CDS
    CCDS39186.1
    UniProtKB/Swiss-Prot
    Q61494, Q62135, Q64499, Q64512
    UniProtKB/TrEMBL
    G5E8B1
    Related
    ENSMUSP00000048119.10, ENSMUST00000048957.11
    Conserved Domains (11) summary
    smart00194
    Location:21812433
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00228
    Location:14881578
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:566774
    B41; Band 4.1 homologues
    smart00750
    Location:3190
    KIND; kinase non-catalytic C-lobe domain
    cd00047
    Location:22072433
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:10821166
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:661774
    FERM_M; FERM central domain
    pfam06614
    Location:20672207
    Neuromodulin; Neuromodulin
    pfam09379
    Location:569631
    FERM_N; FERM N-terminal domain
    pfam16599
    Location:11681356
    PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
    cl17171
    Location:770870
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    103573058..103746227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)