1X5Q,1WHA,2UZC,1VJ6,2EDZ,2DMZ,2EHR,2DB5,2EEI,1UJU,2D92,1WF8


Conserved Protein Domain Family
PDZ

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smart00228: PDZ 
Click on image for an interactive view with Cn3D
Domain present in PSD-95, Dlg, and ZO-1/2.
Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.
Statistics
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PSSM-Id: 214570
Aligned: 296 rows
Threshold Bit Score: 32.736
Threshold Setting Gi: 17538778
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1X5Q_A         15 EELTLTILRQT--GGLGISIAGGKGstpykgDD------EGIFISRVSEEGPAARAG-VRVGDKLLEVNG-------VAL 78   human
Q64512       1490 FEVKLFKNSSG--LGFSFSREDNLI------PEqingsiVRVKKLFPGQPAAESGKIdVGDVILKVNGAP-------LKG 1554 house mouse
NP_502380       5 KMIEICIDMEEg-EPLGATPND------------------KLVITKIQAG-TISEGK-LRIGDQVKKVNG-------QNC 56   nematode
NP_212252     181 VMFDVLREKENitFKETVSLQDFLK------EIgp---wADLVIADVVSNSPAKIAG-MKPGDEIISIDN-------VIL 243  Borrelia burg...
YP_004203892   93 KSFDETISASF--EGIGAQVEEKD---------------GEILIVSPIKGSPAEKAG-IKPRDQIIKVNGk-----sVKG 149  Bacillus subt...
BAI87151      101 KQFSDSLDSSF--EGIGAEVGMED---------------GKIIIVSPFKKSPAEKAG-LKPNDEIISINGe-----sMAG 157  Bacillus subt...
BAA00577      235 EQFNTEMSLSL--EGIGAVLQMDD---------------DYTVINSMVAGGPAAKSKaISVGDKIVGVGQtgkpmvdVIG 297  Escherichia c...
CBW30031      241 KSFNESINLSL--EGIGTTLQSED---------------DEISIKSLVPGAPAERSKkLHPGDKIIGVGQatgdiedVVG 303  Haemophilus i...
NP_439078     197 tnWTFDPEKES--AFEALGIMPMRP------K-------IEMVLSKVVQNSPAEKAG-LQIGDKILKENL-------TAL 253  Haemophilus i...
EGJ02590      198 rhWAFEPDKED--PVSSLGIRPRGP------Q-------IEPVLENVQPNSAASKAG-LQAGDRIVKVDG-------QPL 254  Shigella dyse...
Q64512       1490 FEVKLFKNSSG--LGFSFSREDNLI------PEqingsiVRVKKLFPGQPAAESGKIdVGDVILKVNGAP-------LKG 1554 house mouse
NP_502380       5 KMIEICIDMEEg-EPLGATPND------------------KLVITKIQAG-TISEGK-LRIGDQVKKVNG-------QNC 56   nematode
NP_212252     181 VMFDVLREKENitFKETVSLQDFLK------EIgp---wADLVIADVVSNSPAKIAG-MKPGDEIISIDN-------VIL 243  Borrelia burg...
YP_004203892   93 KSFDETISASF--EGIGAQVEEKD---------------GEILIVSPIKGSPAEKAG-IKPRDQIIKVNGk-----sVKG 149  Bacillus subt...
BAI87151      101 KQFSDSLDSSF--EGIGAEVGMED---------------GKIIIVSPFKKSPAEKAG-LKPNDEIISINGe-----sMAG 157  Bacillus subt...
BAA00577      235 EQFNTEMSLSL--EGIGAVLQMDD---------------DYTVINSMVAGGPAAKSKaISVGDKIVGVGQtgkpmvdVIG 297  Escherichia c...
CBW30031      241 KSFNESINLSL--EGIGTTLQSED---------------DEISIKSLVPGAPAERSKkLHPGDKIIGVGQatgdiedVVG 303  Haemophilus i...
NP_439078     197 tnWTFDPEKES--AFEALGIMPMRP------K-------IEMVLSKVVQNSPAEKAG-LQIGDKILKENL-------TAL 253  Haemophilus i...
EGJ02590      198 rhWAFEPDKED--PVSSLGIRPRGP------Q-------IEPVLENVQPNSAASKAG-LQAGDRIVKVDG-------QPL 254  Shigella dyse...
1X5Q_A         79 QGAEHHEAVEALRGAGTAVQMRVWRES 105  human
Q64512       1555 LSQQDVISALRGTAPEVSLLLCRPAPG 1581 house mouse
NP_502380      57 KDCNDFFRALRFAAP--CAKIMVNRDE 81   nematode
NP_212252     244 KNKRDLDYFLKNLNSd-VVEIKFSRNG 269  Borrelia burgdorferi B31
YP_004203892  150 MNVNEAVALIRGKKg-tKVKLELNRAG 175  Bacillus subtilis BSn5
BAI87151      158 KDLNHAVLKIRGKKg-sSVSMKIQRPG 183  Bacillus subtilis subsp. natto BEST195
BAA00577      298 WRLDDVVALIKGPKg-sKVRQEILPAG 323  Escherichia coli str. K12 substr. W3110
CBW30031      304 WRLEDLVEKIKGKKg-tKVRLEIEPAK 329  Haemophilus influenzae 10810
NP_439078     254 -PWQDFIKQVEQg---eSFSIKVERNG 276  Haemophilus influenzae Rd KW20
EGJ02590      255 TQWVTFVMLVRDNPg-kSLALEIERQG 280  Shigella dysenteriae 155-74
Q64512       1555 LSQQDVISALRGTAPEVSLLLCRPAPG 1581 house mouse
NP_502380      57 KDCNDFFRALRFAAP--CAKIMVNRDE 81   nematode
NP_212252     244 KNKRDLDYFLKNLNSd-VVEIKFSRNG 269  Borrelia burgdorferi B31
YP_004203892  150 MNVNEAVALIRGKKg-tKVKLELNRAG 175  Bacillus subtilis BSn5
BAI87151      158 KDLNHAVLKIRGKKg-sSVSMKIQRPG 183  Bacillus subtilis subsp. natto BEST195
BAA00577      298 WRLDDVVALIKGPKg-sKVRQEILPAG 323  Escherichia coli str. K12 substr. W3110
CBW30031      304 WRLEDLVEKIKGKKg-tKVRLEIEPAK 329  Haemophilus influenzae 10810
NP_439078     254 -PWQDFIKQVEQg---eSFSIKVERNG 276  Haemophilus influenzae Rd KW20
EGJ02590      255 TQWVTFVMLVRDNPg-kSLALEIERQG 280  Shigella dysenteriae 155-74
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