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Naip1 NLR family, apoptosis inhibitory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17940, updated on 8-Feb-2024

Summary

Official Symbol
Naip1provided by MGI
Official Full Name
NLR family, apoptosis inhibitory protein 1provided by MGI
Primary source
MGI:MGI:1298223
See related
Ensembl:ENSMUSG00000021640 AllianceGenome:MGI:1298223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naip; Birc1a; D13Lsd1; Naip-rs1
Summary
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within cellular response to estrogen stimulus and negative regulation of apoptotic process. Located in basolateral plasma membrane and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 14.0), colon adult (RPKM 12.4) and 2 other tissues See more
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Genomic context

See Naip1 in Genome Data Viewer
Location:
13 D1; 13 53.18 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100544272..100589372, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100407770..100452864, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NLR family, apoptosis inhibitory protein 3 Neighboring gene ubiquitin specific peptidase 38 pseudogene Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene general transcription factor II H, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E1467 Neighboring gene occludin Neighboring gene predicted gene, 57598

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to estrogen stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_negative_effect regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of IPAF inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 1a
Names
baculoviral IAP repeat-containing 1a
neuronal apoptosis inhibitory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008670.2NP_032696.2  baculoviral IAP repeat-containing protein 1a

    See identical proteins and their annotated locations for NP_032696.2

    Status: VALIDATED

    Source sequence(s)
    AF007769, AF135491
    Consensus CDS
    CCDS26729.1
    UniProtKB/Swiss-Prot
    A2RT89, Q9JIB5, Q9QWK5, Q9R017
    Related
    ENSMUSP00000152583.2, ENSMUST00000222155.2
    Conserved Domains (6) summary
    cd09293
    Location:10721191
    AMN1; Antagonist of mitotic exit network protein 1
    smart00238
    Location:159229
    BIR; Baculoviral inhibition of apoptosis protein repeat
    smart00382
    Location:465600
    AAA; ATPases associated with a variety of cellular activities
    cd00022
    Location:279346
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00034
    Location:11321156
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:464617
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100544272..100589372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157898.1XP_036013791.1  baculoviral IAP repeat-containing protein 1a isoform X1

    Conserved Domains (6) summary
    cd09293
    Location:808927
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:868892
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00653
    Location:1782
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:200353
    NACHT; NACHT domain
    pfam17779
    Location:423478
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:502608
    NLRC4_HD; NLRC4 helical domain