1G73,1QBH,1C9Q,1JD6,1E31


Conserved Protein Domain Family
BIR

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cd00022: BIR 
Click on image for an interactive view with Cn3D
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.
Statistics
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PSSM-Id: 237989
View PSSM: cd00022
Aligned: 64 rows
Threshold Bit Score: 66.5203
Threshold Setting Gi: 9631408
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn2+ bindingpeptide binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
Feature 1                                              #  #                 #      #     
1G73_C       29 EARIFTFGTWIy-----sVNKEQLARAGFYALGegDKVKCFHCGGGLTd-WKPSEDPWEQHAKWYPGCKYLLE 95
1QBH_A        8 AARMRTFMYWPss---vpVQPEQLASAGFYYVGrnDDVKCFCCDGGLRc-WESGDDPWVEHAKWFPRCEFLIR 76
gi 9631106    5 RRRLASFRNWSav---daPAPAELAHAGFYCANrqDFVKCAYCHIEIGn-WSIGSDAMSDHKRYSPACRFVCE 73
gi 11068101  10 ESRVESFKYYEr-----nVDVRKLSLLGFYYSGhqDQIICAYCNLTLDr-FTGDEDVQTDHRRFSPHCPIIYD 76
gi 14602353 106 EHRINSFQNFPas---lkSLVSDLSANGFYYTNigDAVCCYACLIIAKd-WTMNSDVRQIHVRLNARCPLLQL 174
gi 14602353   5 ENRLNSFKYWPg-----hEDKEKLALMGFYFSGmgDQIVCHYCKLDLYnfATGAEDSVRDHKRYSPHCPFLLN 72
gi 18138391  87 YLRRDSFRQYKkaksyfkNSLDLLAQNGFYYYGvkTEVRCAYCLLVIVk-FNFNDNLADIHRINSIDCIFVND 158
gi 20069989  87 TLRKESFRKFKiarahfkDNYQQLAQNGFYYYGkkVEIRCSCCQIVIVk-LNKTDNASVIHRTWSPECHFNTL 158
gi 9631046   83 RRRAASFRAFKagcgkygSDANALAACGFFYNGrcREAQCSRCGMVVVk-LQRGDDLNYIHGVYSPRCAFVVK 154
gi 2497247   30 DARNQSFAIHDi------KNYEKFSNAGLFYTSp-TEITCYCCGMKFCn-WLYEKHPLQVHGFWSRNCGFMRA 94

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