5YUD


Conserved Protein Domain Family
NLRC4_HD
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pfam17889: NLRC4_HD (this model, PSSM-Id:407744 is obsolete and has been replaced by 436120)
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NLRC4 helical domain
This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in mouse NLR family CARD domain-containing protein 4. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).
Links
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Statistics
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PSSM-Id: 407744
Aligned: 23 rows
Threshold Bit Score: 108.134
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5YUD_A        767 EDQDLGLYYLRQIDSPLKAINSFNIFLYYvSSHSSSKAAPTVVSHLLQLVDEkESLENMS---------ENEDYMKLHPQ 837  house mouse
XP_015219365  765 AEREKSQNDLKRIDSVAKFVY-FKLFLLF-TCTMSQTAATVIVDFVLNKLNRnTDS-------------RADEVINKYPE 829  spotted gar
F1M649        465 EEVSKGNSYLKKMVSISDITSLYGNLLLY-TCGSSTEATRAIMRHLAMVCEH-GSLQGLSvtkrplwrqESIQNLRNTTE 542  Norway rat
XP_003908534  465 EEVTKGNGYLQKMVSISDITSTYSSLLRY-TCGSSVEATRAVMKHLAAVYQH-GCLLGLSitkrplwrqESLQSVKNTTE 542  olive baboon
XP_005600137  465 EEVTKGNSHLQKMAFISDITSKYSNLLLY-TCGSSAEATRTVLRHLAAVCQH-GSLHGLSitkrplwrqESKENVKNTTV 542  horse
KFR06549      535 EKLERGLQYLQQINTFRKVAGRYNFLLAY-TCSFSSKAVPQIISYLFKLIDCkESLESQS---------EDDEHLQHHSD 604  crested ibis
XP_008101181  768 EDVDRGLQYLQQINTFVKISGRYQYILRY-ACVEASKAVPQIVTHLLSLPSCeKSFESQI---------KNDLYLQQTPE 837  green anole
XP_013011477  465 EEVAKGNAYLQKMVCISDITSLYSNLLLY-TCGSSAAATRAVLRHLTGVCQH-GSLDGLSvtrrplwrqASIQSMNNTTD 542  domestic guin...
XP_003470303  765 EDQDLGLYYLKQINSPLLAVCSYHDFLKYvSSYPSTKVGPKMVSHLLHLASK-ESLGHPP---------PNSDPSKQEEE 834  domestic guin...
EHB15041      748 EDQDLGLYYLKQINSPMLAVSSYYNFLKYvCSYSSTKVGPNIVSHLLHLADSkESLEYLP---------RNGDSLKHEEE 818  naked mole-rat

5YUD_A        838 TFLWFQ-FVRGLWLVSPESSSSFVSEHLLRLALIFAY 873  house mouse
XP_015219365  830 TTDMNNhIIQFLYEF-PECRDSSVDTYLLNEVLDVLY 865  spotted gar
F1M649        543 QDVLKAiNVNSFVECGINLFSESISKSELSQEFEAFF 579  Norway rat
XP_003908534  543 QEILKAiNINSFVECGIHLYHESTSKSALSQEFEAFF 579  olive baboon
XP_005600137  543 QETLKAiNINSFTECGINLFHESRFESALSEEFEAFF 579  horse
KFR06549      605 LPIRML-FIDQLSSINPKLLLPVFMQYLLGFATSVAY 640  crested ibis
XP_008101181  838 LKLRQQeLLSVTLTLFPEVYLSTFSDFVLELVTELAY 874  green anole
XP_013011477  543 QEILKAiNINSFAECGINLFQESVSKSTLSHEFETFF 579  domestic guinea pig
XP_003470303  835 MSLDAQ-MFRSLWQLCPEQCLLLLSEFLLDFALSIAY 870  domestic guinea pig
EHB15041      819 MPLDTQ-AIRLLWQLCPEQCFLLLSEFLLDFALMIAY 854  naked mole-rat
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