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Myo10 myosin X [ Mus musculus (house mouse) ]

Gene ID: 17909, updated on 12-May-2024

Summary

Official Symbol
Myo10provided by MGI
Official Full Name
myosin Xprovided by MGI
Primary source
MGI:MGI:107716
See related
Ensembl:ENSMUSG00000022272 AllianceGenome:MGI:107716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
myosin-X; mKIAA0799; D15Ertd600e
Summary
Predicted to enable actin filament binding activity and spectrin binding activity. Acts upstream of or within positive regulation of cell-cell adhesion. Located in filopodium; neuron projection; and neuronal cell body. Is expressed in several structures, including autopod; central nervous system; genitourinary system; gut; and integumental system placode. Orthologous to human MYO10 (myosin X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 20.6), ovary adult (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Myo10 in Genome Data Viewer
Location:
15 B1; 15 9.36 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (25622636..25813759)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (25622550..25813673)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5468 Neighboring gene STARR-seq mESC enhancer starr_38167 Neighboring gene STARR-seq mESC enhancer starr_38168 Neighboring gene STARR-positive B cell enhancer mm9_chr15:25551922-25552223 Neighboring gene predicted gene, 36642 Neighboring gene STARR-seq mESC enhancer starr_38176 Neighboring gene PCNA-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_38182 Neighboring gene STARR-seq mESC enhancer starr_38185 Neighboring gene STARR-seq mESC enhancer starr_38189 Neighboring gene reticulophagy regulator 1 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 15_175.1 Neighboring gene STARR-seq mESC enhancer starr_38200 Neighboring gene microRNA 7212

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Spontaneous (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables plus-end directed microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell motility IC
Inferred by Curator
more info
PubMed 
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
unconventional myosin-X
Names
unconventional myosin-10
unconventionnal myosin-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353141.1NP_001340070.1  unconventional myosin-X isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC131178
    UniProtKB/TrEMBL
    Q80TR9
    Conserved Domains (8) summary
    smart00139
    Location:9111057
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10661320
    B41; Band 4.1 homologues
    cd13202
    Location:13161404
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:577678
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:743868
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cl17171
    Location:543585
    PH-like; Pleckstrin homology-like domain
    cl22853
    Location:285
    Motor_domain; Myosin and Kinesin motor domain
    cl27381
    Location:3334
    Myosin_head; Myosin head (motor domain)
  2. NM_001353142.1NP_001340071.1  unconventional myosin-X isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK122371
    Consensus CDS
    CCDS88740.1
    UniProtKB/TrEMBL
    E9Q5G1, Q80TR9
    Related
    ENSMUSP00000022882.6, ENSMUST00000022882.12
    Conserved Domains (10) summary
    smart00139
    Location:807953
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:9621216
    B41; Band 4.1 homologues
    cd13202
    Location:12121300
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:473574
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:639764
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    TIGR02168
    Location:94235
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd17206
    Location:9551050
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    pfam16735
    Location:136186
    MYO10_CC; Unconventional myosin-X coiled coil domain
    NF033609
    Location:243426
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl17171
    Location:439481
    PH-like; Pleckstrin homology-like domain
  3. NM_019472.2NP_062345.2  unconventional myosin-X isoform 1

    See identical proteins and their annotated locations for NP_062345.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK028552, AK089482, AK122371
    Consensus CDS
    CCDS37049.1
    UniProtKB/Swiss-Prot
    F8VQB6, Q8R3S0, Q9JJY5
    Related
    ENSMUSP00000106087.2, ENSMUST00000110457.8
    Conserved Domains (15) summary
    smart00015
    Location:741763
    IQ; Calmodulin-binding motif
    smart00139
    Location:15531699
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:58739
    MYSc; Myosin. Large ATPases
    smart00295
    Location:17081962
    B41; Band 4.1 homologues
    cd13202
    Location:19582046
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:12191320
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:13851510
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd14873
    Location:77727
    MYSc_Myo10; class X myosin, motor domain
    pfam00169
    Location:12191314
    PH; PH domain
    pfam00373
    Location:18031962
    FERM_M; FERM central domain
    pfam15346
    Location:796939
    ARGLU; Arginine and glutamate-rich 1
    pfam16735
    Location:882932
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl00155
    Location:17051750
    UBQ; Ubiquitin-like proteins
    cl02488
    Location:843957
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:11851227
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    25622636..25813759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248368.2XP_030104228.1  unconventional myosin-X isoform X1

    UniProtKB/TrEMBL
    Q80TR9
    Conserved Domains (9) summary
    smart00139
    Location:9101056
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10651319
    B41; Band 4.1 homologues
    COG5022
    Location:2333
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:13151403
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:576677
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:742867
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:10581153
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    cl22853
    Location:184
    Motor_domain; Myosin and Kinesin motor domain
    cl17171
    Location:542584
    PH-like; Pleckstrin homology-like domain
  2. XM_030248369.1XP_030104229.1  unconventional myosin-X isoform X1

    UniProtKB/TrEMBL
    Q80TR9
    Conserved Domains (9) summary
    smart00139
    Location:9101056
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10651319
    B41; Band 4.1 homologues
    COG5022
    Location:2333
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:13151403
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:576677
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:742867
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:10581153
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    cl22853
    Location:184
    Motor_domain; Myosin and Kinesin motor domain
    cl17171
    Location:542584
    PH-like; Pleckstrin homology-like domain
  3. XM_036159219.1XP_036015112.1  unconventional myosin-X isoform X3

    UniProtKB/TrEMBL
    E9Q5G1, Q80TR9
    Conserved Domains (10) summary
    smart00139
    Location:807953
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:9621216
    B41; Band 4.1 homologues
    cd13202
    Location:12121300
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:473574
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:639764
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    TIGR02168
    Location:94235
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd17206
    Location:9551050
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    pfam16735
    Location:136186
    MYO10_CC; Unconventional myosin-X coiled coil domain
    NF033609
    Location:243426
    MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA
    cl17171
    Location:439481
    PH-like; Pleckstrin homology-like domain
  4. XM_006520025.5XP_006520088.1  unconventional myosin-X isoform X1

    UniProtKB/TrEMBL
    Q80TR9
    Conserved Domains (9) summary
    smart00139
    Location:9101056
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10651319
    B41; Band 4.1 homologues
    COG5022
    Location:2333
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:13151403
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:576677
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:742867
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:10581153
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    cl22853
    Location:184
    Motor_domain; Myosin and Kinesin motor domain
    cl17171
    Location:542584
    PH-like; Pleckstrin homology-like domain
  5. XM_006520026.5XP_006520089.1  unconventional myosin-X isoform X2

    UniProtKB/TrEMBL
    Q80TR9
    Conserved Domains (10) summary
    smart00139
    Location:831977
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:9861240
    B41; Band 4.1 homologues
    COG4372
    Location:5232
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd13202
    Location:12361324
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:497598
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:663788
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    TIGR02680
    Location:122259
    TIGR02680; TIGR02680 family protein
    cd17206
    Location:9791074
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    pfam16735
    Location:160210
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl17171
    Location:463505
    PH-like; Pleckstrin homology-like domain