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MYO10 myosin X [ Homo sapiens (human) ]

Gene ID: 4651, updated on 1-Jun-2020

Summary

Official Symbol
MYO10provided by HGNC
Official Full Name
myosin Xprovided by HGNC
Primary source
HGNC:HGNC:7593
See related
Ensembl:ENSG00000145555 MIM:601481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
Expression
Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues See more
Orthologs

Genomic context

See MYO10 in Genome Data Viewer
Location:
5p15.1
Exon count:
44
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (16661907..16936288, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16662016..16936385, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 622 Neighboring gene reticulophagy regulator 1 Neighboring gene uncharacterized LOC101929524 Neighboring gene RNA, 5S ribosomal pseudogene 179 Neighboring gene ribosomal protein S26 pseudogene 28 Neighboring gene RNA, U6 small nuclear 660, pseudogene Neighboring gene BASP1 antisense RNA 1 Neighboring gene microRNA 10522

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10639, FLJ21066, FLJ22268, FLJ43256, KIAA0799, MGC131988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin-dependent ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
plus-end directed microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
spectrin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
cytoskeleton-dependent intracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
filopodium membrane IEA
Inferred from Electronic Annotation
more info
 
filopodium tip ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
myosin complex IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
unconventional myosin-X
Names
unconventional myosin-10
unconventionnal myosin-X

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012334.3NP_036466.2  unconventional myosin-X

    See identical proteins and their annotated locations for NP_036466.2

    Status: REVIEWED

    Source sequence(s)
    AC010607, AC024588, AF234532, AI086647, BC014956, BC150285, CA488271, DA504301
    Consensus CDS
    CCDS54834.1
    UniProtKB/Swiss-Prot
    Q9HD67
    Related
    ENSP00000421280.1, ENST00000513610.6
    Conserved Domains (12) summary
    smart00139
    Location:15491695
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:58739
    MYSc; Myosin. Large ATPases
    smart00295
    Location:17041958
    B41; Band 4.1 homologues
    cd13202
    Location:19542042
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:12151316
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:13811506
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd14873
    Location:77727
    MYSc_Myo10; class X myosin, motor domain
    pfam00169
    Location:12151308
    PH; PH domain
    pfam00373
    Location:17961958
    FERM_M; FERM central domain
    pfam16735
    Location:883933
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl00155
    Location:17051753
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:11811223
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    16661907..16936288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714475.3XP_006714538.1  unconventional myosin-X isoform X1

    Conserved Domains (12) summary
    smart00139
    Location:15261672
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:58716
    MYSc; Myosin. Large ATPases
    smart00295
    Location:16811935
    B41; Band 4.1 homologues
    cd13202
    Location:19312019
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:11921293
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:13581483
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd14873
    Location:77704
    MYSc_Myo10; class X myosin, motor domain
    pfam00169
    Location:11921285
    PH; PH domain
    pfam00373
    Location:17731935
    FERM_M; FERM central domain
    pfam16735
    Location:860910
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl00155
    Location:16821730
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:11581200
    PH-like; Pleckstrin homology-like domain
  2. XM_005248307.2XP_005248364.1  unconventional myosin-X isoform X3

    See identical proteins and their annotated locations for XP_005248364.1

    UniProtKB/Swiss-Prot
    Q9HD67
    Related
    ENSP00000421170.1, ENST00000505695.5
    Conserved Domains (11) summary
    smart00139
    Location:9061052
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10611315
    B41; Band 4.1 homologues
    cd13202
    Location:13111399
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:572673
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:738863
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cl22853
    Location:184
    Motor_domain; Myosin and Kinesin motor domain
    pfam00169
    Location:572665
    PH; PH domain
    pfam00373
    Location:11531315
    FERM_M; FERM central domain
    pfam16735
    Location:240290
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl00155
    Location:10621110
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:538580
    PH-like; Pleckstrin homology-like domain
  3. XM_011514046.2XP_011512348.1  unconventional myosin-X isoform X3

    See identical proteins and their annotated locations for XP_011512348.1

    UniProtKB/Swiss-Prot
    Q9HD67
    Related
    ENSP00000425051.1, ENST00000515803.5
    Conserved Domains (11) summary
    smart00139
    Location:9061052
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10611315
    B41; Band 4.1 homologues
    cd13202
    Location:13111399
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:572673
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:738863
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cl22853
    Location:184
    Motor_domain; Myosin and Kinesin motor domain
    pfam00169
    Location:572665
    PH; PH domain
    pfam00373
    Location:11531315
    FERM_M; FERM central domain
    pfam16735
    Location:240290
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl00155
    Location:10621110
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:538580
    PH-like; Pleckstrin homology-like domain
  4. XM_005248306.4XP_005248363.1  unconventional myosin-X isoform X2

    Conserved Domains (11) summary
    smart00139
    Location:9071053
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10621316
    B41; Band 4.1 homologues
    cd13202
    Location:13121400
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:573674
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:739864
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cl22853
    Location:285
    Motor_domain; Myosin and Kinesin motor domain
    pfam00169
    Location:573666
    PH; PH domain
    pfam00373
    Location:11541316
    FERM_M; FERM central domain
    pfam16735
    Location:241291
    MYO10_CC; Unconventional myosin-X coiled coil domain
    cl00155
    Location:10631111
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:539581
    PH-like; Pleckstrin homology-like domain
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