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DLG1 discs large MAGUK scaffold protein 1 [ Homo sapiens (human) ]

Gene ID: 1739, updated on 7-Jun-2020

Summary

Official Symbol
DLG1provided by HGNC
Official Full Name
discs large MAGUK scaffold protein 1provided by HGNC
Primary source
HGNC:HGNC:2900
See related
Ensembl:ENSG00000075711 MIM:601014
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hdlg; DLGH1; SAP97; SAP-97
Summary
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]
Expression
Ubiquitous expression in thyroid (RPKM 13.8), brain (RPKM 11.7) and 25 other tissues See more
Orthologs

Genomic context

See DLG1 in Genome Data Viewer
Location:
3q29
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (197042560..197299321, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196769431..197026171, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MELTF antisense RNA 1 Neighboring gene ribosomal protein SA pseudogene 30 Neighboring gene melanotransferrin Neighboring gene DLG1 antisense RNA 1 Neighboring gene microRNA 4797 Neighboring gene uncharacterized LOC101926923 Neighboring gene uncharacterized LOC105374308

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env DLG1 knockdown enhances the amount of Env in producer cells and virions. DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures PubMed
Pr55(Gag) gag DLG1 knockdown is associated with the redistribution and colocalization of Gag toward CD63 and CD82 positive vesicle-like structures PubMed
gag Endogenous DLG1 interacts with HIV-1 Gag in HIV-1-infected T cells. The NC domain of Gag is required for the interaction with DLG1 PubMed
nucleocapsid gag Endogenous DLG1 interacts with HIV-1 Gag in HIV-1-infected T cells. The NC domain of Gag is required for the interaction with DLG1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761P0818, DKFZp781B0426

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L27 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
cytoskeletal protein binding TAS
Traceable Author Statement
more info
PubMed 
guanylate kinase activity TAS
Traceable Author Statement
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
potassium channel regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GDP metabolic process IEA
Inferred from Electronic Annotation
more info
 
GMP metabolic process IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
T cell activation IEA
Inferred from Electronic Annotation
more info
 
T cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
amyloid precursor protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bicellular tight junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
cortical microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
establishment of centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
establishment or maintenance of epithelial cell apical/basal polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hard palate development IEA
Inferred from Electronic Annotation
more info
 
immunological synapse formation IEA
Inferred from Electronic Annotation
more info
 
lens development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
 
membrane raft organization IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter receptor localization to postsynaptic specialization membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peristalsis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane TAS
Traceable Author Statement
more info
PubMed 
receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor localization to synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of NMDA receptor activity TAS
Traceable Author Statement
more info
 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion export across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of potassium ion import ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of protein localization to synapse IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sodium ion transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ventricular cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
reproductive structure development IEA
Inferred from Electronic Annotation
more info
 
smooth muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
MPP7-DLG1-LIN7 complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basement membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
immunological synapse TAS
Traceable Author Statement
more info
PubMed 
intercalated disc TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with ionotropic glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral loop IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath abaxonal region IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
node of Ranvier IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
disks large homolog 1
Names
dJ1061C18.1.1
discs large homolog 1, scribble cell polarity complex component
presynaptic protein SAP97
synapse-associated protein 97

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029099.1 RefSeqGene

    Range
    5001..261017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098424.1NP_001091894.1  disks large homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_001091894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC068302, AC092937, U13897
    Consensus CDS
    CCDS43194.1
    UniProtKB/Swiss-Prot
    Q12959
    Related
    ENSP00000391732.2, ENST00000448528.6
    Conserved Domains (7) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:713891
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  2. NM_001204386.1NP_001191315.1  disks large homolog 1 isoform 3

    See identical proteins and their annotated locations for NP_001191315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing an in-frame coding exon, and contains an alternate in-frame coding exon compared to variant 1. This results in a shorter isoform (3) compared to isoform 1.
    Source sequence(s)
    AA837080, AC068302, AI223994, AK293967, BC042118, BC144651, BM728664, EF553524, U13897
    Consensus CDS
    CCDS75072.1
    UniProtKB/Swiss-Prot
    Q12959
    UniProtKB/TrEMBL
    A0A0C4DFT3, B4DF78
    Related
    ENSP00000499584.1, ENST00000656944.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:701879
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  3. NM_001204387.1NP_001191316.1  disks large homolog 1 isoform 4

    See identical proteins and their annotated locations for NP_001191316.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, missing an in-frame coding exon, and contains an additional in-frame coding exon compared to variant 1. This results in a shorter isoform (4) with an unique N-terminus compared to isoform 1.
    Source sequence(s)
    AA837080, AC068302, AI223994, AK293967, AK294772, AK294855, BC042118, BM728664, EF553524
    Consensus CDS
    CCDS56301.1
    UniProtKB/Swiss-Prot
    Q12959
    UniProtKB/TrEMBL
    B4DF78
    Related
    ENSP00000396658.1, ENST00000443183.5
    Conserved Domains (6) summary
    cd12031
    Location:466532
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:347431
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:108192
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:609787
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:288349
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:75107
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  4. NM_001204388.1NP_001191317.1  disks large homolog 1 isoform 5

    See identical proteins and their annotated locations for NP_001191317.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon and is missing an in-frame coding exon compared to variant 1. This results in a shorter isoform (5) with an unique N-terminus compared to isoform 1.
    Source sequence(s)
    AA837080, AC068302, AI223994, AK294855, BC042118, BC144651, BM728664, EF553524
    Consensus CDS
    CCDS56300.1
    UniProtKB/Swiss-Prot
    Q12959
    Related
    ENSP00000398939.1, ENST00000452595.5
    Conserved Domains (6) summary
    cd12031
    Location:466532
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:347431
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:108192
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:597775
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:288349
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:75107
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  5. NM_001290983.1NP_001277912.1  disks large homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_001277912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Both variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AA837080, AC068302, EF553524, U13897
    Consensus CDS
    CCDS43194.1
    UniProtKB/Swiss-Prot
    Q12959
    Related
    ENSP00000407531.1, ENST00000419354.5
    Conserved Domains (7) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:713891
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  6. NM_001363865.1NP_001350794.1  disks large homolog 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Consensus CDS
    CCDS87192.1
    Related
    ENSP00000350303.6, ENST00000357674.9
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:702880
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  7. NM_001366203.1NP_001353132.1  disks large homolog 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499313.1, ENST00000667104.1
    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:674852
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  8. NM_001366204.1NP_001353133.1  disks large homolog 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499602.1, ENST00000659716.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:680858
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  9. NM_001366205.1NP_001353134.1  disks large homolog 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499507.1, ENST00000657381.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:701879
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  10. NM_001366206.1NP_001353135.1  disks large homolog 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499229.1, ENST00000661336.1
    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:684862
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  11. NM_001366207.1NP_001353136.1  disks large homolog 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499414.1, ENST00000667157.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:702880
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  12. NM_001366208.1NP_001353137.1  disks large homolog 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499657.1, ENST00000655488.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:680858
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  13. NM_001366209.1NP_001353138.1  disks large homolog 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499580.1, ENST00000671185.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:680858
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  14. NM_001366210.1NP_001353139.1  disks large homolog 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499413.1, ENST00000669565.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:702880
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  15. NM_001366211.1NP_001353140.1  disks large homolog 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499723.1, ENST00000656087.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:692870
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  16. NM_001366212.1NP_001353141.1  disks large homolog 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499514.1, ENST00000661453.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:680858
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  17. NM_001366213.1NP_001353142.1  disks large homolog 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499269.1, ENST00000659221.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:701879
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  18. NM_001366214.1NP_001353143.1  disks large homolog 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499363.1, ENST00000660898.1
    Conserved Domains (7) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:734912
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  19. NM_001366215.1NP_001353144.1  disks large homolog 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499542.1, ENST00000670455.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:702880
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  20. NM_001366216.1NP_001353145.1  disks large homolog 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000413238.1, ENST00000422288.6
    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:662840
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  21. NM_001366217.1NP_001353146.1  disks large homolog 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499774.1, ENST00000662727.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:692870
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  22. NM_001366218.1NP_001353147.1  disks large homolog 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499437.1, ENST00000670935.1
    Conserved Domains (7) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:713891
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  23. NM_001366219.1NP_001353148.1  disks large homolog 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499793.1, ENST00000666007.1
    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:662840
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  24. NM_001366220.1NP_001353149.1  disks large homolog 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:683861
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  25. NM_001366221.1NP_001353150.1  disks large homolog 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499599.1, ENST00000653795.1
    Conserved Domains (6) summary
    cd12031
    Location:499565
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:380464
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:141225
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:642820
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:321382
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:110140
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  26. NM_001366222.1NP_001353151.1  disks large homolog 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENSP00000499692.1, ENST00000671246.1
    Conserved Domains (6) summary
    cd12031
    Location:499565
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:380464
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:141225
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:630808
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:321382
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:110140
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  27. NM_004087.2NP_004078.2  disks large homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_004078.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1, resulting in a longer isoform (2) compared to isoform 1.
    Source sequence(s)
    AC068302, AC092937, U13896
    Consensus CDS
    CCDS3327.1
    UniProtKB/Swiss-Prot
    Q12959
    Related
    ENSP00000345731.2, ENST00000346964.6
    Conserved Domains (8) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:746913
    GuKc; Guanylate kinase homologues
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:735913
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RNA

  1. NR_158764.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
  2. NR_158765.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENST00000664564.1
  3. NR_158766.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
  4. NR_158767.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC068302, AC092937
    Related
    ENST00000653331.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    197042560..197299321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005813.1XP_016861302.1  disks large homolog 1 isoform X6

    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:684862
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  2. XM_017005801.1XP_016861290.1  disks large homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q12959
    Conserved Domains (8) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:746913
    GuKc; Guanylate kinase homologues
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:735913
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  3. XM_017005800.1XP_016861289.1  disks large homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q12959
    Conserved Domains (8) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:746913
    GuKc; Guanylate kinase homologues
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:735913
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  4. XM_017005811.2XP_016861300.1  disks large homolog 1 isoform X6

    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:684862
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  5. XM_005269289.4XP_005269346.1  disks large homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_005269346.1

    UniProtKB/Swiss-Prot
    Q12959
    Conserved Domains (8) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:746913
    GuKc; Guanylate kinase homologues
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:735913
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  6. XM_017005812.1XP_016861301.1  disks large homolog 1 isoform X6

    Conserved Domains (7) summary
    cd12031
    Location:531597
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:412496
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:173257
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:684862
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:353414
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106172
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  7. XM_017005802.1XP_016861291.1  disks large homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q12959
    Conserved Domains (8) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:746913
    GuKc; Guanylate kinase homologues
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:735913
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  8. XM_017005821.2XP_016861310.1  disks large homolog 1 isoform X10

    Conserved Domains (7) summary
    cd12031
    Location:499565
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:663830
    GuKc; Guanylate kinase homologues
    smart00228
    Location:380464
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:141225
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:652830
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:321382
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:102140
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  9. XM_017005823.2XP_016861312.1  disks large homolog 1 isoform X12

  10. XM_017005824.2XP_016861313.1  disks large homolog 1 isoform X13

  11. XM_017005819.1XP_016861308.1  disks large homolog 1 isoform X8

    UniProtKB/Swiss-Prot
    Q12959
    Related
    ENSP00000499384.1, ENST00000663148.1
    Conserved Domains (7) summary
    cd12031
    Location:549615
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:680858
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  12. XM_017005803.1XP_016861292.1  disks large homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q12959
    Conserved Domains (8) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00072
    Location:746913
    GuKc; Guanylate kinase homologues
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:735913
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  13. XM_011512502.3XP_011510804.1  disks large homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_011510804.1

    UniProtKB/Swiss-Prot
    Q12959
    Conserved Domains (7) summary
    cd12031
    Location:582648
    SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1
    smart00228
    Location:463547
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:224308
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:713891
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:404465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106223
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
  14. XM_011512509.2XP_011510811.1  disks large homolog 1 isoform X14

    Related
    ENSP00000376186.3, ENST00000392381.7
    Conserved Domains (5) summary
    smart00228
    Location:430514
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:191275
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09058
    Location:462
    L27_1; L27_1
    pfam10600
    Location:371432
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:106190
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RNA

  1. XR_001740040.2 RNA Sequence

  2. XR_001740044.2 RNA Sequence

  3. XR_001740043.2 RNA Sequence

    Related
    ENST00000660432.1
  4. XR_001740039.2 RNA Sequence

  5. XR_001740036.2 RNA Sequence

  6. XR_001740037.2 RNA Sequence

  7. XR_001740038.2 RNA Sequence

  8. XR_924108.3 RNA Sequence

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