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ZNF467 zinc finger protein 467 [ Homo sapiens (human) ]

Gene ID: 168544, updated on 11-Jun-2021

Summary

Official Symbol
ZNF467provided by HGNC
Official Full Name
zinc finger protein 467provided by HGNC
Primary source
HGNC:HGNC:23154
See related
Ensembl:ENSG00000181444 MIM:614040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZI; Zfp467
Summary
The protein encoded by this gene is a zinc finger protein whose function has not yet been elucidated in humans. However, the mouse ortholog of this protein enhances adipocyte differentiation and suppresses osteoblast differentiation in bone marrow. The mouse protein also is a transcription factor for several genes and can help recruit histone deacetylase complexes. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in spleen (RPKM 2.9), kidney (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF467 in Genome Data Viewer
Location:
7q36.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (149764182..149776323, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149461271..149470677, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tRNA-Cys (anticodon GCA) 9-4 Neighboring gene KRAB-A domain containing 1 Neighboring gene SCO-spondin, pseudogene Neighboring gene zinc finger protein 862 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene ATPase H+ transporting V0 subunit e2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 467
Names
zinc finger protein EZI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329856.2NP_001316785.1  zinc finger protein 467 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004877, BC038972, CV575107
    Consensus CDS
    CCDS87563.1
    UniProtKB/TrEMBL
    C9JAX3
    Related
    ENSP00000418011.1, ENST00000484747.5
  2. NM_207336.3NP_997219.1  zinc finger protein 467 isoform 1

    See identical proteins and their annotated locations for NP_997219.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004877, BC038972, BC052625, CV575107
    Consensus CDS
    CCDS5899.1
    UniProtKB/Swiss-Prot
    Q7Z7K2
    Related
    ENSP00000304769.3, ENST00000302017.4
    Conserved Domains (2) summary
    COG5048
    Location:190565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218238
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    149764182..149776323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515858.1XP_011514160.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_011514160.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218238
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017011799.2XP_016867288.1  zinc finger protein 467 isoform X2

  3. XM_011515857.3XP_011514159.1  zinc finger protein 467 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:404779
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:432452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:430452
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:444469
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006715864.4XP_006715927.1  zinc finger protein 467 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:231606
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:257279
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:271296
    zf-H2C2_2; Zinc-finger double domain
  5. XM_005249961.5XP_005250018.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_005250018.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218238
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_005249960.5XP_005250017.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_005250017.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218238
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_005249959.5XP_005250016.1  zinc finger protein 467 isoform X4

    See identical proteins and their annotated locations for XP_005250016.1

    UniProtKB/Swiss-Prot
    Q7Z7K2
    Conserved Domains (2) summary
    COG5048
    Location:190565
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:218238
    ZF_C2H2; C2H2 Zn finger [structural motif]
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