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IFNLR1 interferon lambda receptor 1 [ Homo sapiens (human) ]

Gene ID: 163702, updated on 8-Jul-2021

Summary

Official Symbol
IFNLR1provided by HGNC
Official Full Name
interferon lambda receptor 1provided by HGNC
Primary source
HGNC:HGNC:18584
See related
Ensembl:ENSG00000185436 MIM:607404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1
Summary
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 5.6), lymph node (RPKM 4.0) and 22 other tissues See more
Orthologs
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Genomic context

See IFNLR1 in Genome Data Viewer
Location:
1p36.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (24154156..24187295, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24480658..24513779, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myomesin 3 Neighboring gene uncharacterized LOC105376864 Neighboring gene interleukin 22 receptor subunit alpha 1 Neighboring gene long intergenic non-protein coding RNA 2800 Neighboring gene GRHL3 antisense RNA 1 Neighboring gene grainyhead like transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytokine receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mucosal immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to type III interferon ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of interleukin-28 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interferon lambda receptor 1
Names
CRF2-12
IFN-lambda receptor 1
IFN-lambda-R1
IL-28 receptor subunit alpha
IL-28R-alpha
IL-28RA
class II cytokine receptor CRF2/12
cytokine receptor class-II member 12
cytokine receptor family 2 member 12
interleukin 28 alpha receptor
interleukin 28 receptor A
interleukin 28 receptor, alpha (interferon, lambda receptor)
interleukin or cytokine receptor 2
interleukin-28 receptor subunit alpha
likely interleukin or cytokine receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_170743.4NP_734464.1  interferon lambda receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_734464.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AF439325, AL590683, BC140872
    Consensus CDS
    CCDS248.1
    UniProtKB/Swiss-Prot
    Q8IU57
    Related
    ENSP00000327824.1, ENST00000327535.6
    Conserved Domains (1) summary
    pfam01108
    Location:19111
    Tissue_fac; Tissue factor
  2. NM_173064.3NP_775087.1  interferon lambda receptor 1 isoform 2

    See identical proteins and their annotated locations for NP_775087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame 3' coding segment, compared to variant 1. The resulting isoform (2) has a shorter C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AF439325, AL590683, AY129152, CN289861
    Consensus CDS
    CCDS249.1
    UniProtKB/Swiss-Prot
    Q8IU57
    Related
    ENSP00000363542.3, ENST00000374421.7
    Conserved Domains (1) summary
    pfam01108
    Location:19111
    Tissue_fac; Tissue factor
  3. NM_173065.3NP_775088.1  interferon lambda receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_775088.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one alternate segment and contains another in the 3' coding region which leads to a translation frameshift, as compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF439325, AJ534331, AL590683, CN289861
    Consensus CDS
    CCDS250.1
    UniProtKB/Swiss-Prot
    Q8IU57
    Related
    ENSP00000328994.2, ENST00000327575.6
    Conserved Domains (1) summary
    pfam01108
    Location:19111
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    24154156..24187295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453668.1XP_024309436.1  interferon lambda receptor 1 isoform X3

  2. XM_017000479.1XP_016855968.1  interferon lambda receptor 1 isoform X2

  3. XM_006710394.4XP_006710457.2  interferon lambda receptor 1 isoform X1

    Conserved Domains (1) summary
    cl21522
    Location:2980
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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