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ZNF114 zinc finger protein 114 [ Homo sapiens (human) ]

Gene ID: 163071, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF114provided by HGNC
Official Full Name
zinc finger protein 114provided by HGNC
Primary source
HGNC:HGNC:12894
See related
Ensembl:ENSG00000178150 MIM:603996; AllianceGenome:HGNC:12894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thyroid (RPKM 2.1), placenta (RPKM 0.5) and 12 other tissues See more
Orthologs
all
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Genomic context

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See ZNF114 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48270081..48287608)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51264184..51281737)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48773338..48790865)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14874 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48763364-48763544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14875 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene CARD8 antisense RNA 1 Neighboring gene ZNF114 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48774579-48775085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48775086-48775591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48794631-48795279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48798559-48799060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48799061-48799560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48800397-48800914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48806581-48807105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48807106-48807629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48811608-48812298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48812299-48812988 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene Sharpr-MPRA regulatory region 8297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10875 Neighboring gene uncharacterized LOC124904735 Neighboring gene Sharpr-MPRA regulatory region 73 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14881 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48827824-48828055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14885 Neighboring gene epithelial membrane protein 3 (MAM blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells. Chen Y, et al. Biochem Biophys Res Commun, 2022 Oct 15. PMID 35944360

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC17986, MGC149700

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 114
Names
zinc finger protein 114 (Y18)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331097.1 → NP_001318026.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392, AK291575
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Related
    ENSP00000471727.1, ENST00000600687.5
    Conserved Domains (5) summary
    sd00017
    Location:306 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:319 → 343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342 → 399
    Ribosomal_L37ae; Ribosomal L37ae protein family

  2. NM_001331098.1 → NP_001318027.1  zinc finger protein 114 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longer isoform (3).
    Source sequence(s)
    AC008392
    Conserved Domains (6) summary
    smart00349
    Location:52 → 111
    KRAB; krueppel associated box
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434 → 456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:52 → 91
    KRAB; KRAB box
    pfam13465
    Location:365 → 389
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:388 → 445
    Ribosomal_L37ae; Ribosomal L37ae protein family

  3. NM_001369811.1 → NP_001356740.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Related
    ENSP00000318898.1, ENST00000315849.5
    Conserved Domains (5) summary
    sd00017
    Location:306 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:319 → 343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342 → 399
    Ribosomal_L37ae; Ribosomal L37ae protein family

  4. NM_001369812.1 → NP_001356741.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3, and 5, encodes isoform 1.
    Source sequence(s)
    AC008392
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Conserved Domains (5) summary
    sd00017
    Location:306 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:319 → 343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342 → 399
    Ribosomal_L37ae; Ribosomal L37ae protein family

  5. NM_153608.4 → NP_705836.1  zinc finger protein 114 isoform 1

    See identical proteins and their annotated locations for NP_705836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 3, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392, AK075062, BG476217
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Related
    ENSP00000469998.1, ENST00000595607.6
    Conserved Domains (5) summary
    sd00017
    Location:306 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5 → 46
    KRAB; KRAB box
    pfam13465
    Location:319 → 343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342 → 399
    Ribosomal_L37ae; Ribosomal L37ae protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48270081..48287608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026414.3 → XP_016881903.1  zinc finger protein 114 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:52 → 111
    KRAB; krueppel associated box
    sd00017
    Location:352 → 372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434 → 456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:52 → 91
    KRAB; KRAB box
    pfam13465
    Location:365 → 389
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:388 → 445
    Ribosomal_L37ae; Ribosomal L37ae protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51264184..51281737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320065.1 → XP_054176040.1  zinc finger protein 114 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001301062.1: Suppressed sequence

    Description
    NM_001301062.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NC26.1 GenPept UniProtKB/Swiss-Prot:Q8NC26

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