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ZNF114 zinc finger protein 114 [ Homo sapiens (human) ]

Gene ID: 163071, updated on 23-Nov-2021

Summary

Official Symbol
ZNF114provided by HGNC
Official Full Name
zinc finger protein 114provided by HGNC
Primary source
HGNC:HGNC:12894
See related
Ensembl:ENSG00000178150 MIM:603996
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in thyroid (RPKM 2.1), placenta (RPKM 0.5) and 12 other tissues See more
Orthologs
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Genomic context

See ZNF114 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48270081..48287608)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48773338..48790865)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 8 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene CARD8 antisense RNA 1 Neighboring gene ZNF114 antisense RNA 1 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene Sharpr-MPRA regulatory region 8297 Neighboring gene Sharpr-MPRA regulatory region 73

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17986, MGC149700

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 114
Names
zinc finger protein 114 (Y18)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331097.1NP_001318026.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392, AK291575
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    Q8NC26
    Related
    ENSP00000471727.1, ENST00000600687.5
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family
  2. NM_001331098.1NP_001318027.1  zinc finger protein 114 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longer isoform (3).
    Source sequence(s)
    AC008392
    Conserved Domains (6) summary
    smart00349
    Location:52111
    KRAB; krueppel associated box
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5291
    KRAB; KRAB box
    pfam13465
    Location:365389
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:388445
    Ribosomal_L37ae; Ribosomal L37ae protein family
  3. NM_001369811.1NP_001356740.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392
    Related
    ENSP00000318898.1, ENST00000315849.5
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family
  4. NM_001369812.1NP_001356741.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3, and 5, encodes isoform 1.
    Source sequence(s)
    AC008392
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family
  5. NM_153608.4NP_705836.1  zinc finger protein 114 isoform 1

    See identical proteins and their annotated locations for NP_705836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 3, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392, AK075062, BG476217
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    Q8NC26
    Related
    ENSP00000469998.1, ENST00000595607.6
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    48270081..48287608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026414.2XP_016881903.1  zinc finger protein 114 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:52111
    KRAB; krueppel associated box
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5291
    KRAB; KRAB box
    pfam13465
    Location:365389
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:388445
    Ribosomal_L37ae; Ribosomal L37ae protein family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001301062.1: Suppressed sequence

    Description
    NM_001301062.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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