U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF114 zinc finger protein 114 [ Homo sapiens (human) ]

Gene ID: 163071, updated on 23-Nov-2023

Summary

Official Symbol
ZNF114provided by HGNC
Official Full Name
zinc finger protein 114provided by HGNC
Primary source
HGNC:HGNC:12894
See related
Ensembl:ENSG00000178150 MIM:603996; AllianceGenome:HGNC:12894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 2.1), placenta (RPKM 0.5) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF114 in Genome Data Viewer
Location:
19q13.33
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48270081..48287608)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51264184..51281737)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48773338..48790865)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14874 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48763364-48763544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14875 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene CARD8 antisense RNA 1 Neighboring gene ZNF114 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48774579-48775085 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48775086-48775591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48794631-48795279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48798559-48799060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48799061-48799560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48800397-48800914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48806581-48807105 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48807106-48807629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48811608-48812298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48812299-48812988 Neighboring gene outer dynein arm docking complex subunit 1 Neighboring gene Sharpr-MPRA regulatory region 8297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10875 Neighboring gene uncharacterized LOC124904735 Neighboring gene Sharpr-MPRA regulatory region 73 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14881 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:48827824-48828055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14885 Neighboring gene epithelial membrane protein 3 (MAM blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC17986, MGC149700

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 114
Names
zinc finger protein 114 (Y18)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331097.1NP_001318026.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392, AK291575
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Related
    ENSP00000471727.1, ENST00000600687.5
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family
  2. NM_001331098.1NP_001318027.1  zinc finger protein 114 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longer isoform (3).
    Source sequence(s)
    AC008392
    Conserved Domains (6) summary
    smart00349
    Location:52111
    KRAB; krueppel associated box
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5291
    KRAB; KRAB box
    pfam13465
    Location:365389
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:388445
    Ribosomal_L37ae; Ribosomal L37ae protein family
  3. NM_001369811.1NP_001356740.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 3, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Related
    ENSP00000318898.1, ENST00000315849.5
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family
  4. NM_001369812.1NP_001356741.1  zinc finger protein 114 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3, and 5, encodes isoform 1.
    Source sequence(s)
    AC008392
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family
  5. NM_153608.4NP_705836.1  zinc finger protein 114 isoform 1

    See identical proteins and their annotated locations for NP_705836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 3, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AC008392, AK075062, BG476217
    Consensus CDS
    CCDS12713.1
    UniProtKB/Swiss-Prot
    A8K6B0, Q08AQ6, Q8NC26
    Related
    ENSP00000469998.1, ENST00000595607.6
    Conserved Domains (5) summary
    sd00017
    Location:306326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304326
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:342399
    Ribosomal_L37ae; Ribosomal L37ae protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48270081..48287608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026414.3XP_016881903.1  zinc finger protein 114 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:52111
    KRAB; krueppel associated box
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5291
    KRAB; KRAB box
    pfam13465
    Location:365389
    zf-H2C2_2; Zinc-finger double domain
    cl19284
    Location:388445
    Ribosomal_L37ae; Ribosomal L37ae protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51264184..51281737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320065.1XP_054176040.1  zinc finger protein 114 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001301062.1: Suppressed sequence

    Description
    NM_001301062.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.